RGS7: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Regulator of G-protein signaling 7''' is a [[protein]] that in humans is encoded by the ''RGS7'' [[gene]].<ref name="pmid8548815">{{cite journal | vauthors = Koelle MR, Horvitz HR | title = EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins | journal = Cell | volume = 84 | issue = 1 | pages = 115–25 | date = Feb 1996 | pmid = 8548815 | pmc =  | doi = 10.1016/S0092-8674(00)80998-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS7 regulator of G-protein signalling 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6000| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled [[G protein-coupled receptor|GPCR]]. RGS7 is a [[GTPase-activating protein]] (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.<ref>{{cite journal | vauthors = Anderson GR, Posokhova E, Martemyanov KA | title = The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling | journal = Cell Biochemistry and Biophysics | volume = 54 | issue = 1-3 | pages = 33–46 | date = July 2009 | pmid = 19521673 | pmc = 2827338 | doi = 10.1007/s12013-009-9052-9 | url = https://link.springer.com/article/10.1007%2Fs12013-009-9052-9 }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_RGS7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2a72.
| PDB = {{PDB2|2a72}}, {{PDB2|2d9j}}
| Name = Regulator of G-protein signalling 7
| HGNCid = 10003
| Symbol = RGS7
| AltSymbols =;
| OMIM = 602517
| ECnumber = 
| Homologene = 2193
| MGIid = 1346089
| GeneAtlas_image1 = PBB_GE_RGS7_206290_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0016299 |text = regulator of G-protein signaling activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6000
    | Hs_Ensembl = ENSG00000182901
    | Hs_RefseqProtein = NP_002915
    | Hs_RefseqmRNA = NM_002924
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 239005438
    | Hs_GenLoc_end = 239587153
    | Hs_Uniprot = P49802
    | Mm_EntrezGene = 24012
    | Mm_Ensembl = ENSMUSG00000026527
    | Mm_RefseqmRNA = NM_011880
    | Mm_RefseqProtein = NP_036010
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 176896411
    | Mm_GenLoc_end = 177327805
    | Mm_Uniprot = O54829
  }}
}}
'''Regulator of G-protein signalling 7''', also known as '''RGS7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGS7 regulator of G-protein signalling 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6000| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
RGS7 has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[GNB5]],<ref name = pmid10051672>{{cite journal | vauthors = Levay K, Cabrera JL, Satpaev DK, Slepak VZ | title = Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 2503–7 | date = Mar 1999 | pmid = 10051672 | pmc = 26814 | doi =  10.1073/pnas.96.5.2503}}</ref><ref name = pmid10521509>{{cite journal | vauthors = Posner BA, Gilman AG, Harris BA | title = Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 31087–93 | date = Oct 1999 | pmid = 10521509 | doi =  10.1074/jbc.274.43.31087}}</ref>
==Further reading==
* [[GPR158]],<ref name=":0">{{cite journal | vauthors = Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA | title = GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes | journal = J. Cell Biol. | volume = 197 | issue = 6 | pages = 711–9 | date = June 11, 2012 | pmid = 22689652 | pmc = 3373406 | doi = 10.1083/jcb.201202123 }}</ref>
* [[GPR179]],<ref name=":0" />
* [[PKD1]],<ref name = pmid10339594>{{cite journal | vauthors = Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G | title = Interaction between RGS7 and polycystin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 11 | pages = 6371–6 | date = May 1999 | pmid = 10339594 | pmc = 26888 | doi =  10.1073/pnas.96.11.6371}}</ref>  and
* [[SNAPAP]].<ref name = pmid12659861>{{cite journal | vauthors = Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH | title = Snapin interacts with the N-terminus of regulator of G protein signaling 7 | journal = Biochem. Biophys. Res. Commun. | volume = 303 | issue = 2 | pages = 594–9 | date = Apr 2003 | pmid = 12659861 | doi =  10.1016/S0006-291X(03)00400-5}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI | title = RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells | journal = J. Neurochem. | volume = 70 | issue = 5 | pages = 1964–72 | year = 1998 | pmid = 9572280 | doi = 10.1046/j.1471-4159.1998.70051964.x }}
| citations =
* {{cite journal | vauthors = Levay K, Cabrera JL, Satpaev DK, Slepak VZ | title = Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 2503–7 | year = 1999 | pmid = 10051672 | pmc = 26814 | doi = 10.1073/pnas.96.5.2503 }}
*{{cite journal | author=Koelle MR, Horvitz HR |title=EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. |journal=Cell |volume=84 |issue= 1 |pages= 115-25 |year= 1996 |pmid= 8548815 |doi= }}
* {{cite journal | vauthors = Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T | title = RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents | journal = J. Biol. Chem. | volume = 274 | issue = 14 | pages = 9899–904 | year = 1999 | pmid = 10092682 | doi = 10.1074/jbc.274.14.9899 }}
*{{cite journal | author=Shuey DJ, Betty M, Jones PG, ''et al.'' |title=RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. |journal=J. Neurochem. |volume=70 |issue= 5 |pages= 1964-72 |year= 1998 |pmid= 9572280 |doi= }}
* {{cite journal | vauthors = Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G | title = Interaction between RGS7 and polycystin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 11 | pages = 6371–6 | year = 1999 | pmid = 10339594 | pmc = 26888 | doi = 10.1073/pnas.96.11.6371 }}
*{{cite journal | author=Levay K, Cabrera JL, Satpaev DK, Slepak VZ |title=Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 2503-7 |year= 1999 |pmid= 10051672 |doi= }}
* {{cite journal | vauthors = Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP | title = Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 11 | pages = 6489–94 | year = 1999 | pmid = 10339615 | pmc = 26909 | doi = 10.1073/pnas.96.11.6489 }}
*{{cite journal | author=Saitoh O, Kubo Y, Odagiri M, ''et al.'' |title=RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9899-904 |year= 1999 |pmid= 10092682 |doi= }}
