NHP2L1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''NHP2-like protein 1''' is a [[protein]] that in humans is encoded by the ''NHP2L1'' [[gene]].<ref name="pmid8978773">{{cite journal | vauthors = Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y | title = Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2 | journal = Cytogenetics and Cell Genetics | volume = 72 | issue = 2-3 | pages = 191–3 | date = Jan 1997 | pmid = 8978773 | pmc = | doi = 10.1159/000134186 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4809| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NHP2L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e7k.
| PDB = {{PDB2|1e7k}}, {{PDB2|2ozb}}
| Name = NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
| HGNCid = 7819
| Symbol = NHP2L1
| AltSymbols =; NHPX; OTK27; SNU13
| OMIM = 601304
| ECnumber = 
| Homologene = 3672
| MGIid = 
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0042254 |text = ribosome biogenesis and assembly}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4809
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001003796
    | Hs_RefseqmRNA = NM_001003796
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)''', also known as '''NHP2L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4809| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4809| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NHP2L1 has been shown to [[Protein-protein interaction|interact]] with [[RAD17]].<ref name=pmid10593953>{{cite journal | vauthors = Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB | title = HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36544–9 | date = Dec 1999 | pmid = 10593953 | doi = 10.1074/jbc.274.51.36544 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nottrott S, Hartmuth K, Fabrizio P, Urlaub H, Vidovic I, Ficner R, Lührmann R | title = Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA | journal = The EMBO Journal | volume = 18 | issue = 21 | pages = 6119–33 | date = Nov 1999 | pmid = 10545122 | pmc = 1171676 | doi = 10.1093/emboj/18.21.6119 }}
| citations =
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Saito H, Fujiwara T, Shin S, ''et al.'' |title=Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 191-3 |year= 1997 |pmid= 8978773 |doi=  }}
* {{cite journal | vauthors = Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB | title = HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36544–9 | date = Dec 1999 | pmid = 10593953 | doi = 10.1074/jbc.274.51.36544 }}
*{{cite journal  | author=Nottrott S, Hartmuth K, Fabrizio P, ''et al.'' |title=Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. |journal=EMBO J. |volume=18 |issue= 21 |pages= 6119-33 |year= 2000 |pmid= 10545122 |doi= 10.1093/emboj/18.21.6119 }}
* {{cite journal | vauthors = Vidovic I, Nottrott S, Hartmuth K, Lührmann R, Ficner R | title = Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment | journal = Molecular Cell | volume = 6 | issue = 6 | pages = 1331–42 | date = Dec 2000 | pmid = 11163207 | doi = 10.1016/S1097-2765(00)00131-3 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Chang MS, Sasaki H, Campbell MS, ''et al.'' |title=HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36544-9 |year= 2000 |pmid= 10593953 |doi= }}
* {{cite journal | vauthors = Leung AK, Lamond AI | title = In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles | journal = The Journal of Cell Biology | volume = 157 | issue = 4 | pages = 615–29 | date = May 2002 | pmid = 12011111 | pmc = 2173864 | doi = 10.1083/jcb.200201120 }}
*{{cite journal | author=Vidovic I, Nottrott S, Hartmuth K, ''et al.'' |title=Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1331-42 |year= 2001 |pmid= 11163207 |doi= }}
* {{cite journal | vauthors = Watkins NJ, Dickmanns A, Lührmann R | title = Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP | journal = Molecular and Cellular Biology | volume = 22 | issue = 23 | pages = 8342–52 | date = Dec 2002 | pmid = 12417735 | pmc = 134055 | doi = 10.1128/MCB.22.23.8342-8352.2002 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = Nov 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Leung AK, Lamond AI |title=In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles. |journal=J. Cell Biol. |volume=157 |issue= 4 |pages= 615-29 |year= 2002 |pmid= 12011111 |doi= 10.1083/jcb.200201120 }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biology | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Watkins NJ, Dickmanns A, Lührmann R |title=Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8342-52 |year= 2003 |pmid= 12417735 |doi= }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4809}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:58, 5 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NHP2-like protein 1 is a protein that in humans is encoded by the NHP2L1 gene.[1][2]

Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.[2]

Interactions

NHP2L1 has been shown to interact with RAD17.[3]

References

  1. ↑ Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y (Jan 1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2". Cytogenetics and Cell Genetics. 72 (2–3): 191–3. doi:10.1159/000134186. PMID 8978773.
  2. ↑ 2.0 2.1 "Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)".
  3. ↑ Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". The Journal of Biological Chemistry. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.

Further reading

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