Zollinger-Ellison syndrome causes: Difference between revisions
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The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref> | The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref> | ||
==Causes== | ==Causes== | ||
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref> | *The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref> | ||
*Causes of Hypergastrinemia: <ref name="pmid21806955">{{cite journal| author=Metz DC| title=Diagnosis of the Zollinger–Ellison syndrome. | journal=Clin Gastroenterol Hepatol | year= 2012 | volume= 10 | issue= 2 | pages= 126-30 | pmid=21806955 | doi=10.1016/j.cgh.2011.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21806955 }} </ref> | |||
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| colspan="3" style="background: #4479BA; text-align: center;" | {{fontcolor|#FFF|'''Causes of Hypergastrinemia'''}} | |||
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|'''Appropriate hypergastrinemia''' | |||
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|Atrophic gastritis with or without pernicious anemia | |||
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|Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist) | |||
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|Chronic renal failure | |||
|- | |||
|H pylori pangastritis | |||
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|Vagotomy | |||
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| | |||
|- | |||
|'''Inappropriate hypergastrinemia''' | |||
|- | |||
|ZES (sporadic or associated with MEN-1) | |||
|- | |||
|Antral-predominant H pylori infection | |||
|- | |||
|Retained-antrum syndrome | |||
|- | |||
|Gastric-outlet obstruction | |||
|- | |||
|Small-bowel resection | |||
|- | |||
| | |||
|- | |||
|'''Spurious hypergastrinemia''' | |||
|- | |||
|Nonfasting patient | |||
|- | |||
|Inaccurate assay | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 16:03, 20 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
Causes
- The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
- Causes of Hypergastrinemia: [2]
| Causes of Hypergastrinemia | ||
| Appropriate hypergastrinemia | ||
| Atrophic gastritis with or without pernicious anemia | ||
| Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist) | ||
| Chronic renal failure | ||
| H pylori pangastritis | ||
| Vagotomy | ||
| Inappropriate hypergastrinemia | ||
| ZES (sporadic or associated with MEN-1) | ||
| Antral-predominant H pylori infection | ||
| Retained-antrum syndrome | ||
| Gastric-outlet obstruction | ||
| Small-bowel resection | ||
| Spurious hypergastrinemia | ||
| Nonfasting patient | ||
| Inaccurate assay | ||
References
- ↑ 1.0 1.1 National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
- ↑ Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin Gastroenterol Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.