CENTG1: Difference between revisions

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Latest revision as of 19:33, 8 November 2017

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.^[1]

Interactions

CENTG1 has been shown to interact with:

References

↑ "Entrez Gene: CENTG1 centaurin, gamma 1".
↑ ^2.0 ^2.1 Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
↑ Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.

External links

Human AGAP2 genome location and AGAP2 gene details page in the UCSC Genome Browser.

Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature. 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862.
Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. doi:10.1073/pnas.0400921101. PMC 406454. PMID 15118108.
Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". J. Cell Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119.
Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930.
Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848. PMID 17037982.
Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107.
Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440.
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: CENTG1 centaurin, gamma 1".

[pmid11136977-2] 2.0 ^2.1 Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.

[pmid14528310-3] Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2''' is a [[protein]] that in humans is encoded by the ''AGAP2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENTG1 centaurin, gamma 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116986| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
+CENTG1 has been shown to [[Protein-protein interaction|interact]] with:
- | image = PBB_Protein_CENTG1_image.jpg
+* [[EPB41L1]],<ref name = pmid11136977/>
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bmj.
+* [[HOMER1]]<ref name = pmid14528310>{{cite journal | vauthors = Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K | title = PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis | journal = Nat. Neurosci. | volume = 6 | issue = 11 | pages = 1153–61 | date = November 2003 | pmid = 14528310 | doi = 10.1038/nn1134 }}</ref>  and
- | PDB = {{PDB2|2bmj}}, {{PDB2|2iwr}}
+* [[PIK3R1]].<ref name = pmid11136977>{{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | date = December 2000 | pmid = 11136977 | doi =  10.1016/S0092-8674(00)00195-1}}</ref>
- | Name = Centaurin, gamma 1
- | HGNCid = 16921
- | Symbol = CENTG1
- | AltSymbols =; AGAP2; FLJ16430; GGAP2; KIAA0167; PIKE
- | OMIM = 605476
- | ECnumber =
- | Homologene = 86981
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_CENTG1_206152_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CENTG1_215080_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
-  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 116986
-    | Hs_Ensembl = ENSG00000135439
-    | Hs_RefseqProtein = NP_055585
-    | Hs_RefseqmRNA = NM_014770
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 56405251
-    | Hs_GenLoc_end = 56422209
-    | Hs_Uniprot = Q99490
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Centaurin, gamma 1''', also known as '''CENTG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENTG1 centaurin, gamma 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116986| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== References ==
-{{PBB_Summary
+{{reflist}}
-| section_title =
-| summary_text =
-}}
-==References==
+==External links==
-{{reflist|2}}
+* {{UCSC gene info|AGAP2}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. | journal = DNA Res. | volume = 3 | issue = 1 | pages = 17–24 | year = 1996 | pmid = 8724849 | doi = 10.1093/dnares/3.1.17 }}
-| citations =
+* {{cite journal | vauthors = Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS | title = Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. | journal = Genomics | volume = 42 | issue = 2 | pages = 295–301 | year = 1997 | pmid = 9192850 | doi = 10.1006/geno.1997.4727 }}
