Teratocarcinoma-derived growth factor 1: Difference between revisions

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{{Infobox_gene}}
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'''Teratocarcinoma-derived growth factor 1''' is a [[protein]] that in humans is encoded by the ''TDGF1'' [[gene]].<ref name="pmid1882841">{{cite journal | vauthors = Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG | title = Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence | journal = Am J Hum Genet | volume = 49 | issue = 3 | pages = 555–65 |date=Oct 1991 | pmid = 1882841 | pmc = 1683146 | doi =  }}</ref><ref name="pmid10393436">{{cite journal | vauthors = Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG | title = Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1 | journal = Cytogenet Cell Genet | volume = 84 | issue = 3-4 | pages = 220–4 |date=Jul 1999 | pmid = 10393436 | pmc = | doi =10.1159/000015263  }}</ref> The protein is an [[extracellular]], [[Membrane protein|membrane-bound]] signaling protein that plays an essential role in [[Embryogenesis|embryonic development]] and [[tumor]] growth. Mutations in this gene are associated with [[forebrain]] defects. [[Pseudogene]]s of this gene are found on [[chromosome 2|chromosomes 2]], [[chromosome 3|3]], [[chromosome 6|6]], [[chromosome 8|8]], [[chromosome 19|19]] and [[X chromosome|X]]. [[Alternate splicing]] results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6997| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Teratocarcinoma-derived growth factor 1
| HGNCid = 11701
| Symbol = TDGF1
| AltSymbols =; CR; CRGF; CRIPTO; Cripto-1
| OMIM = 187395
| ECnumber =
| Homologene = 2416
| MGIid = 98658
| GeneAtlas_image1 = PBB_GE_TDGF1_206286_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
  | Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0019897 |text = extrinsic to plasma membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0001763 |text = morphogenesis of a branching structure}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008595 |text = determination of anterior/posterior axis, embryo}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0009966 |text = regulation of signal transduction}} {{GNF_GO|id=GO:0018105 |text = peptidyl-serine phosphorylation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6997
    | Hs_Ensembl = ENSG00000163828
    | Hs_RefseqProtein = NP_003203
    | Hs_RefseqmRNA = NM_003212
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 46594282
    | Hs_GenLoc_end = 46598715
    | Hs_Uniprot = P13385
    | Mm_EntrezGene = 21667
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011562
    | Mm_RefseqProtein = NP_035692
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Teratocarcinoma-derived growth factor 1''', also known as '''TDGF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6997| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Salomon DS, Bianco C, De Santis M |title=Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. |journal=Bioessays |volume=21 |issue= 1 |pages= 61-70 |year= 1999 |pmid= 10070255 |doi= 10.1002/(SICI)1521-1878(199901)21:1<61::AID-BIES8>3.0.CO;2-H }}
*{{cite journal  | vauthors=Salomon DS, Bianco C, De Santis M |title=Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. |journal=BioEssays |volume=21 |issue= 1 |pages= 61–70 |year= 1999 |pmid= 10070255 |doi= 10.1002/(SICI)1521-1878(199901)21:1<61::AID-BIES8>3.0.CO;2-H }}
*{{cite journal  | author=Adamson ED, Minchiotti G, Salomon DS |title=Cripto: a tumor growth factor and more. |journal=J. Cell. Physiol. |volume=190 |issue= 3 |pages= 267-78 |year= 2002 |pmid= 11857442 |doi= 10.1002/jcp.10072 }}
*{{cite journal  | vauthors=Adamson ED, Minchiotti G, Salomon DS |title=Cripto: a tumor growth factor and more. |journal=J. Cell. Physiol. |volume=190 |issue= 3 |pages= 267–78 |year= 2002 |pmid= 11857442 |doi= 10.1002/jcp.10072 }}
*{{cite journal | author=Dono R, Montuori N, Rocchi M, ''et al.'' |title=Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. |journal=Am. J. Hum. Genet. |volume=49 |issue= 3 |pages= 555-65 |year= 1991 |pmid= 1882841 |doi=  }}
*{{cite journal   |vauthors=Ciccodicola A, Dono R, Obici S, etal |title=Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. |journal=EMBO J. |volume=8 |issue= 7 |pages= 1987–91 |year= 1989 |pmid= 2792079 |doi= | pmc=401069 }}
*{{cite journal  | author=Ciccodicola A, Dono R, Obici S, ''et al.'' |title=Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. |journal=EMBO J. |volume=8 |issue= 7 |pages= 1987-91 |year= 1989 |pmid= 2792079 |doi=  }}
*{{cite journal   |vauthors=Saccone S, Rapisarda A, Motta S, etal |title=Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21. |journal=Hum. Genet. |volume=95 |issue= 2 |pages= 229–30 |year= 1995 |pmid= 7860072 |doi=10.1007/BF00209409 }}
*{{cite journal | author=Saccone S, Rapisarda A, Motta S, ''et al.'' |title=Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21. |journal=Hum. Genet. |volume=95 |issue= 2 |pages= 229-30 |year= 1995 |pmid= 7860072 |doi=  }}
*{{cite journal   |vauthors=Brandt R, Normanno N, Gullick WJ, etal |title=Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17320–8 |year= 1994 |pmid= 8006041 |doi=  }}
*{{cite journal | author=Brandt R, Normanno N, Gullick WJ, ''et al.'' |title=Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17320-8 |year= 1994 |pmid= 8006041 |doi=  }}
