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|style="background: #F5F5F5; padding: 5px;" |Treponema Pallidum | |style="background: #F5F5F5; padding: 5px;" |Treponema Pallidum | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" |16th to 28th week | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" |Based on the stage of Syphilis infection | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | |||
*Non-immune Hydrops | |||
*Maculopapular or Vesicobullous rash on the palms and soles | |||
*Interstitial Keratitis | |||
*Rhinitis | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Early congenital syphilis | |||
*Late congnenital syphilis | |||
*Stigmata | |||
|style="background: #F5F5F5; padding: 5px;" | | |||
*Detection of IgM aganist T.pallidum in blood collected in chordocentesis | |||
*Amniotic fluid PCR for T. pallidum DNA | |||
*Antenatal Ultrasound | |||
|style="background: #F5F5F5; padding: 5px;" | | |||
*Aqueous crystalline penicillin G 100,000-150,000 U/kg/day, administered as 50,000 U/kg/dose IV q12h during the first 7 days of life and q8h thereafter for a total of 10 days | |||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Toxoplasmosis | |style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Toxoplasmosis | ||
|style="background: #F5F5F5; padding: 5px;" |Toxoplama gondii | |style="background: #F5F5F5; padding: 5px;" |Toxoplama gondii | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |||
|style="background: #F5F5F5; padding: 5px;" |Third Trimester | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Majority : Asymptomatic | |||
*Few patients can have flu like symptoms | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | |||
*Chorioretinitis | |||
*Microcephaly | |||
*Intracranial calcification | |||
*Spasticities and Paresis | |||
*Sensorineural deafness | |||
|style="background: #F5F5F5; padding: 5px;" | None | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Amniotic fluid PCR for T.gondii DNA | |||
*Detection of parasite in Amniotic fluid | |||
*Serology | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Infected mothers without fetal infection : Spiramycin | |||
*Infected mothers with established fetal infection : Pyrimethamine, sulfadiazine, and folinic acid | |||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Varicella Syndrome | |style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Varicella Syndrome | ||
|style="background: #F5F5F5; padding: 5px;" |Varicella Zoster virus | |style="background: #F5F5F5; padding: 5px;" |Varicella Zoster virus | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |||
|style="background: #F5F5F5; padding: 5px;" |13 to 20th week | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Vesicular skin rash | |||
*Fever | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Cicatrical skin lesions | |||
*Limb hypoplasia | |||
*Microcephaly | |||
*Autonomic instability | |||
*Chorioretinitis | |||
*Microphalmia and anisocoria | |||
|style="background: #F5F5F5; padding: 5px;" |None | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Antenatal Ultrasound | |||
*Fetal MRI | |||
*Amniotic fluid PCR for VZV DNA | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Termination of pregnancy with severe defects | |||
*No definitive treatment | |||
*Preconceptional vaccination | |||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital CMV | |style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital CMV | ||
|style="background: #F5F5F5; padding: 5px;" |CMV Virus | |style="background: #F5F5F5; padding: 5px;" |CMV Virus | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |||
|style="background: #F5F5F5; padding: 5px;" |trimester | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Fever | |||
*Cervical lymphadenopathy | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*[[Small for gestational age|SGA]] | |||
*[[Microcephaly]] | |||
*[[Sensorineural hearing loss]] | |||
*[[Cataracts]] | |||
*[[Petechiae]] and [[purpura]] | |||
*[[Jaundice]] | |||
*Poor sucking when feeding | |||
*[[Hypotonia]] | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Symptomatic | |||
*Asymptomatic | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Antenatal Ultrasound | |||
*Amniotic Fluid PCR for CMV DNA | |||
*CT brain | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*IV Ganciclovir | |||
*Oral Valganciclovir | |||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Rubella Syndrome | |style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Rubella Syndrome | ||
|style="background: #F5F5F5; padding: 5px;" |Rubella | |style="background: #F5F5F5; padding: 5px;" |Rubella | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |||
|style="background: #F5F5F5; padding: 5px;" |8 to 10th week | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Asymptomatic | |||
*Maculopapular rash starting on the face and spreads caudally | |||
*Polyarthalgia | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | |||
*VSD and PDA | |||
*Cataracts, glacoma, retinopathy | |||
*Sensorineural hearing loss | |||
*Microcephaly | |||
*Encephalitis | |||
|style="background: #F5F5F5; padding: 5px;" |None | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
* Direct isolation of the [[virus]] | |||
* [[Viral]] [[nucleic acid]] quantification | |||
* Detection of [[IgM]]/ [[IgA]] [[antibodies]] in [[fetal]] [[blood]] | |||
*Serological Testing | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Termination of pregnancy: If infection diagnosed before 18weeks of pregnancy | |||
*No definitive Treatment | |||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Neonatal Herpes Simplex | |style="background: #DCDCDC; padding: 5px; text-align: center;" |Neonatal Herpes Simplex | ||
|style="background: #F5F5F5; padding: 5px;" |HSV-1 and HSV-2 | |style="background: #F5F5F5; padding: 5px;" |HSV-1 and HSV-2 | ||
|style="background: #F5F5F5; padding: 5px;" |Direct Contact | |||
|style="background: #F5F5F5; padding: 5px;" |At term | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Genital or Orolabial herpes | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Vesicular skin lesions | |||
*Oral Ulcers | |||
*Chorioretinitis and conjunctival erythema | |||
*Encephalitis | |||
*DIC | |||
*Pneumonitis | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Skin, eye, mouth disease (SEM) | |||
*CNS Disease | |||
*Disseminated Disease | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Surface Cultures | |||
*CNS fluid analysis | |||
*Elevated Alanine Transaminase | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*SEM : IV Acyclovir for 10 days | |||
*Disseminated and CNS disease: IV Acyclovir for 14 to 21 days | |||
|} | |} |
Revision as of 19:17, 3 March 2017
Diseases | Causative Organism | Transmission | Timing of Infection | Clinical Symptoms in the Mother | Clinical Manifestations in the newborn | Classification | Diagnosis | Treatment |
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Congenital Syphilis | Treponema Pallidum | Vertical | 16th to 28th week | Based on the stage of Syphilis infection |
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Congenital Toxoplasmosis | Toxoplama gondii | Vertical | Third Trimester |
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None |
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Congenital Varicella Syndrome | Varicella Zoster virus | Vertical | 13 to 20th week |
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None |
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Congenital CMV | CMV Virus | Vertical | trimester |
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Congenital Rubella Syndrome | Rubella | Vertical | 8 to 10th week |
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None |
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Neonatal Herpes Simplex | HSV-1 and HSV-2 | Direct Contact | At term |
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