* {{cite journal | vauthors = Posner BA, Gilman AG, Harris BA | title = Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 31087–93 | year = 1999 | pmid = 10521509 | doi = 10.1074/jbc.274.43.31087 }}
*{{cite journal | author=Kim E, Arnould T, Sellin L, ''et al.'' |title=Interaction between RGS7 and polycystin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6371-6 |year= 1999 |pmid= 10339594 |doi= }}
* {{cite journal | vauthors = Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G | title = 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity | journal = J. Biol. Chem. | volume = 275 | issue = 36 | pages = 28167–72 | year = 2000 | pmid = 10862767 | doi = 10.1074/jbc.M002905200 }}
*{{cite journal | author=Snow BE, Betts L, Mangion J, ''et al.'' |title=Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6489-94 |year= 1999 |pmid= 10339615 |doi= }}
* {{cite journal | vauthors = Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR | title = RGS7 is palmitoylated and exists as biochemically distinct forms | journal = J. Neurochem. | volume = 75 | issue = 5 | pages = 2103–12 | year = 2000 | pmid = 11032900 | doi = 10.1046/j.1471-4159.2000.0752103.x }}
*{{cite journal | author=Posner BA, Gilman AG, Harris BA |title=Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31087-93 |year= 1999 |pmid= 10521509 |doi= }}
* {{cite journal | vauthors = Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF | title = Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 10284–9 | year = 2001 | pmid = 11152459 | doi = 10.1074/jbc.M009247200 }}
*{{cite journal | author=Benzing T, Yaffe MB, Arnould T, ''et al.'' |title=14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28167-72 |year= 2000 |pmid= 10862767 |doi= 10.1074/jbc.M002905200 }}
* {{cite journal | vauthors = Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E | title = Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32954–62 | year = 2002 | pmid = 12077120 | doi = 10.1074/jbc.M200859200 }}
*{{cite journal | author=Rose JJ, Taylor JB, Shi J, ''et al.'' |title=RGS7 is palmitoylated and exists as biochemically distinct forms. |journal=J. Neurochem. |volume=75 |issue= 5 |pages= 2103-12 |year= 2000 |pmid= 11032900 |doi= }}
* {{cite journal | vauthors = Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH | title = Snapin interacts with the N-terminus of regulator of G protein signaling 7 | journal = Biochem. Biophys. Res. Commun. | volume = 303 | issue = 2 | pages = 594–9 | year = 2003 | pmid = 12659861 | doi = 10.1016/S0006-291X(03)00400-5 }}
*{{cite journal | author=Zhang JH, Barr VA, Mo Y, ''et al.'' |title=Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10284-9 |year= 2001 |pmid= 11152459 |doi= 10.1074/jbc.M009247200 }}
* {{cite journal | vauthors = Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ | title = G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction | journal = J. Biol. Chem. | volume = 278 | issue = 23 | pages = 21307–13 | year = 2003 | pmid = 12670932 | doi = 10.1074/jbc.M212884200 }}
*{{cite journal | author=Benzing T, Köttgen M, Johnson M, ''et al.'' |title=Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32954-62 |year= 2002 |pmid= 12077120 |doi= 10.1074/jbc.M200859200 }}
* {{cite journal | vauthors = Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A | title = The human plasma proteome: a nonredundant list developed by combination of four separate sources | journal = Mol. Cell. Proteomics | volume = 3 | issue = 4 | pages = 311–26 | year = 2004 | pmid = 14718574 | doi = 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Takida S, Fischer CC, Wedegaertner PB | title = Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo | journal = Mol. Pharmacol. | volume = 67 | issue = 1 | pages = 132–9 | year = 2005 | pmid = 15496508 | pmc = 1405920 | doi = 10.1124/mol.104.003418 }}
*{{cite journal | author=Hunt RA, Edris W, Chanda PK, ''et al.'' |title=Snapin interacts with the N-terminus of regulator of G protein signaling 7. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 2 |pages= 594-9 |year= 2003 |pmid= 12659861 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Witherow DS, Tovey SC, Wang Q, ''et al.'' |title=G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction. |journal=J. Biol. Chem. |volume=278 |issue= 23 |pages= 21307-13 |year= 2003 |pmid= 12670932 |doi= 10.1074/jbc.M212884200 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
* {{cite journal | vauthors = Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ | title = R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism | journal = J. Biol. Chem. | volume = 281 | issue = 38 | pages = 28222–31 | year = 2006 | pmid = 16867977 | doi = 10.1074/jbc.M604428200 }}
*{{cite journal | author=Takida S, Fischer CC, Wedegaertner PB |title=Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 132-9 |year= 2005 |pmid= 15496508 |doi= 10.1124/mol.104.003418 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Drenan RM, Doupnik CA, Jayaraman M, ''et al.'' |title=R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism. |journal=J. Biol. Chem. |volume=281 |issue= 38 |pages= 28222-31 |year= 2006 |pmid= 16867977 |doi= 10.1074/jbc.M604428200 }}
}}
{{refend}}
{{refend}}


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Revision as of 09:10, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.[1][2]

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.[3]

Interactions

RGS7 has been shown to interact with:

References

  1. ↑ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815.
  2. ↑ "Entrez Gene: RGS7 regulator of G-protein signalling 7".
  3. ↑ Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673.
  4. ↑ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
  5. ↑ Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
  6. ↑ 6.0 6.1 Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
  7. ↑ Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
  8. ↑ Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.

Further reading


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