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{{Underlinked|date=October 2016}}
{{Infobox_gene}}
'''Basic salivary proline-rich protein 4''' is a [[protein]] that in humans is encoded by the ''PRB4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5545| accessdate = }}</ref>
The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.<ref name="entrez" />
PRB4 is post-translationally cleaved into three different mature peptides:
*Protein N1
*Glycosylated protein A
*Peptide P-D (also known as proline-rich peptide IB-5)
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Azen EA, Maeda N |title=Molecular genetics of human salivary proteins and their polymorphisms |journal=Adv. Hum. Genet. |volume=17 |issue=  |pages= 141–99 |year= 1988 |pmid= 3055850 |doi=  10.1007/978-1-4613-0987-1_5}}
*{{cite journal  | author=Bennick A |title=Salivary proline-rich proteins |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83–99 |year= 1982 |pmid= 6810092 |doi=10.1007/BF00223503  }}
*{{cite journal  | vauthors=Lyons KM, Stein JH, Smithies O |title=Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over |journal=Genetics |volume=120 |issue= 1 |pages= 267–78 |year= 1989 |pmid= 2851479 |doi=  | pmc=1203497  }}
*{{cite journal  | vauthors=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123–30 |year= 1985 |pmid= 2993301 |doi=  }}
*{{cite journal  | vauthors=Lyons KM, Azen EA, Goodman PA, Smithies O |title=Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci |journal=Genetics |volume=120 |issue= 1 |pages= 255–65 |year= 1989 |pmid= 3220251 |doi=  | pmc=1203496  }}
*{{cite journal  | vauthors=Warner TF, Azen EA |title=Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract |journal=Am. Rev. Respir. Dis. |volume=130 |issue= 1 |pages= 115–8 |year= 1984 |pmid= 6377992 |doi=  }}
*{{cite journal  | vauthors=Saitoh E, Isemura S, Sanada K |title=Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva |journal=J. Biochem. |volume=93 |issue= 2 |pages= 495–502 |year= 1983 |pmid= 6841349 |doi=10.1093/jb/93.3.883  }}
*{{cite journal  | vauthors=Kauffman DL, Keller PJ, Bennick A, Blum M |title=Alignment of amino acid and DNA sequences of human proline-rich proteins |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3–4 |pages= 287–92 |year= 1993 |pmid= 8373986 |doi=  }}
*{{cite journal  |vauthors=Kim HS, Lyons KM, Saitoh E, etal |title=The structure and evolution of the human salivary proline-rich protein gene family |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3–14 |year= 1993 |pmid= 8422499 |doi=10.1007/BF00364656  }}
*{{cite journal  |vauthors=Azen EA, Amberger E, Fisher S, etal |title=PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins |journal=Am. J. Hum. Genet. |volume=58 |issue= 1 |pages= 143–53 |year= 1996 |pmid= 8554050 |doi=  | pmc=1914931  }}
*{{cite journal  | vauthors=Castle AM, Castle JD |title=Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575–83 |year= 1998 |pmid= 9487127 |doi=  10.1091/mbc.9.3.575| pmc=25286  }}
*{{cite journal  | vauthors=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423–31 |year= 2001 |pmid= 11422372 |doi=10.1046/j.1432-1327.2001.02241.x  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Vallat JM, Magy L, Lagrange E, etal |title=Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance |journal=Acta Neuropathol. |volume=113 |issue= 4 |pages= 443–9 |year= 2007 |pmid= 17294201 |doi= 10.1007/s00401-007-0196-7 }}
}}
{{refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Category:Precursor proteins]]
{{GNF_Protein_box
[[Category:Salivary proline-rich proteins]]
| image = 
| image_source = 
| PDB =
| Name = Proline-rich protein BstNI subfamily 4
| HGNCid = 9340
| Symbol = PRB4
| AltSymbols =; Po
| OMIM = 180990
| ECnumber = 
| Homologene = 74447
| MGIid = 
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5545
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002714
    | Hs_RefseqmRNA = NM_002723
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Proline-rich protein BstNI subfamily 4''', also known as '''PRB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5545| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.<ref name="entrez">{{cite web | title = Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5545| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Azen EA, Maeda N |title=Molecular genetics of human salivary proteins and their polymorphisms. |journal=Adv. Hum. Genet. |volume=17 |issue=  |pages= 141-99 |year= 1988 |pmid= 3055850 |doi=  }}
*{{cite journal  | author=Bennick A |title=Salivary proline-rich proteins. |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83-99 |year= 1982 |pmid= 6810092 |doi=  }}
*{{cite journal  | author=Lyons KM, Stein JH, Smithies O |title=Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. |journal=Genetics |volume=120 |issue= 1 |pages= 267-78 |year= 1989 |pmid= 2851479 |doi=  }}
*{{cite journal  | author=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123-30 |year= 1985 |pmid= 2993301 |doi=  }}
*{{cite journal  | author=Lyons KM, Azen EA, Goodman PA, Smithies O |title=Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci. |journal=Genetics |volume=120 |issue= 1 |pages= 255-65 |year= 1989 |pmid= 3220251 |doi=  }}
*{{cite journal  | author=Warner TF, Azen EA |title=Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract. |journal=Am. Rev. Respir. Dis. |volume=130 |issue= 1 |pages= 115-8 |year= 1984 |pmid= 6377992 |doi=  }}
*{{cite journal  | author=Saitoh E, Isemura S, Sanada K |title=Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva. |journal=J. Biochem. |volume=93 |issue= 2 |pages= 495-502 |year= 1983 |pmid= 6841349 |doi=  }}
*{{cite journal  | author=Kauffman DL, Keller PJ, Bennick A, Blum M |title=Alignment of amino acid and DNA sequences of human proline-rich proteins. |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3-4 |pages= 287-92 |year= 1993 |pmid= 8373986 |doi=  }}
*{{cite journal  | author=Kim HS, Lyons KM, Saitoh E, ''et al.'' |title=The structure and evolution of the human salivary proline-rich protein gene family. |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3-14 |year= 1993 |pmid= 8422499 |doi=  }}
*{{cite journal  | author=Azen EA, Amberger E, Fisher S, ''et al.'' |title=PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. |journal=Am. J. Hum. Genet. |volume=58 |issue= 1 |pages= 143-53 |year= 1996 |pmid= 8554050 |doi=  }}
*{{cite journal  | author=Castle AM, Castle JD |title=Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein. |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575-83 |year= 1998 |pmid= 9487127 |doi=  }}
*{{cite journal  | author=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases. |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423-31 |year= 2001 |pmid= 11422372 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Vallat JM, Magy L, Lagrange E, ''et al.'' |title=Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance. |journal=Acta Neuropathol. |volume=113 |issue= 4 |pages= 443-9 |year= 2007 |pmid= 17294201 |doi= 10.1007/s00401-007-0196-7 }}
}}
{{refend}}


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{{protein-stub}}
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Revision as of 19:06, 16 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.[1]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.[1]

PRB4 is post-translationally cleaved into three different mature peptides:

  • Protein N1
  • Glycosylated protein A
  • Peptide P-D (also known as proline-rich peptide IB-5)

References

  1. ↑ 1.0 1.1 "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

Further reading


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