Bleeding diathesis: Difference between revisions

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== Differential Diagnosis ==
== Differential Diagnosis ==
=== Disorders of the Coagulation Cascade ===
# Inherited Bleeding Disorders  Examples: Hemophilia A (Factor VIII deficiency), Hemophilia B (Factor IX deficiency), Von Willebrand disease and congenital fibrinogen deficiency. Studies from the Kingdom have shown that the distribution of hereditary bleeding disorders (HBD) resemble what has been established in western countries, with the exception of an increase of platelet disorders mostly due to the increased rate of consanguinity in the Kingdom.27–29 The most common HBD in the Kingdom is hemophilia A, followed by VWD, then hemophilia B followed by qualitative platelet disorders most commonly Glanzmanns thrombasthenia.27–29
# Acquired Bleeding Disorders  These include liver disease, vitamin K deficiency, DIC and anticoagulant therapy.3
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Revision as of 14:49, 24 August 2018


Bleeding diathesis main page

Overview

Classification

Differential Diagnosis

Platelet disorders
Immune Thrombocytopenic Purpura
Thrombotic Thrombocytopenic Purpura
Hemolytic Uremic Syndrome
Thrombocytosis
Von Willebrand Disease
Coagulation disorders
Fibrinogen deficiency
Prothrombin deficiency
Factor V deficiency
Factor VII deficiency
Factor VIII deficiency
Factor IX deficiency
Factor X deficiency
Factor XI deficiency
Factor XII deficiency
High-molecular-weight kininogen deficiency
Prekallikrein deficiency
Factor XIII deficiency
Hemophilia
Rare diseases
Disseminated Intravascular Coagulation
Vitamin K Deficiency

Different types of Von-Willebrand diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mehrian Jafarizade, M.D [2]

Overview

Classification

Differential Diagnosis

Disorders of the Coagulation Cascade

  1. Inherited Bleeding Disorders Examples: Hemophilia A (Factor VIII deficiency), Hemophilia B (Factor IX deficiency), Von Willebrand disease and congenital fibrinogen deficiency. Studies from the Kingdom have shown that the distribution of hereditary bleeding disorders (HBD) resemble what has been established in western countries, with the exception of an increase of platelet disorders mostly due to the increased rate of consanguinity in the Kingdom.27–29 The most common HBD in the Kingdom is hemophilia A, followed by VWD, then hemophilia B followed by qualitative platelet disorders most commonly Glanzmanns thrombasthenia.27–29
  2. Acquired Bleeding Disorders These include liver disease, vitamin K deficiency, DIC and anticoagulant therapy.3
Category Sub-category Diseases History Clinical manifestation Laboratory testing
Petechiae Ecchymoses Menorrhagia Hematomas Hemarthrosis platelet count Bleeding time (BT) Prothrombin time (PT) Platelet count activated partial thromboplastin time (aPTT) Thrombin time (TT)
Platelet disorders Thrombocytopenia Infection-Induced Thrombocytopenia
Medications-Induced Thrombocytopenia
Heparin-Induced Thrombocytopenia
Immune Thrombocytopenic Purpura (ITP)
Inherited Thrombocytopenia
Thrombotic Thrombocytopenic Purpura (TTP)
Hemolytic Uremic Syndrome
Thromobcytosis Thrombocytosis in response to acute or chronic inflammation has not been associated with an increased thrombotic risk. In fact, patients with markedly elevated platelet counts (>1.5 million), usually seen in the setting of a myeloproliferative disorder, have an increased risk of bleeding. This appears to be due, at least in part, to acquired von Willebrand disease (VWD) due to platelet-VWF adhesion and removal.
Qualitative Disorders of Platelet Function Inherited Disorders of Platelet Function
Acquired Disorders of Platelet Function
Von Willebrand Disease
Vessel wall disorders Metabolic and Inflammatory Disorders
Inherited Disorders of the Vessel Wall
Coagulation disorders Fibrinogen deficiency
Prothrombin deficiency
Factor V deficiency
Factor VII deficiency
Factor VIII deficiency
Factor IX deficiency
Factor X deficiency
Factor XI deficiency
Factor XII deficiency
HK deficiency
Prekallikrein deficiency
Factor XIII deficiency
Hemophilia Type A deficiency Unaffected Unaffected Unaffected Prolonged
Type B deficiency
Type C deficiency
Rare diseases Disseminated Intravascular Coagulation
Vitamin K Deficiency
Coagulation Disorders Associated with Liver Failure
Acquired Inhibitors of Coagulation Factors