Hereditary nonpolyposis colorectal cancer epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.<ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> | The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.<ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> The average age of diagnosis is often less than 45 years old. HNPCC affects men and women equally. <ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
In the United States, about 160,000 new cases of [[colorectal cancer]] are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of [[colorectal cancer]]. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome. <ref> Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015 </ref> | |||
In the United States, about 160,000 new cases of [[colorectal cancer]] are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of [[colorectal cancer]]. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome.<ref> Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015 </ref> In ethnically-diverse patients, the detection rate for MMR mutations is significantly lower, compared to white patients.<ref>Monteiro santos EM, Valentin MD, Carneiro F, et al. Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. BMC Cancer. 2012;12:64.</ref> | |||
===Prevalence=== | ===Prevalence=== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1] The average age of diagnosis is often less than 45 years old. HNPCC affects men and women equally. [1]
Epidemiology and Demographics
In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of colorectal cancer. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome.[2] In ethnically-diverse patients, the detection rate for MMR mutations is significantly lower, compared to white patients.[3]
Prevalence
- The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1]
Age
- Early age onset (often <45)
Gender
- HNPCC affects men and women equally. However, in some particular genetic mutations such as MLH1 males have significantly higher risk than females at all ages.[1]
References
- ↑ 1.0 1.1 1.2 1.3 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.
- ↑ Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015
- ↑ Monteiro santos EM, Valentin MD, Carneiro F, et al. Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. BMC Cancer. 2012;12:64.