SMARCC2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''SWI/SNF complex subunit SMARCC2''' is a [[protein]] that in humans is encoded by the ''SMARCC2'' [[gene]].<ref name="pmid8804307">{{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes Dev | volume = 10 | issue = 17 | pages = 2117–30 | date = November 1996 | pmid = 8804307 | pmc =  | doi = 10.1101/gad.10.17.2117 }}</ref><ref name="pmid9693044">{{cite journal | vauthors = Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U | title = Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome | journal = Genomics | volume = 51 | issue = 1 | pages = 140–3 | date = September 1998 | pmid = 9693044 | pmc = | doi = 10.1006/geno.1998.5343 }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
| HGNCid = 11105
| Symbol = SMARCC2
| AltSymbols =; Rsc8; BAF170; CRACC2
| OMIM = 601734
| ECnumber = 
| Homologene = 2312
| MGIid = 1915344
| GeneAtlas_image1 = PBB_GE_SMARCC2_201321_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCC2_201320_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0016514 |text = SWI/SNF complex}} {{GNF_GO|id=GO:0017053 |text = transcriptional repressor complex}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6601
    | Hs_Ensembl = ENSG00000139613
    | Hs_RefseqProtein = NP_003066
    | Hs_RefseqmRNA = NM_003075
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 54843034
    | Hs_GenLoc_end = 54869618
    | Hs_Uniprot = Q8TAQ2
    | Mm_EntrezGene = 68094
    | Mm_Ensembl = ENSMUSG00000025369
    | Mm_RefseqmRNA = NM_198160
    | Mm_RefseqProtein = NP_937803
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 127862243
    | Mm_GenLoc_end = 127893123
    | Mm_Uniprot = Q6PDG5
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2''', also known as '''SMARCC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6601| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6601| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6601| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Wang W, Xue Y, Zhou S, ''et al.'' |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117-30 |year= 1996 |pmid= 8804307 |doi=  }}
*{{cite journal  | author=Wang W, Côté J, Xue Y, ''et al.'' |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370-82 |year= 1996 |pmid= 8895581 |doi=  }}
*{{cite journal  | author=Wang W, Chi T, Xue Y, ''et al.'' |title=Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 2 |pages= 492-8 |year= 1998 |pmid= 9435219 |doi=  }}
*{{cite journal  | author=Ring HZ, Vameghi-Meyers V, Wang W, ''et al.'' |title=Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. |journal=Genomics |volume=51 |issue= 1 |pages= 140-3 |year= 1998 |pmid= 9693044 |doi= 10.1006/geno.1998.5343 }}
*{{cite journal  | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
*{{cite journal  | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247-53 |year= 1999 |pmid= 10078207 |doi=  }}
*{{cite journal  | author=Bochar DA, Wang L, Beniya H, ''et al.'' |title=BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. |journal=Cell |volume=102 |issue= 2 |pages= 257-65 |year= 2000 |pmid= 10943845 |doi=  }}
*{{cite journal  | author=Kadam S, McAlpine GS, Phelan ML, ''et al.'' |title=Functional selectivity of recombinant mammalian SWI/SNF subunits. |journal=Genes Dev. |volume=14 |issue= 19 |pages= 2441-51 |year= 2000 |pmid= 11018012 |doi=  }}
*{{cite journal  | author=Xue Y, Canman JC, Lee CS, ''et al.'' |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015-20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 }}
*{{cite journal  | author=Sif S, Saurin AJ, Imbalzano AN, Kingston RE |title=Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. |journal=Genes Dev. |volume=15 |issue= 5 |pages= 603-18 |year= 2001 |pmid= 11238380 |doi= 10.1101/gad.872801 }}
*{{cite journal  | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal  | author=Battaglioli E, Andrés ME, Rose DW, ''et al.'' |title=REST repression of neuronal genes requires components of the hSWI.SNF complex. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 41038-45 |year= 2002 |pmid= 12192000 |doi= 10.1074/jbc.M205691200 }}
*{{cite journal  | author=Olave I, Wang W, Xue Y, ''et al.'' |title=Identification of a polymorphic, neuron-specific chromatin remodeling complex. |journal=Genes Dev. |volume=16 |issue= 19 |pages= 2509-17 |year= 2002 |pmid= 12368262 |doi= 10.1101/gad.992102 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nie Z, Yan Z, Chen EH, ''et al.'' |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942-52 |year= 2003 |pmid= 12665591 |doi=  }}
*{{cite journal  | author=Kitagawa H, Fujiki R, Yoshimura K, ''et al.'' |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905-17 |year= 2003 |pmid= 12837248 |doi=  }}
*{{cite journal  | author=Hsiao PW, Fryer CJ, Trotter KW, ''et al.'' |title=BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6210-20 |year= 2003 |pmid= 12917342 |doi=  }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Kuwabara T, Hsieh J, Nakashima K, ''et al.'' |title=A small modulatory dsRNA specifies the fate of adult neural stem cells. |journal=Cell |volume=116 |issue= 6 |pages= 779-93 |year= 2004 |pmid= 15035981 |doi=  }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
}}
{{refend}}


