SEPT5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Septin-5''' is a [[protein]] that in humans is encoded by the ''SEPT5'' [[gene]].<ref name="pmid9385360">{{cite journal | vauthors = McKie JM, Sutherland HF, Harvey E, Kim UJ, Scambler PJ | title = A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11 | journal = Human Genetics | volume = 101 | issue = 1 | pages = 6–12 | date = November 1997 | pmid = 9385360 | pmc =  | doi = 10.1007/s004390050576 }}</ref><ref name="pmid9611266">{{cite journal | vauthors = Yagi M, Zieger B, Roth GJ, Ware J | title = Structure and expression of the human septin gene HCDCREL-1 | journal = Gene | volume = 212 | issue = 2 | pages = 229–36 | date = June 1998 | pmid = 9611266 | pmc =  | doi = 10.1016/S0378-1119(98)00146-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEPT5 septin 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5413| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Septin 5
| HGNCid = 9164
| Symbol = SEPT5
| AltSymbols =; CDCREL; CDCREL-1; CDCREL1; H5; PNUTL1
| OMIM = 602724
| ECnumber = 
| Homologene = 74446
| MGIid = 1195461
| GeneAtlas_image1 = PBB_GE_SEPT5_209767_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SEPT5_209768_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}}
| Process = {{GNF_GO|id=GO:0000910 |text = cytokinesis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0016080 |text = synaptic vesicle targeting}} {{GNF_GO|id=GO:0017157 |text = regulation of exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5413
    | Hs_Ensembl = ENSG00000184702
    | Hs_RefseqProtein = NP_002679
    | Hs_RefseqmRNA = NM_002688
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 18082112
    | Hs_GenLoc_end = 18090007
    | Hs_Uniprot = Q99719
    | Mm_EntrezGene = 18951
    | Mm_Ensembl = ENSMUSG00000072214
    | Mm_RefseqmRNA = NM_213614
    | Mm_RefseqProtein = NP_998779
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 18535374
    | Mm_GenLoc_end = 18543501
    | Mm_Uniprot = Q68FM0
  }}
}}
'''Septin 5''', also known as '''SEPT5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEPT5 septin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5413| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[septin]] gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in [[yeast]], [[Drosophila]], and [[mouse]] and appear to regulate [[Cytoskeleton|cytoskeletal]] organization. Disruption of septin function disturbs [[cytokinesis]] and results in large [[multinucleate]] or [[Polyploidy|polyploid]] cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.<ref name="entrez">{{cite web | title = Entrez Gene: SEPT5 septin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5413| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SEPT5 has been shown to [[Protein-protein interaction|interact]] with:
* [[Parkin (ligase)|PARK2]],<ref name = pmid14559152>{{cite journal | vauthors = Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B | author15-link=Benjamin Wolozin | title = SEPT5_v2 is a parkin-binding protein | journal = Brain Research. Molecular Brain Research | volume = 117 | issue = 2 | pages = 179–89 | date = October 2003 | pmid = 14559152 | doi = 10.1016/S0169-328X(03)00318-8 }}</ref><ref name = pmid18845538>{{cite journal | vauthors = Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J | title = Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 51 | pages = 35783–8 | date = December 2008 | pmid = 18845538 | doi = 10.1074/jbc.M806860200 }}</ref> and
* [[SEPT8]]<ref name = pmid12909369>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}</ref><ref name = pmid12023038>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yagi M, Edelhoff S, Disteche CM, Roth GJ | title = Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta | journal = The Journal of Biological Chemistry | volume = 269 | issue = 26 | pages = 17424–7 | date = July 1994 | pmid = 8021244 | doi =  }}
| citations =
* {{cite journal | vauthors = Zieger B, Hashimoto Y, Ware J | title = Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence | journal = The Journal of Clinical Investigation | volume = 99 | issue = 3 | pages = 520–5 | date = February 1997 | pmid = 9022087 | pmc = 507827 | doi = 10.1172/JCI119188 }}
