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{{Drugbox
__NOTOC__
| Verifiedfields = changed
{{Interferon alfacon-1}}
| verifiedrevid = 458271293
'''''For patient information, click <u>[[Interferon alfacon-1 (patient information)|here]]'''''</u>.
| IUPAC_name        =
| image            =
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<!--Clinical data-->
{{CMG}}; {{AE}} {{SS}}
| tradename        = 
| Drugs.com        =
| MedlinePlus      =
| licence_EU        = <!-- EMA requires brand name -->
| licence_US        = <!-- FDA may use generic name -->
| DailyMedID        = <!-- preference to licence_US -->
| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      = C
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = Rx-only
| legal_status      =
| dependency_liability =
| routes_of_administration = Parenteral
 
<!--Pharmacokinetic data-->
| bioavailability  =
| protein_bound    =
| metabolism        =
| elimination_half-life =
| excretion        =
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number        = 118390-30-0
| CAS_supplemental  =
| ATCvet            =
| ATC_prefix        = L03
| ATC_suffix        = AB09
| ATC_supplemental  =
| PubChem          =
| PubChemSubstance  =
| IUPHAR_ligand    =
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank          = DB00069
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = NA
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII              =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG              =
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI            =
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL            =
 
<!--Chemical data-->
| C=860 | H=1353 | N=227 | O=255 | S=9
| molecular_weight  = 19343 g/mol
| smiles            =
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI          =
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey      =
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| density          =
}}


==Overview==
'''Interferon alfacon-1''' is a recombinant synthetic [[Interferon type I|type I interferon]] used for the treatment of [[hairy cell leukemia]], [[melanoma|malignant melanoma]] and [[AIDS]]-related [[Kaposi's sarcoma]].<ref name="DrugBank">{{DrugBank|DB00069}}</ref>
'''Interferon alfacon-1''' is a recombinant synthetic [[Interferon type I|type I interferon]] used for the treatment of [[hairy cell leukemia]], [[melanoma|malignant melanoma]] and [[AIDS]]-related [[Kaposi's sarcoma]].<ref name="DrugBank">{{DrugBank|DB00069}}</ref>


== References ==
==Category==
<references/>
Antiviral
 
==US Brand Names==
{{Immunostimulants}}
INFERGEN<sup>®</sup>
==FDA Package Insert==


[[Category:Immunostimulants]]
'''  [[Interferon alfacon-1 description|Description]]'''
[[Category:Antivirals]]
'''| [[Interferon alfacon-1 clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Interferon alfacon-1 microbiology|Microbiology]]'''
'''| [[Interferon alfacon-1 indications and usage|Indications and Usage]]'''
'''| [[Interferon alfacon-1 contraindications|Contraindications]]'''
'''| [[Interferon alfacon-1 warnings and precautions|Warnings and Precautions]]'''
'''| [[Interferon alfacon-1 adverse reactions|Adverse Reactions]]'''
'''| [[Interferon alfacon-1 drug interactions|Drug Interactions]]'''
'''| [[Interferon alfacon-1 overdosage|Overdosage]]'''
'''| [[Interferon alfacon-1 clinical studies|Clinical Studies]]'''
'''| [[Interferon alfacon-1 dosage and administration|Dosage and Administration]]'''
'''| [[Interferon alfacon-1 how supplied|How Supplied]]'''
'''| [[Interferon alfacon-1 labels and packages|Labels and Packages]]'''


==Mechanism of Action==
Interferon alfacon-1 is a recombinant hybrid protein based on the consensus amino acid sequence of naturally occurring human type-I interferon alphas. Type-I interferons are a family of small protein molecules with molecular weights of 15,000 to 21,000 daltons that are produced and secreted by cells in response to viral infections or to various synthetic and biological inducers. Interferons do not act directly on the virus but bind to the interferon cell-surface receptor leading to the production of several interferon-stimulated gene products. Interferons induce pleiotropic biologic responses which include antiviral, antiproliferative, and immunomodulatory effects, regulation of cell surface major histocompatibility antigen (HLA class I and class II) expression and regulation of cytokine expression.
==References==
{{Reflist|2}}


{{antineoplastic-drug-stub}}
[[Category:Antibiotics]]
[[Category:Wikinfect]]

Revision as of 15:48, 8 January 2014

Interferon alfacon-1
INFERGEN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

For patient information, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Overview

Interferon alfacon-1 is a recombinant synthetic type I interferon used for the treatment of hairy cell leukemia, malignant melanoma and AIDS-related Kaposi's sarcoma.[1]

Category

Antiviral

US Brand Names

INFERGEN®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

Interferon alfacon-1 is a recombinant hybrid protein based on the consensus amino acid sequence of naturally occurring human type-I interferon alphas. Type-I interferons are a family of small protein molecules with molecular weights of 15,000 to 21,000 daltons that are produced and secreted by cells in response to viral infections or to various synthetic and biological inducers. Interferons do not act directly on the virus but bind to the interferon cell-surface receptor leading to the production of several interferon-stimulated gene products. Interferons induce pleiotropic biologic responses which include antiviral, antiproliferative, and immunomodulatory effects, regulation of cell surface major histocompatibility antigen (HLA class I and class II) expression and regulation of cytokine expression.

References

  1. ↑ Template:DrugBank
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