Graft-versus-host disease epidemiology and demographics: Difference between revisions
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===Case Fatality Rate=== | ===Case Fatality Rate=== | ||
*The annual case fatality rate of GvHD is approximately 50%. | |||
===Age=== | ===Age=== | ||
* GvHD is more likely to occur in persons of older age. However, given that this is not a natural disease, but rather an iatrogenic disease, GvHD can occur at any age, depending on when a patient underwent a bone marrow transplant. | * GvHD is more likely to occur in persons of older age. However, given that this is not a natural disease, but rather an iatrogenic disease, GvHD can occur at any age, depending on when a patient underwent a bone marrow transplant. | ||
Revision as of 03:42, 4 July 2017
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
- The incidence of GvHD is estimated to be 9.5x10-7 per 100,000 cases. There are approximately 5500 total cases annually.[1]
- Patients of all age groups may develop GvHD, but it occurs more commonly in older persons who receive stem cells from female donors.
- GvHD affects men more commonly than women.
- There is no racial predilection to GvHD.
- The incidence of GvHD is not directly correlated with age, as the disease is an iatrogenic condition that occurs after a transplant, rather than a natural disease.
Epidemiology and Demographics
Prevalence
- In developing countries, the prevalence of GvHD has not been studied, as bone marrow transplants are only performed in highly specialized centers.
- There is no data on the number of persons living with GvHD.
Incidence
- Worldwide, the incidence of GvHD ranges from a low of 8x10^-7 per 100,000 persons to a high of 1.14x10-6 per 100,000 persons with an average incidence of 9.5x10-7 per 100,000 persons.[1] The reason for the low incidence worldwide is that the disease can only occur after a bone marrow transplantation, and bone marrow transplantations occur only in highly specialized centers.
- In developing countries, the incidence of GvHD has not been studied, as bone marrow transplants are only performed in highly specialized centers.
- In 2003, the incidence of GvHD was estimated to range from 4795 to 6850 total cases worldwide.[1]
Case Fatality Rate
- The annual case fatality rate of GvHD is approximately 50%.
Age
- GvHD is more likely to occur in persons of older age. However, given that this is not a natural disease, but rather an iatrogenic disease, GvHD can occur at any age, depending on when a patient underwent a bone marrow transplant.
Gender
- Males are more commonly affected with GvHD than females. The male to female ratio is approximately 1.4:1.[2]
Race
- The prevalence of GvHD does not vary by race.
References
- ↑ 1.0 1.1 1.2 Jacobsohn DA, Vogelsang GB (2007). "Acute graft versus host disease". Orphanet J Rare Dis. 2: 35. doi:10.1186/1750-1172-2-35. PMC 2018687. PMID 17784964.
- ↑ Kim HT, Zhang MJ, Woolfrey AE, St Martin A, Chen J, Saber W; et al. (2016). "Donor and recipient sex in allogeneic stem cell transplantation: what really matters". Haematologica. 101 (10): 1260–1266. doi:10.3324/haematol.2016.147645. PMC 5046656. PMID 27354023.