*{{cite journal   |vauthors=Friess H, Yamanaka Y, Büchler M, etal |title=Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. |journal=Int. J. Cancer |volume=56 |issue= 5 |pages= 668–74 |year= 1994 |pmid= 8314343 |doi=10.1002/ijc.2910560511 }}
*{{cite journal | author=Friess H, Yamanaka Y, Büchler M, ''et al.'' |title=Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. |journal=Int. J. Cancer |volume=56 |issue= 5 |pages= 668-74 |year= 1994 |pmid= 8314343 |doi=  }}
*{{cite journal   |vauthors=Panico L, D'Antonio A, Salvatore G, etal |title=Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. |journal=Int. J. Cancer |volume=65 |issue= 1 |pages= 51–6 |year= 1996 |pmid= 8543395 |doi= 10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0 }}
*{{cite journal | author=Panico L, D'Antonio A, Salvatore G, ''et al.'' |title=Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. |journal=Int. J. Cancer |volume=65 |issue= 1 |pages= 51-6 |year= 1996 |pmid= 8543395 |doi= 10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0 }}
*{{cite journal   |vauthors=Kannan S, De Santis M, Lohmeyer M, etal |title=Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3330–5 |year= 1997 |pmid= 9013573 |doi=10.1074/jbc.272.6.3330 }}
*{{cite journal | author=Kannan S, De Santis M, Lohmeyer M, ''et al.'' |title=Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3330-5 |year= 1997 |pmid= 9013573 |doi=  }}
*{{cite journal  | vauthors=Xu C, Liguori G, Adamson ED, Persico MG |title=Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. |journal=Dev. Biol. |volume=196 |issue= 2 |pages= 237–47 |year= 1998 |pmid= 9576836 |doi= 10.1006/dbio.1998.8862 }}
*{{cite journal  | author=Xu C, Liguori G, Adamson ED, Persico MG |title=Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. |journal=Dev. Biol. |volume=196 |issue= 2 |pages= 237-47 |year= 1998 |pmid= 9576836 |doi= 10.1006/dbio.1998.8862 }}
*{{cite journal  | vauthors=Xu C, Liguori G, Persico MG, Adamson ED |title=Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. |journal=Development |volume=126 |issue= 3 |pages= 483–94 |year= 1999 |pmid= 9876177 |doi=  }}
*{{cite journal  | author=Xu C, Liguori G, Persico MG, Adamson ED |title=Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. |journal=Development |volume=126 |issue= 3 |pages= 483-94 |year= 1999 |pmid= 9876177 |doi=  }}
*{{cite journal   |vauthors=Ebert AD, Wechselberger C, Frank S, etal |title=Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. |journal=Cancer Res. |volume=59 |issue= 18 |pages= 4502–5 |year= 1999 |pmid= 10493495 |doi=  }}
*{{cite journal | author=Scognamiglio B, Baldassarre G, Cassano C, ''et al.'' |title=Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 220-4 |year= 1999 |pmid= 10393436 |doi=  }}
*{{cite journal   |vauthors=Reissmann E, Jörnvall H, Blokzijl A, etal |title=The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. |journal=Genes Dev. |volume=15 |issue= 15 |pages= 2010–22 |year= 2001 |pmid= 11485994 |doi= 10.1101/gad.201801 | pmc=312747 }}
*{{cite journal  | author=Ebert AD, Wechselberger C, Frank S, ''et al.'' |title=Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. |journal=Cancer Res. |volume=59 |issue= 18 |pages= 4502-5 |year= 1999 |pmid= 10493495 |doi=  }}
*{{cite journal   |vauthors=Bianco C, Adkins HB, Wechselberger C, etal |title=Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2586–97 |year= 2002 |pmid= 11909953 |doi=10.1128/MCB.22.8.2586-2597.2002  | pmc=133714 }}
*{{cite journal | author=Reissmann E, Jörnvall H, Blokzijl A, ''et al.'' |title=The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. |journal=Genes Dev. |volume=15 |issue= 15 |pages= 2010-22 |year= 2001 |pmid= 11485994 |doi= 10.1101/gad.201801 }}
*{{cite journal   |vauthors=Yan YT, Liu JJ, Luo Y, etal |title=Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4439–49 |year= 2002 |pmid= 12052855 |doi=10.1128/MCB.22.13.4439-4449.2002  | pmc=133918 }}
*{{cite journal | author=Bianco C, Adkins HB, Wechselberger C, ''et al.'' |title=Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2586-97 |year= 2002 |pmid= 11909953 |doi=  }}
*{{cite journal   |vauthors=de la Cruz JM, Bamford RN, Burdine RD, etal |title=A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. |journal=Hum. Genet. |volume=110 |issue= 5 |pages= 422–8 |year= 2002 |pmid= 12073012 |doi= 10.1007/s00439-002-0709-3 }}
*{{cite journal | author=Yan YT, Liu JJ, Luo Y, ''et al.'' |title=Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4439-49 |year= 2002 |pmid= 12052855 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=de la Cruz JM, Bamford RN, Burdine RD, ''et al.'' |title=A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. |journal=Hum. Genet. |volume=110 |issue= 5 |pages= 422-8 |year= 2002 |pmid= 12073012 |doi= 10.1007/s00439-002-0709-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 16:11, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene.[1][2] The protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.[3]


References

  1. ↑ Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG (Oct 1991). "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence". Am J Hum Genet. 49 (3): 555–65. PMC 1683146. PMID 1882841.
  2. ↑ Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG (Jul 1999). "Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1". Cytogenet Cell Genet. 84 (3–4): 220–4. doi:10.1159/000015263. PMID 10393436.
  3. ↑ "Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1".

Further reading



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