*{{cite journal | author=Yagi M, Edelhoff S, Disteche CM, Roth GJ |title=Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta. |journal=J. Biol. Chem. |volume=269 |issue= 26 |pages= 17424-7 |year= 1994 |pmid= 8021244 |doi=  }}
* {{cite journal | vauthors = Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA | title = t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 11 | pages = 6413–8 | date = May 1998 | pmid = 9600980 | pmc = 27754 | doi = 10.1073/pnas.95.11.6413 }}
*{{cite journal | author=Zieger B, Hashimoto Y, Ware J |title=Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence. |journal=J. Clin. Invest. |volume=99 |issue= 3 |pages= 520-5 |year= 1997 |pmid= 9022087 |doi= }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | date = June 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
*{{cite journal  | author=McKie JM, Sutherland HF, Harvey E, ''et al.'' |title=A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. |journal=Hum. Genet. |volume=101 |issue= 1 |pages= 6-12 |year= 1997 |pmid= 9385360 |doi=  }}
* {{cite journal | vauthors = Caltagarone J, Rhodes J, Honer WG, Bowser R | title = Localization of a novel septin protein, hCDCrel-1, in neurons of human brain | journal = Neuroreport | volume = 9 | issue = 12 | pages = 2907–12 | date = August 1998 | pmid = 9760144 | doi = 10.1097/00001756-199808240-00042 }}
*{{cite journal | author=Megonigal MD, Rappaport EF, Jones DH, ''et al.'' |title=t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6413-8 |year= 1998 |pmid= 9600980 |doi= }}
* {{cite journal | vauthors = Beites CL, Xie H, Bowser R, Trimble WS | title = The septin CDCrel-1 binds syntaxin and inhibits exocytosis | journal = Nature Neuroscience | volume = 2 | issue = 5 | pages = 434–9 | date = May 1999 | pmid = 10321247 | doi = 10.1038/8100 }}
*{{cite journal  | author=Yagi M, Zieger B, Roth GJ, Ware J |title=Structure and expression of the human septin gene HCDCREL-1. |journal=Gene |volume=212 |issue= 2 |pages= 229-36 |year= 1998 |pmid= 9611266 |doi=  }}
* {{cite journal | vauthors = Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM | title = Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 24 | pages = 13354–9 | date = November 2000 | pmid = 11078524 | pmc = 27228 | doi = 10.1073/pnas.240347797 }}
*{{cite journal | author=Hsu SC, Hazuka CD, Roth R, ''et al.'' |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111-22 |year= 1998 |pmid= 9655500 |doi= }}
* {{cite journal | vauthors = Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB | title = A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif | journal = Nature Cell Biology | volume = 2 | issue = 12 | pages = 915–21 | date = December 2000 | pmid = 11146656 | doi = 10.1038/35046566 }}
*{{cite journal | author=Caltagarone J, Rhodes J, Honer WG, Bowser R |title=Localization of a novel septin protein, hCDCrel-1, in neurons of human brain. |journal=Neuroreport |volume=9 |issue= 12 |pages= 2907-12 |year= 1998 |pmid= 9760144 |doi= }}
* {{cite journal | vauthors = Dent J, Kato K, Peng XR, Martinez C, Cattaneo M, Poujol C, Nurden P, Nurden A, Trimble WS, Ware J | title = A prototypic platelet septin and its participation in secretion | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 5 | pages = 3064–9 | date = March 2002 | pmid = 11880646 | pmc = 122473 | doi = 10.1073/pnas.052715199 }}
*{{cite journal | author=Beites CL, Xie H, Bowser R, Trimble WS |title=The septin CDCrel-1 binds syntaxin and inhibits exocytosis. |journal=Nat. Neurosci. |volume=2 |issue= 5 |pages= 434-9 |year= 1999 |pmid= 10321247 |doi= 10.1038/8100 }}
* {{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}
*{{cite journal | author=Zhang Y, Gao J, Chung KK, ''et al.'' |title=Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13354-9 |year= 2001 |pmid= 11078524 |doi= 10.1073/pnas.240347797 }}
* {{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}
*{{cite journal | author=Larisch S, Yi Y, Lotan R, ''et al.'' |title=A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 915-21 |year= 2001 |pmid= 11146656 |doi= 10.1038/35046566 }}
