UVRAG: Difference between revisions

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{{Infobox_gene}}
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'''UV radiation resistance-associated gene protein''' is a [[protein]] that in humans is encoded by the ''UVRAG'' [[gene]].<ref name="pmid9169138">{{cite journal |vauthors=Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D | title = Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus | journal = Genomics | volume = 41 | issue = 3 | pages = 397–405 |date=Jul 1997 | pmid = 9169138 | pmc =  | doi = 10.1006/geno.1997.4623 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = UV radiation resistance associated gene
| HGNCid = 12640
| Symbol = UVRAG
| AltSymbols =; DHTX; p63
| OMIM = 602493
| ECnumber = 
| Homologene = 31150
| MGIid = 1925860
| GeneAtlas_image1 = PBB_GE_UVRAG_203241_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7405
    | Hs_Ensembl = ENSG00000198382
    | Hs_RefseqProtein = NP_003360
    | Hs_RefseqmRNA = NM_003369
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 75203923
    | Hs_GenLoc_end = 75531342
    | Hs_Uniprot = Q9P2Y5
    | Mm_EntrezGene = 78610
    | Mm_Ensembl = ENSMUSG00000035354
    | Mm_RefseqmRNA = NM_178635
    | Mm_RefseqProtein = NP_848750
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 98761945
    | Mm_GenLoc_end = 99016313
    | Mm_Uniprot = 
  }}
}}
'''UV radiation resistance associated gene''', also known as '''UVRAG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.<ref name="entrez">{{cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = }}</ref>
| summary_text = This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Liang C, Feng P, Ku B, ''et al.'' |title=UVRAG: a new player in autophagy and tumor cell growth. |journal=Autophagy |volume=3 |issue= 1 |pages= 69-71 |year= 2007 |pmid= 17106237 |doi=  }}
*{{cite journal  | author=Liang C |title=UVRAG: a new player in autophagy and tumor cell growth |journal=Autophagy |volume=3 |issue= 1 |pages= 69–71 |year= 2007 |pmid= 17106237 |doi= 10.4161/auto.3437|name-list-format=vanc| author2=Feng P  | author3=Ku B  | display-authors=3  | last4=Oh  | first4=BH  | last5=Jung  | first5=JU }}
*{{cite journal  | author=Teitz T, Penner M, Eli D, ''et al.'' |title=Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. |journal=Gene |volume=87 |issue= 2 |pages= 295-8 |year= 1990 |pmid= 2332174 |doi=  }}
*{{cite journal  | author=Teitz T |title=Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells |journal=Gene |volume=87 |issue= 2 |pages= 295–298 |year= 1990 |pmid= 2332174 |doi=10.1016/0378-1119(90)90316-J  |name-list-format=vanc| author2=Penner M  | author3=Eli D  | display-authors=3  | last4=Stark  | first4=Merav  | last5=Bakhanashvili  | first5=Mary  | last6=Naiman  | first6=Tova  | last7=Canaani  | first7=Dan }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Perelman B, Dafni N, Naiman T, ''et al.'' |title=Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. |journal=Genomics |volume=41 |issue= 3 |pages= 397-405 |year= 1997 |pmid= 9169138 |doi= 10.1006/geno.1997.4623 }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Bekri S |title=Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1–2 |pages= 125–131 |year= 1998 |pmid= 9533029 |doi=10.1159/000134699  |name-list-format=vanc| author2=Adélaïde J  | author3=Merscher S  | display-authors=3  | last4=Grosgeorge  | first4=J.  | last5=Caroli-Bosc  | first5=F.  | last6=Perucca-Lostanlen  | first6=D.P.  | last7=Kelley  | first7=P.M.  | last8=p&Eacute;Busque  | first8=M.-J.  | last9=Theillet  | first9=C. }}
*{{cite journal  | author=Bekri S, Adélaïde J, Merscher S, ''et al.'' |title=Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 125-31 |year= 1998 |pmid= 9533029 |doi=  }}
*{{cite journal  | author=Iida A |title=Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation |journal=Hum. Genet. |volume=106 |issue= 3 |pages= 277–287 |year= 2000 |pmid= 10798355 |doi=10.1007/s004390051038  |name-list-format=vanc| author2=Emi M  | author3=Matsuoka R  | display-authors=3  | last4=Hiratsuka  | first4=E.  | last5=Okui  | first5=K.  | last6=Ohashi  | first6=H.  | last7=Inazawa  | first7=J.  | last8=Fukushima  | first8=Y.  | last9=Imai  | first9=T. }}
*{{cite journal  | author=Iida A, Emi M, Matsuoka R, ''et al.'' |title=Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. |journal=Hum. Genet. |volume=106 |issue= 3 |pages= 277-87 |year= 2000 |pmid= 10798355 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Goi T |title=Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case |journal=Surg. Today |volume=33 |issue= 9 |pages= 702–706 |year= 2004 |pmid= 12928850 |doi= 10.1007/s00595-002-2567-y |name-list-format=vanc| author2=Kawasaki M  | author3=Yamazaki T  | display-authors=3  | last4=Koneri  | first4=Kenji  | last5=Katayama  | first5=Kanji  | last6=Hirose  | first6=Kazuo  | last7=Yamaguchi  | first7=Akio }}
*{{cite journal  | author=Goi T, Kawasaki M, Yamazaki T, ''et al.'' |title=Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case. |journal=Surg. Today |volume=33 |issue= 9 |pages= 702-6 |year= 2004 |pmid= 12928850 |doi= 10.1007/s00595-002-2567-y }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ionov Y |title=Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability |journal=Oncogene |volume=23 |issue= 3 |pages= 639–645 |year= 2004 |pmid= 14737099 |doi= 10.1038/sj.onc.1207178 |name-list-format=vanc| author2=Nowak N  | author3=Perucho M  | display-authors=3  | last4=Markowitz  | first4=Sanford  | last5=Cowell  | first5=John K }}
*{{cite journal  | author=Ionov Y, Nowak N, Perucho M, ''et al.'' |title=Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. |journal=Oncogene |volume=23 |issue= 3 |pages= 639-45 |year= 2004 |pmid= 14737099 |doi= 10.1038/sj.onc.1207178 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Liang C |title=Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG |journal=Nat. Cell Biol. |volume=8 |issue= 7 |pages= 688–698 |year= 2006 |pmid= 16799551 |doi= 10.1038/ncb1426 |name-list-format=vanc| author2=Feng P  | author3=Ku B  | display-authors=3  | last4=Dotan  | first4=Iris  | last5=Canaani  | first5=Dan  | last6=Oh  | first6=Byung-Ha  | last7=Jung  | first7=Jae U. }}
*{{cite journal  | author=Liang C, Feng P, Ku B, ''et al.'' |title=Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. |journal=Nat. Cell Biol. |volume=8 |issue= 7 |pages= 688-99 |year= 2006 |pmid= 16799551 |doi= 10.1038/ncb1426 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 10:25, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.[1][2]

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[2]

References

  1. ↑ Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D (Jul 1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus". Genomics. 41 (3): 397–405. doi:10.1006/geno.1997.4623. PMID 9169138.
  2. ↑ 2.0 2.1 "Entrez Gene: UVRAG UV radiation resistance associated gene".

Further reading



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