Ivermectin (oral): Difference between revisions

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__NOTOC__
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{{Ivermectin}}
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==Overview==
* Content


Ivermectin (22,23-dihydroavermectin B<sub>1a</sub> + 22,23-dihydroavermectin B<sub>1b</sub>) is a broad-spectrum anti-[[parasite]] medication, traditionally used against[[worm]]s (except [[cestoda|tapeworms]]), but more recently found to be effective against most [[mite]]s and some [[louse|lice]] too. It is sold under [[brand names]] Stromectol® in the United States,  Mectizan® in Canada by [[Merck & Co.|Merck]] and Ivexterm® in Mexico by [[Valeant Pharmaceuticals International]].
<!--Adult Indications and Dosage-->


==Category==
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====


Antiparasitic
* Dosing Information


==US Brand Names==
:* Dosage


STROMECTOL<sup>®</sup>
=====Condition2=====


==FDA Package Insert==
* Dosing Information


'''  [[Ivermectin description|Description]]'''
:* Dosage
'''| [[Ivermectin clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Ivermectin microbiology|Microbiology]]'''
'''| [[Ivermectin indications and usage|Indications and Usage]]'''
'''| [[Ivermectin contraindications|Contraindications]]'''
'''| [[Ivermectin warnings and precautions|Warnings and Precautions]]'''
'''| [[Ivermectin adverse reactions|Adverse Reactions]]'''
'''| [[Ivermectin drug interactions|Drug Interactions]]'''
'''| [[Ivermectin overdosage|Overdosage]]'''
'''| [[Ivermectin clinical studies|Clinical Studies]]'''
'''| [[Ivermectin dosage and administration|Dosage and Administration]]'''
'''| [[Ivermectin how supplied|How Supplied]]'''
'''| [[Ivermectin labels and packages|Labels and Packages]]'''


==Mechanism of Action==
=====Condition3=====


Ivermectin and the related molecule '''[[avermectin]]''' (an [[insecticide]] most frequently used in home-use ant baits) are derived  from the [[bacterium]] ''[[Streptomyces avermitilis]]''. Ivermectin kills by interfering with [[nervous system]] and [[muscle]] function, in particular by enhancing inhibitory [[neurotransmission]]. The drug binds and activates glutamate-gated chloride channels (GluCls) present in [[neuron]]s and [[myocyte]]s (Cully et al., 1994; Cully et al., 1997, Dent et al., 1997), resulting in neuro-muscular paralysis and death. Mutations in GluCls that reduce their response to ivermectin confer ivermectin resistance (Dent et al, 2000, Kane et al., 2000). Although similar in structure to vertebrate ionotropic glycine receptors, glutamate-gated chloride channels are specific to invertebrates (Dent, 2006). The absence of glutamate-gated chloride channels from mammals appears to account in part for the specificity of ivermectin for invertebrate parasites and its relative lack of side effects in mammalian hosts (Lerchner et al., 2007). Invertebrate GABA receptors have been implicated in ivermectin sensitivity although their importance is still unclear (Ludmerer et al., 2002, Blackhall 2003). The principal peripheral neurotransmitter receptor in mammals, the nicotinic acetylcholine receptor, is relatively unaffected by the drug (MSD, 1988), which contributes to its safety.
* Dosing Information


==References==
:* Dosage
{{Reflist|2}}


[[Category:Antibiotics]]
=====Condition4=====
[[Category:Wikinfect]]
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
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* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
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* Dosing Information
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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* Dosing Information
 
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* Developed by:
 
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* Strength of Evidence:
 
* Dosing Information
 
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* Dosing Information
 
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=====Body as a Whole=====
 
 
 
 
=====Cardiovascular=====
 
 
 
 
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=====Endocrine=====
 
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
 
=====Metabolic and Nutritional=====
 
 
 
 
=====Musculoskeletal=====
 
 
 
 
=====Neurologic=====
 
 
 
 
=====Respiratory=====
 
 
 
 
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=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
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<!--Administration and Monitoring-->
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* Intravenous
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* Description
 
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====Signs and Symptoms====
 
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====Management====
 
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===Chronic Overdose===
 
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<!--Precautions with Alcohol-->
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[[Category:Drug]]

Revision as of 02:19, 19 December 2014

Ivermectin (oral)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Ivermectin (oral) is a that is FDA approved for the of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Ivermectin (oral) in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Ivermectin (oral) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Ivermectin (oral) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Ivermectin (oral) in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Ivermectin (oral) in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Ivermectin (oral) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Ivermectin (oral) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Ivermectin (oral) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Ivermectin (oral) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Ivermectin (oral) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Ivermectin (oral) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Ivermectin (oral) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Ivermectin (oral) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Ivermectin (oral) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Ivermectin (oral) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Ivermectin (oral) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Ivermectin (oral) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Ivermectin (oral) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Ivermectin (oral) in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Ivermectin (oral) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Ivermectin (oral) in the drug label.

Pharmacology

There is limited information regarding Ivermectin (oral) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Ivermectin (oral)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Ivermectin (oral) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Ivermectin (oral) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Ivermectin (oral) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Ivermectin (oral) in the drug label.

How Supplied

Storage

There is limited information regarding Ivermectin (oral) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Ivermectin (oral) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Ivermectin (oral) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Ivermectin (oral) in the drug label.

Precautions with Alcohol

  • Alcohol-Ivermectin (oral) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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