Sandbox: Reddy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]

Synonyms and keywords: Fetal varicella syndrome, Congenital varicella-zoster syndrome, Varicella embryo-fetopathy, Varicella embryopathy, Varicella fetopathy, Fetal varicella-zoster syndrome

Historical Perspective

• In 1935, the first case resembling neonatal HSV, was described with the presence of intranuclear inclusion bodies in a premature infant in the liver and the adrenals.

Pathophysiology

Pathogenesis

Transmission of infection

• Transmission from active genital herpes lesions, accounts for majority of neonatal herpes cases.
• Intrauterine infection accounts for 5% of cases with neonatal herpes simplex.
• Postnatal trasmission by contact with HSV shed from infected patients. It accounts for 10% of the cases.