* {{cite journal | vauthors = Dong Z, Ferger B, Paterna JC, Vogel D, Furler S, Osinde M, Feldon J, Büeler H | title = Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12438–43 | date = October 2003 | pmid = 14530399 | pmc = 218776 | doi = 10.1073/pnas.2132992100 }}
*{{cite journal | author=Dent J, Kato K, Peng XR, ''et al.'' |title=A prototypic platelet septin and its participation in secretion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 3064-9 |year= 2002 |pmid= 11880646 |doi= 10.1073/pnas.052715199 }}
* {{cite journal | vauthors = Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B | title = SEPT5_v2 is a parkin-binding protein | journal = Brain Research. Molecular Brain Research | volume = 117 | issue = 2 | pages = 179–89 | date = October 2003 | pmid = 14559152 | doi = 10.1016/S0169-328X(03)00318-8 }}
*{{cite journal | author=Bläser S, Jersch K, Hainmann I, ''et al.'' |title=Human septin-septin interaction: CDCrel-1 partners with KIAA0202. |journal=FEBS Lett. |volume=519 |issue= 1-3 |pages= 169-72 |year= 2002 |pmid= 12023038 |doi= }}
* {{cite journal | vauthors = Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B | title = The novel human platelet septin SEPT8 is an interaction partner of SEPT4 | journal = Thrombosis and Haemostasis | volume = 91 | issue = 5 | pages = 959–66 | date = May 2004 | pmid = 15116257 | doi = 10.1160/TH03-09-0578 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J | title = Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol | journal = The Biochemical Journal | volume = 382 | issue = Pt 3 | pages = 783–91 | date = September 2004 | pmid = 15214843 | pmc = 1133953 | doi = 10.1042/BJ20040372 }}
*{{cite journal | author=Bläser S, Jersch K, Hainmann I, ''et al.'' |title=Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202). |journal=Gene |volume=312 |issue=  |pages= 313-20 |year= 2003 |pmid= 12909369 |doi= }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal | author=Dong Z, Ferger B, Paterna JC, ''et al.'' |title=Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12438-43 |year= 2003 |pmid= 14530399 |doi= 10.1073/pnas.2132992100 }}
*{{cite journal | author=Choi P, Snyder H, Petrucelli L, ''et al.'' |title=SEPT5_v2 is a parkin-binding protein. |journal=Brain Res. Mol. Brain Res. |volume=117 |issue= 2 |pages= 179-89 |year= 2004 |pmid= 14559152 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Bläser S, Horn J, Würmell P, ''et al.'' |title=The novel human platelet septin SEPT8 is an interaction partner of SEPT4. |journal=Thromb. Haemost. |volume=91 |issue= 5 |pages= 959-66 |year= 2004 |pmid= 15116257 |doi= 10.1267/THRO04050959 }}
*{{cite journal | author=Martínez C, Sanjuan MA, Dent JA, ''et al.'' |title=Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. |journal=Biochem. J. |volume=382 |issue= Pt 3 |pages= 783-91 |year= 2005 |pmid= 15214843 |doi= 10.1042/BJ20040372 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
}}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{gene-22-stub}}
{{WikiDoc Sources}}

Revision as of 06:07, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Septin-5 is a protein that in humans is encoded by the SEPT5 gene.[1][2][3]

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.[3]

Interactions

SEPT5 has been shown to interact with:

References

  1. ↑ McKie JM, Sutherland HF, Harvey E, Kim UJ, Scambler PJ (November 1997). "A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11". Human Genetics. 101 (1): 6–12. doi:10.1007/s004390050576. PMID 9385360.
  2. ↑ Yagi M, Zieger B, Roth GJ, Ware J (June 1998). "Structure and expression of the human septin gene HCDCREL-1". Gene. 212 (2): 229–36. doi:10.1016/S0378-1119(98)00146-2. PMID 9611266.
  3. ↑ 3.0 3.1 "Entrez Gene: SEPT5 septin 5".
  4. ↑ Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B (October 2003). "SEPT5_v2 is a parkin-binding protein". Brain Research. Molecular Brain Research. 117 (2): 179–89. doi:10.1016/S0169-328X(03)00318-8. PMID 14559152.
  5. ↑ Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J (December 2008). "Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase". The Journal of Biological Chemistry. 283 (51): 35783–8. doi:10.1074/jbc.M806860200. PMID 18845538.
  6. ↑ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
  7. ↑ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SEPT5&oldid=1419999"