-*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17-24 |year= 1996 |pmid= 8724849 |doi=  }}
+* {{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | year = 2001 | pmid = 11136977 | doi = 10.1016/S0092-8674(00)00195-1 }}
-*{{cite journal  | author=Elkahloun AG, Krizman DB, Wang Z, ''et al.'' |title=Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. |journal=Genomics |volume=42 |issue= 2 |pages= 295-301 |year= 1997 |pmid= 9192850 |doi= 10.1006/geno.1997.4727 }}
+* {{cite journal | vauthors = Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH | title = Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. | journal = Nature | volume = 415 | issue = 6871 | pages = 541–4 | year = 2002 | pmid = 11823862 | doi = 10.1038/415541a }}
-*{{cite journal  | author=Ye K, Hurt KJ, Wu FY, ''et al.'' |title=Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. |journal=Cell |volume=103 |issue= 6 |pages= 919-30 |year= 2001 |pmid= 11136977 |doi=  }}
+* {{cite journal | vauthors = Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA | title = AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. | journal = J. Biol. Chem. | volume = 277 | issue = 50 | pages = 48965–75 | year = 2003 | pmid = 12388557 | doi = 10.1074/jbc.M202969200 }}
-*{{cite journal  | author=Ye K, Aghdasi B, Luo HR, ''et al.'' |title=Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. |journal=Nature |volume=415 |issue= 6871 |pages= 541-4 |year= 2002 |pmid= 11823862 |doi= 10.1038/415541a }}
+* {{cite journal | vauthors = Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M | title = GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. | journal = Mol. Cell. Biol. | volume = 23 | issue = 7 | pages = 2476–88 | year = 2003 | pmid = 12640130 | pmc = 150724 | doi = 10.1128/MCB.23.7.2476-2488.2003 }}
-*{{cite journal  | author=Nie Z, Stanley KT, Stauffer S, ''et al.'' |title=AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48965-75 |year= 2003 |pmid= 12388557 |doi= 10.1074/jbc.M202969200 }}
+* {{cite journal | vauthors = Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K | title = PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. | journal = Nat. Neurosci. | volume = 6 | issue = 11 | pages = 1153–61 | year = 2003 | pmid = 14528310 | doi = 10.1038/nn1134 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K | title = PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. | journal = J. Biol. Chem. | volume = 279 | issue = 16 | pages = 16441–51 | year = 2004 | pmid = 14761976 | doi = 10.1074/jbc.M312175200 }}
-*{{cite journal  | author=Xia C, Ma W, Stafford LJ, ''et al.'' |title=GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 7 |pages= 2476-88 |year= 2003 |pmid= 12640130 |doi=  }}
+* {{cite journal | vauthors = Ahn JY, Hu Y, Kroll TG, Allard P, Ye K | title = PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 18 | pages = 6993–8 | year = 2004 | pmid = 15118108 | pmc = 406454 | doi = 10.1073/pnas.0400921101 }}
-*{{cite journal  | author=Rong R, Ahn JY, Huang H, ''et al.'' |title=PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. |journal=Nat. Neurosci. |volume=6 |issue= 11 |pages= 1153-61 |year= 2003 |pmid= 14528310 |doi= 10.1038/nn1134 }}
+* {{cite journal | vauthors = Nie Z, Fei J, Premont RT, Randazzo PA | title = The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. | journal = J. Cell Sci. | volume = 118 | issue = Pt 15 | pages = 3555–66 | year = 2005 | pmid = 16079295 | doi = 10.1242/jcs.02486 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Knobbe CB, Trampe-Kieslich A, Reifenberger G | title = Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. | journal = Neuropathol. Appl. Neurobiol. | volume = 31 | issue = 5 | pages = 486–90 | year = 2005 | pmid = 16150119 | doi = 10.1111/j.1365-2990.2005.00660.x }}
-*{{cite journal  | author=Ahn JY, Rong R, Kroll TG, ''et al.'' |title=PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16441-51 |year= 2004 |pmid= 14761976 |doi= 10.1074/jbc.M312175200 }}
