Zollinger-Ellison syndrome causes: Difference between revisions

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*The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by  multiple endocrine [[neoplasia]] type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref>
*The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by  multiple endocrine [[neoplasia]] type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref>


*'''Causes of Hypergastrinemia:''' <ref name="pmid21806955">{{cite journal| author=Metz DC| title=Diagnosis of the Zollinger–Ellison syndrome. | journal=Clin Gastroenterol Hepatol | year= 2012 | volume= 10 | issue= 2 | pages= 126-30 | pmid=21806955 | doi=10.1016/j.cgh.2011.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21806955  }} </ref>
*Hypergastrinemia (an increased fasting serum gastrin level) is the hallmark of ZES. <ref name="pmid21806955">{{cite journal |vauthors=Metz DC |title=Diagnosis of the Zollinger–Ellison syndrome |journal=Clin. Gastroenterol. Hepatol. |volume=10 |issue=2 |pages=126–30 |year=2012 |pmid=21806955 |doi=10.1016/j.cgh.2011.07.012 |url=}}</ref>
:*'''Causes of Hypergastrinemia:''' <ref name="pmid21806955">{{cite journal| author=Metz DC| title=Diagnosis of the Zollinger–Ellison syndrome. | journal=Clin Gastroenterol Hepatol | year= 2012 | volume= 10 | issue= 2 | pages= 126-30 | pmid=21806955 | doi=10.1016/j.cgh.2011.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21806955  }} </ref>


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Revision as of 19:08, 3 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]

Overview

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).

Causes

  • The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
  • Hypergastrinemia (an increased fasting serum gastrin level) is the hallmark of ZES. [2]
  • Causes of Hypergastrinemia: [2]
Causes of Hypergastrinemia
Appropriate Hypergastrinemia
  • Atrophic gastritis with or without pernicious anemia
  • Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist)
  • Chronic renal failure
  • H pylori pangastritis
  • Vagotomy
Inappropriate Hypergastrinemia
  • ZES (sporadic or associated with MEN-1)
  • Antral-predominant H pylori infection
  • Retained-antrum syndrome
  • Gastric-outlet obstruction
  • Small-bowel resection
Spurious hypergastrinemia
  • Nonfasting patient
  • Inaccurate assay

References

  1. National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
  2. 2.0 2.1 Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin. Gastroenterol. Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.

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