Glanzmann's thrombasthenia history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage | Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage:<ref name="pmid18186523">{{cite journal |vauthors=Bakdash S, Lyons JM, Bastacky SI, Pezzone MA, McGee JB, Schoen RE, Regueiro M, Lee KK, Bontempo FA |title=Management of persistent gastric bleeding in a patient with Glanzmann's thrombasthenia |journal=Am. J. Hematol. |volume=83 |issue=5 |pages=411–5 |date=May 2008 |pmid=18186523 |doi=10.1002/ajh.21122 |url=}}</ref> | ||
It may include any of the following manifestation: | It may include any of the following manifestation:<ref name="pmid18186523">{{cite journal |vauthors=Bakdash S, Lyons JM, Bastacky SI, Pezzone MA, McGee JB, Schoen RE, Regueiro M, Lee KK, Bontempo FA |title=Management of persistent gastric bleeding in a patient with Glanzmann's thrombasthenia |journal=Am. J. Hematol. |volume=83 |issue=5 |pages=411–5 |date=May 2008 |pmid=18186523 |doi=10.1002/ajh.21122 |url=}}</ref><ref name="pmid2180491">{{cite journal |vauthors=George JN, Caen JP, Nurden AT |title=Glanzmann's thrombasthenia: the spectrum of clinical disease |journal=Blood |volume=75 |issue=7 |pages=1383–95 |date=April 1990 |pmid=2180491 |doi= |url=}}</ref><ref name="pmid15389911">{{cite journal |vauthors=Toogeh G, Sharifian R, Lak M, Safaee R, Artoni A, Peyvandi F |title=Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran |journal=Am. J. Hematol. |volume=77 |issue=2 |pages=198–9 |date=October 2004 |pmid=15389911 |doi=10.1002/ajh.20159 |url=}}</ref><ref name="pmid21917754">{{cite journal |vauthors=Nurden AT, Fiore M, Nurden P, Pillois X |title=Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models |journal=Blood |volume=118 |issue=23 |pages=5996–6005 |date=December 2011 |pmid=21917754 |doi=10.1182/blood-2011-07-365635 |url=}}</ref> | ||
* Easily bruising (76.6%) | * Easily bruising (76.6%) |
Revision as of 17:03, 10 December 2018
Glanzmann's thrombasthenia |
Differentiating Glanzmann's thrombasthenia from other Diseases |
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Case Studies |
Glanzmann's thrombasthenia history and symptoms On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
History
History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia.
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. [1] The severity of the presenting symptoms has no known relation to the affected gene. However mutations in the ITGB3 gene manifest bleeding more than the other gene .[2]
Symptoms
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage:[3]
It may include any of the following manifestation:[3][4][5][6]
- Easily bruising (76.6%)
- Nosebleeds that do not stop easily (62.5%)
- Bleeding gums (56.4%)
- Prolonged bleeding with minor injuries (47.2%)
- Heavy menstrual bleeding
- postpartum bleeding
- gastrointestinal bleeding
- Heavy bleeding during and after surgery
- bleeding into joints (rare) [7]
References
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.
- ↑ Fiore M, Nurden AT, Nurden P, Seligsohn U (2012). "Clinical utility gene card for: Glanzmann thrombasthenia". Eur J Hum Genet. 20 (10). doi:10.1038/ejhg.2012.151. PMC 3449071. PMID 22781097.
- ↑ 3.0 3.1 Bakdash S, Lyons JM, Bastacky SI, Pezzone MA, McGee JB, Schoen RE, Regueiro M, Lee KK, Bontempo FA (May 2008). "Management of persistent gastric bleeding in a patient with Glanzmann's thrombasthenia". Am. J. Hematol. 83 (5): 411–5. doi:10.1002/ajh.21122. PMID 18186523.
- ↑ George JN, Caen JP, Nurden AT (April 1990). "Glanzmann's thrombasthenia: the spectrum of clinical disease". Blood. 75 (7): 1383–95. PMID 2180491.
- ↑ Toogeh G, Sharifian R, Lak M, Safaee R, Artoni A, Peyvandi F (October 2004). "Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran". Am. J. Hematol. 77 (2): 198–9. doi:10.1002/ajh.20159. PMID 15389911.
- ↑ Nurden AT, Fiore M, Nurden P, Pillois X (December 2011). "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models". Blood. 118 (23): 5996–6005. doi:10.1182/blood-2011-07-365635. PMID 21917754.
- ↑ Iqbal I, Farhan S, Ahmed N (2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check
|doi=
value (help). PMID 27539755.