{{protein-stub}}
SMARCC2 has been shown to [[Protein-protein interaction|interact]] with [[BAZ1B]]<ref name=pmid12837248>{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | language =  | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | date = June 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}</ref> and [[SMARCA4]].<ref name=pmid8895581>{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | language =  | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | date = October 1996 | pmid = 8895581 | pmc = 452280 }}</ref><ref name=pmid11726552>{{cite journal | vauthors = Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM | title = Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex | language =  | journal = Hum. Mol. Genet. | volume = 10 | issue = 23 | pages = 2651–60 | date = November 2001 | pmid = 11726552 | doi = 10.1093/hmg/10.23.2651 | url =  | authorlink =  | laysummary =  | oclc =  | id =  | bibcode =  | accessdate =  | location = England | laydate =  | format =  | quote =  | publisher =  | issn = 0964-6906 | laysource =  }}</ref><ref name=pmid9845365>{{cite journal | vauthors = Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR | title = Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling | language =  | journal = Cell | volume = 95 | issue = 5 | pages = 625–36 | date = November 1998 | pmid = 9845365 | doi = 10.1016/S0092-8674(00)81633-5 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | year = 1996 | pmid = 8895581 | pmc = 452280 | doi =  }}
* {{cite journal | vauthors = Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR | title = Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 2 | pages = 492–8 | year = 1998 | pmid = 9435219 | pmc = 18447 | doi = 10.1073/pnas.95.2.492 }}
* {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | year = 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}
* {{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Mol. Cell | volume = 3 | issue = 2 | pages = 247–53 | year = 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 }}
* {{cite journal | vauthors = Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R | title = BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer | journal = Cell | volume = 102 | issue = 2 | pages = 257–65 | year = 2000 | pmid = 10943845 | doi = 10.1016/S0092-8674(00)00030-1 }}
* {{cite journal | vauthors = Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM | title = Functional selectivity of recombinant mammalian SWI/SNF subunits | journal = Genes Dev. | volume = 14 | issue = 19 | pages = 2441–51 | year = 2000 | pmid = 11018012 | pmc = 316972 | doi = 10.1101/gad.828000 }}
* {{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 24 | pages = 13015–20 | year = 2001 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 }}
* {{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes Dev. | volume = 15 | issue = 5 | pages = 603–18 | year = 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}
* {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5498–505 | year = 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
* {{cite journal | vauthors = Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G | title = REST repression of neuronal genes requires components of the hSWI.SNF complex | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 41038–45 | year = 2002 | pmid = 12192000 | doi = 10.1074/jbc.M205691200 }}
* {{cite journal | vauthors = Olave I, Wang W, Xue Y, Kuo A, Crabtree GR | title = Identification of a polymorphic, neuron-specific chromatin remodeling complex | journal = Genes Dev. | volume = 16 | issue = 19 | pages = 2509–17 | year = 2002 | pmid = 12368262 | pmc = 187451 | doi = 10.1101/gad.992102 }}
* {{cite journal | vauthors = Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W | title = Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner | journal = Mol. Cell. Biol. | volume = 23 | issue = 8 | pages = 2942–52 | year = 2003 | pmid = 12665591 | pmc = 152562 | doi = 10.1128/MCB.23.8.2942-2952.2003 }}
* {{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | year = 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}
* {{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation | journal = Mol. Cell. Biol. | volume = 23 | issue = 17 | pages = 6210–20 | year = 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
* {{cite journal | vauthors = Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH | title = A small modulatory dsRNA specifies the fate of adult neural stem cells | journal = Cell | volume = 116 | issue = 6 | pages = 779–93 | year = 2004 | pmid = 15035981 | doi = 10.1016/S0092-8674(04)00248-X }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
{{Refend}}
 
== External links ==
* {{FactorBook|BAF170}}
 
 
{{Gene-12-stub}}

Revision as of 06:39, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

SMARCC2 has been shown to interact with BAZ1B[4] and SMARCA4.[5][6][7]

References

  1. ↑ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (November 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  2. ↑ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (September 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
  3. ↑ 3.0 3.1 "Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2".
  4. ↑ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
  5. ↑ Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
  6. ↑ Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (November 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. England. 10 (23): 2651–60. doi:10.1093/hmg/10.23.2651. ISSN 0964-6906. PMID 11726552.
  7. ↑ Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (November 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell. 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=SMARCC2&oldid=1415728"