UPK3A: Difference between revisions

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{{Infobox_gene}}
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'''Uroplakin-3a''' is a [[protein]] that in humans is encoded by the ''UPK3A'' [[gene]].<ref name="pmid9818021">{{cite journal | vauthors = Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y | title = Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma | journal = Jpn J Cancer Res | volume = 89 | issue = 9 | pages = 879–82 |date=Dec 1998 | pmid = 9818021 | pmc =  | doi =  10.1111/j.1349-7006.1998.tb00643.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPK3A uroplakin 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7380| accessdate = }}</ref> It is found in the inner membrane of the urinary bladder and contributes to the strength and that membrane and to the membrane's ability to stretch when the bladder is full.<ref>{{cite journal | pmc = 3717210 | pmid=19340092 | doi=10.1038/ki.2009.73 | volume=75 | title=Uroplakins in urothelial biology, function, and disease | year=2009 | journal=Kidney Int. | pages=1153–65 | vauthors=Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT}}</ref>  It is also found in the renal pelvis, ureter, and prostatic urethra.
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Uroplakin 3A
| HGNCid = 12580
| Symbol = UPK3A
| AltSymbols =; MGC119178; UPIII; UPK3
| OMIM =
| ECnumber =
  | Homologene = 5066
  | MGIid = 98914
| GeneAtlas_image1 = PBB_GE_UPK3A_206771_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7380
    | Hs_Ensembl = ENSG00000100373
    | Hs_RefseqProtein = NP_008884
    | Hs_RefseqmRNA = NM_006953
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 44059527
    | Hs_GenLoc_end = 44070418
    | Hs_Uniprot = O75631
    | Mm_EntrezGene = 22270
    | Mm_Ensembl = ENSMUSG00000022435
    | Mm_RefseqmRNA = NM_023478
    | Mm_RefseqProtein = NP_075967
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 84844986
    | Mm_GenLoc_end = 84850300
    | Mm_Uniprot = Q27QV3
  }}
}}
'''Uroplakin 3A''', also known as '''UPK3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK3A uroplakin 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7380| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wu XR, Sun TT |title=Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. |journal=J. Cell. Sci. |volume=106 ( Pt 1) |issue=  |pages= 31-43 |year= 1994 |pmid= 8270634 |doi=  }}
*{{cite journal  | vauthors=Wu XR, Sun TT |title=Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. |journal=J. Cell Sci. |volume=106 |issue=  1|pages= 31–43 |year= 1994 |pmid= 8270634 |doi=  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Yuasa T, Yoshiki T, Tanaka T, ''et al.'' |title=Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. |journal=Jpn. J. Cancer Res. |volume=89 |issue= 9 |pages= 879-82 |year= 1998 |pmid= 9818021 |doi= }}
*{{cite journal   |vauthors=Lobban ED, Smith BA, Hall GD, etal |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957–67 |year= 1998 |pmid= 9846985 |doi= 10.1016/S0002-9440(10)65709-4| pmc=1866332 }}
*{{cite journal | author=Lobban ED, Smith BA, Hall GD, ''et al.'' |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957-67 |year= 1998 |pmid= 9846985 |doi=  }}
*{{cite journal  | vauthors=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi= 10.1016/S0002-9440(10)65206-6| pmc=1867018 }}
*{{cite journal  | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047-50 |year= 1999 |pmid= 10514386 |doi=  }}
*{{cite journal   |vauthors=Olsburgh J, Harnden P, Weeks R, etal |title=Uroplakin gene expression in normal human tissues and locally advanced bladder cancer |journal=J. Pathol. |volume=199 |issue= 1 |pages= 41–9 |year= 2003 |pmid= 12474225 |doi= 10.1002/path.1252 }}
*{{cite journal | author=Olsburgh J, Harnden P, Weeks R, ''et al.'' |title=Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. |journal=J. Pathol. |volume=199 |issue= 1 |pages= 41-9 |year= 2003 |pmid= 12474225 |doi= 10.1002/path.1252 }}
*{{cite journal  | vauthors=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 | pmc=138628 }}
*{{cite journal  | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221-30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Koga F, Kawakami S, Fujii Y, etal |title=Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5501–7 |year= 2004 |pmid= 14654529 |doi=  }}
*{{cite journal | author=Koga F, Kawakami S, Fujii Y, ''et al.'' |title=Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5501-7 |year= 2004 |pmid= 14654529 |doi=  }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Schönfelder EM, Knüppel T, Tasic V, etal |title=Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans |journal=Am. J. Kidney Dis. |volume=47 |issue= 6 |pages= 1004–12 |year= 2006 |pmid= 16731295 |doi= 10.1053/j.ajkd.2006.02.177 }}
*{{cite journal | author=Schönfelder EM, Knüppel T, Tasic V, ''et al.'' |title=Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans. |journal=Am. J. Kidney Dis. |volume=47 |issue= 6 |pages= 1004-12 |year= 2006 |pmid= 16731295 |doi= 10.1053/j.ajkd.2006.02.177 }}
*{{cite journal   |vauthors=Zeng Y, Wu XX, Homma Y, etal |title=Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis |journal=J. Urol. |volume=178 |issue= 4 Pt 1 |pages= 1322–7; discussion 1327 |year= 2007 |pmid= 17698128 |doi= 10.1016/j.juro.2007.05.125 }}
*{{cite journal | author=Zeng Y, Wu XX, Homma Y, ''et al.'' |title=Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis. |journal=J. Urol. |volume=178 |issue= 4 Pt 1 |pages= 1322-7; discussion 1327 |year= 2007 |pmid= 17698128 |doi= 10.1016/j.juro.2007.05.125 }}
}}
}}
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[[Category:Uroplakins]]


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Revision as of 22:35, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Uroplakin-3a is a protein that in humans is encoded by the UPK3A gene.[1][2] It is found in the inner membrane of the urinary bladder and contributes to the strength and that membrane and to the membrane's ability to stretch when the bladder is full.[3] It is also found in the renal pelvis, ureter, and prostatic urethra.


References

  1. ↑ Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y (Dec 1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn J Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMID 9818021.
  2. ↑ "Entrez Gene: UPK3A uroplakin 3A".
  3. ↑ Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009). "Uroplakins in urothelial biology, function, and disease". Kidney Int. 75: 1153–65. doi:10.1038/ki.2009.73. PMC 3717210. PMID 19340092.

Further reading


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