Kaposi's sarcoma staging: Difference between revisions

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* The staging of AIDS-associated Kaposi's sarcoma is based on the  AIDS Clinical Trials Group (ACTG) staging system. According to the ACTG staging system, there are 2 groups of AIDS-associated Kaposi's sarcoma based on the tumor size, immune status, and the presence of any systemic illness.
* The staging of AIDS-associated Kaposi's sarcoma is based on the  AIDS Clinical Trials Group (ACTG) staging system. According to the ACTG staging system, there are 2 groups of AIDS-associated Kaposi's sarcoma based on the tumor size, immune status, and the presence of any systemic illness.


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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Factors}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Good Risk (Stage 0)}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Poor Risk (Stage 1)}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |
Tumor (T)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Confined to skin and lymph nodes
* Minimal oral lesions (non-nodular kaposi's sarcoma confined to the palate)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Tumor-associated edema or ulceration
* Extensive oral lesions present
* Gastrointestinal lesions present
* Kaposi sarcoma present in other non-nodal viscera
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center |
Immune system (I)
| style="padding: 5px 5px; background: #F5F5F5;" |
* CD4 cell count ≥ 200/µL
| style="padding: 5px 5px; background: #F5F5F5;" |
* CD4 cell count < 200/µL
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center |
Systemic illness (S)
| style="padding: 5px 5px; background: #F5F5F5;" |
* No history of opportunistic infection or thrush
* No “B” symptoms
* Karnofsky performance status score ≥ 70
| style="padding: 5px 5px; background: #F5F5F5;" |
* Positive history of opportunistic infection or thrush
* “B” symptoms present
* Karnofsky performance status score < 70
|}
==References==
==References==



Revision as of 15:53, 20 January 2016

Kaposi's sarcoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

There is no established system for the staging of Kaposi's sarcoma among immune competent patients. However, the staging of AIDS-associated Kaposi's sarcoma is based on the AIDS Clinical Trials Group (ACTG) staging system. According to the ACTG staging system, there are 2 groups of AIDS-associated Kaposi's sarcoma based on the tumor size, immune status, and the presence of any systemic illness.[1][2][3][4][5]

Staging

  • There is no established system for the staging of Kaposi's sarcoma among immune competent patients.
  • The staging of AIDS-associated Kaposi's sarcoma is based on the AIDS Clinical Trials Group (ACTG) staging system. According to the ACTG staging system, there are 2 groups of AIDS-associated Kaposi's sarcoma based on the tumor size, immune status, and the presence of any systemic illness.
Factors Good Risk (Stage 0) Poor Risk (Stage 1)

Tumor (T)

  • Confined to skin and lymph nodes
  • Minimal oral lesions (non-nodular kaposi's sarcoma confined to the palate)
  • Tumor-associated edema or ulceration
  • Extensive oral lesions present
  • Gastrointestinal lesions present
  • Kaposi sarcoma present in other non-nodal viscera

Immune system (I)

  • CD4 cell count ≥ 200/µL
  • CD4 cell count < 200/µL

Systemic illness (S)

  • No history of opportunistic infection or thrush
  • No “B” symptoms
  • Karnofsky performance status score ≥ 70
  • Positive history of opportunistic infection or thrush
  • “B” symptoms present
  • Karnofsky performance status score < 70

References

  1. Kaposi Sarcoma Treatment–for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/soft-tissue-sarcoma/hp/kaposi-treatment-pdq#section/_15 Accessed on January, 20 2015
  2. Krown SE, Metroka C, Wernz JC (1989). "Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. AIDS Clinical Trials Group Oncology Committee". J Clin Oncol. 7 (9): 1201–7. PMID 2671281.
  3. Krown SE, Testa MA, Huang J (1997). "AIDS-related Kaposi's sarcoma: prospective validation of the AIDS Clinical Trials Group staging classification. AIDS Clinical Trials Group Oncology Committee". J Clin Oncol. 15 (9): 3085–92. PMID 9294471.
  4. Sarcoma- Kaposi Guide. Cancer.Net (2015) http://www.cancer.net/cancer-types/sarcoma-kaposi/risk-factors-and-prevention Accessed on January, 20 2015
  5. How is Kaposi sarcoma staged? American Cancer Association (2015) http://www.cancer.org/cancer/kaposisarcoma/detailedguide/kaposi-sarcoma-staging Accessed on January, 20 2016

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