Sandbox: GDS: Difference between revisions
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==Mc Cune Albright syndrome== | |||
===Clinical Features=== | |||
*Precocious Puberty | |||
*Fibrous Dysplasia of Long Bones | |||
*Cafe au lait spots( irregular macules confined to one side of the body) | |||
===Explanation=== | |||
McCune Albright Syndrome occurs due to mutation in the GNAS gene which leads to constant G- protein activation which leads to overproduction of pituitary hormones. Thus in addition to precocious puberty ( GnRH independent increase in LH and FSH), MAS can cause an increase in TSH and GH and ACTH leading to Cushing syndrome. | |||
==BVC== | |||
====ABC==== | ====ABC==== | ||
Insulinoma reference example<ref name="pmid18703061">{{cite journal |vauthors=Metz DC, Jensen RT |title=Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors |journal=Gastroenterology |volume=135 |issue=5 |pages=1469–92 |date=November 2008 |pmid=18703061 |pmc=2612755 |doi=10.1053/j.gastro.2008.05.047 |url=}}</ref> | Insulinoma reference example<ref name="pmid18703061">{{cite journal |vauthors=Metz DC, Jensen RT |title=Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors |journal=Gastroenterology |volume=135 |issue=5 |pages=1469–92 |date=November 2008 |pmid=18703061 |pmc=2612755 |doi=10.1053/j.gastro.2008.05.047 |url=}}</ref> | ||
==Reference== | ==Reference== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:04, 6 June 2020
My Practice Page
Mc Cune Albright syndrome
Clinical Features
- Precocious Puberty
- Fibrous Dysplasia of Long Bones
- Cafe au lait spots( irregular macules confined to one side of the body)
Explanation
McCune Albright Syndrome occurs due to mutation in the GNAS gene which leads to constant G- protein activation which leads to overproduction of pituitary hormones. Thus in addition to precocious puberty ( GnRH independent increase in LH and FSH), MAS can cause an increase in TSH and GH and ACTH leading to Cushing syndrome.
BVC
ABC
Insulinoma reference example[1]
Reference
- ↑ Metz DC, Jensen RT (November 2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.