+* {{cite journal | vauthors = Hu Y, Liu Z, Ye K | title = Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 46 | pages = 16853–8 | year = 2006 | pmid = 16263930 | pmc = 1283830 | doi = 10.1073/pnas.0507365102 }}
-*{{cite journal  | author=Ahn JY, Hu Y, Kroll TG, ''et al.'' |title=PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 6993-8 |year= 2004 |pmid= 15118108 |doi= 10.1073/pnas.0400921101 }}
+* {{cite journal | vauthors = Tang X, Feng Y, Ye K | title = Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. | journal = Cell Death Differ. | volume = 14 | issue = 2 | pages = 368–77 | year = 2007 | pmid = 16841086 | doi = 10.1038/sj.cdd.4402011 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal | vauthors = Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA | title = The centaurin gamma-1 GTPase-like domain functions as an NTPase. | journal = Biochem. J. | volume = 401 | issue = 3 | pages = 679–88 | year = 2007 | pmid = 17037982 | pmc = 1770848 | doi = 10.1042/BJ20060555 }}
-*{{cite journal  | author=Nie Z, Fei J, Premont RT, Randazzo PA |title=The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. |journal=J. Cell. Sci. |volume=118 |issue= Pt 15 |pages= 3555-66 |year= 2005 |pmid= 16079295 |doi= 10.1242/jcs.02486 }}
+* {{cite journal | vauthors = Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G | title = M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. | journal = J. Virol. | volume = 81 | issue = 5 | pages = 2340–8 | year = 2007 | pmid = 17151107 | pmc = 1865929 | doi = 10.1128/JVI.01310-06 }}
-*{{cite journal  | author=Knobbe CB, Trampe-Kieslich A, Reifenberger G |title=Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. |journal=Neuropathol. Appl. Neurobiol. |volume=31 |issue= 5 |pages= 486-90 |year= 2005 |pmid= 16150119 |doi= 10.1111/j.1365-2990.2005.00660.x }}
+* {{cite journal | vauthors = Liu X, Hu Y, Hao C, Rempel SA, Ye K | title = PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. | journal = Oncogene | volume = 26 | issue = 34 | pages = 4918–27 | year = 2007 | pmid = 17297440 | doi = 10.1038/sj.onc.1210290 }}
-*{{cite journal  | author=Hu Y, Liu Z, Ye K |title=Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 46 |pages= 16853-8 |year= 2006 |pmid= 16263930 |doi= 10.1073/pnas.0507365102 }}
+* {{cite journal | vauthors = Dunphy JL, Ye K, Casanova JE | title = Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. | journal = Traffic | volume = 8 | issue = 6 | pages = 661–72 | year = 2007 | pmid = 17461797 | doi = 10.1111/j.1600-0854.2007.00561.x }}
-*{{cite journal  | author=Tang X, Feng Y, Ye K |title=Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. |journal=Cell Death Differ. |volume=14 |issue= 2 |pages= 368-77 |year= 2007 |pmid= 16841086 |doi= 10.1038/sj.cdd.4402011 }}
-*{{cite journal  | author=Soundararajan M, Yang X, Elkins JM, ''et al.'' |title=The centaurin gamma-1 GTPase-like domain functions as an NTPase. |journal=Biochem. J. |volume=401 |issue= 3 |pages= 679-88 |year= 2007 |pmid= 17037982 |doi= 10.1042/BJ20060555 }}
-*{{cite journal  | author=Werden SJ, Barrett JW, Wang G, ''et al.'' |title=M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. |journal=J. Virol. |volume=81 |issue= 5 |pages= 2340-8 |year= 2007 |pmid= 17151107 |doi= 10.1128/JVI.01310-06 }}
-*{{cite journal  | author=Liu X, Hu Y, Hao C, ''et al.'' |title=PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. |journal=Oncogene |volume=26 |issue= 34 |pages= 4918-27 |year= 2007 |pmid= 17297440 |doi= 10.1038/sj.onc.1210290 }}
-*{{cite journal  | author=Dunphy JL, Ye K, Casanova JE |title=Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. |journal=Traffic |volume=8 |issue= 6 |pages= 661-72 |year= 2007 |pmid= 17461797 |doi= 10.1111/j.1600-0854.2007.00561.x }}
-}}
 {{refend}}
-{{protein-stub}}
+{{PDB Gallery|geneid=116986}}
-{{WikiDoc Sources}}
+{{gene-12-stub}}

CENTG1: Difference between revisions

Latest revision as of 19:33, 8 November 2017

Contents

Interactions

References

External links

Further reading

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