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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2''' also known as '''membrane-associated guanylate kinase inverted 2''' (MAGI-2) and '''atrophin-1-interacting protein 1''' (AIP-1) is an [[enzyme]] that in humans is encoded by the ''MAGI2'' [[gene]].<ref name="pmid10681527">{{cite journal |vauthors=Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H | title = Identification and characterization of a PDZ protein that interacts with activin type II receptors | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5485–92 |date=Mar 2000 | pmid = 10681527 | pmc =  | doi =10.1074/jbc.275.8.5485  }}</ref><ref name="pmid9734811">{{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc = | doi =10.1093/dnares/5.3.169  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9863| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAGI2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uep.
| PDB = {{PDB2|1uep}}, {{PDB2|1ueq}}, {{PDB2|1uew}}, {{PDB2|1ujv}}, {{PDB2|1wfv}}
| Name = Membrane associated guanylate kinase, WW and PDZ domain containing 2
| HGNCid = 18957
| Symbol = MAGI2
| AltSymbols =; AIP1; ACVRIP1; ARIP1; MAGI-2
| OMIM = 606382
| ECnumber = 
| Homologene = 8189
| MGIid = 1354953
| GeneAtlas_image1 = PBB_GE_MAGI2_209737_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAGI2_207702_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019902 |text = phosphatase binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9863
    | Hs_Ensembl = ENSG00000187391
    | Hs_RefseqProtein = NP_036433
    | Hs_RefseqmRNA = NM_012301
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 77486568
    | Hs_GenLoc_end = 78920572
    | Hs_Uniprot = Q86UL8
    | Mm_EntrezGene = 50791
    | Mm_Ensembl = ENSMUSG00000040003
    | Mm_RefseqmRNA = XM_001000863
    | Mm_RefseqProtein = XP_001000863
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 18739113
    | Mm_GenLoc_end = 20173176
    | Mm_Uniprot = Q9WVQ1
  }}
}}
'''Membrane associated guanylate kinase, WW and PDZ domain containing 2''', also known as '''MAGI2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9863| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene interacts with [[ATN1|atrophin-1]]. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for [[dentatorubral-pallidoluysian atrophy]]. This encoded protein is characterized by two [[WW domain]]s, a [[guanylate kinase]]-like domain, and multiple [[PDZ domain]]s. It has structural similarity to the membrane-associated guanylate kinase homologue ([[CASK|MAGUK]]) family.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.<ref name="entrez">{{cite web | title = Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9863| accessdate = }}</ref>
MAGI2 has been shown to [[Protein-protein interaction|interact]] with [[ATN1]]<ref name=pmid9647693>{{cite journal |last=Wood |first=J D |authorlink= |author2=Yuan J |author3=Margolis R L |author4=Colomer V |author5=Duan K |author6=Kushi J |author7=Kaminsky Z |author8=Kleiderlein J J |author9=Sharp A H |author10=Ross C A  |date=Jun 1998 |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins |journal=Mol. Cell. Neurosci. |volume=11 |issue=3 |pages=149–60 |publisher= |location = UNITED STATES| issn = 1044-7431| pmid = 9647693 |doi = 10.1006/mcne.1998.0677 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PTEN (gene)]].
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Wood JD, Yuan J, Margolis RL, etal |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
| citations =
*{{cite journal   |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=Wood JD, Yuan J, Margolis RL, ''et al.'' |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149-60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
*{{cite journal   |vauthors=Ide N, Hata Y, Deguchi M, etal |title=Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 456–61 |year= 1999 |pmid= 10080919 |doi= 10.1006/bbrc.1999.0364 }}
*{{cite journal | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal   |vauthors=Wu X, Hepner K, Castelino-Prabhu S, etal |title=Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4233–8 |year= 2000 |pmid= 10760291 |doi=10.1073/pnas.97.8.4233  | pmc=18208 |bibcode=2000PNAS...97.4233W }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal   |vauthors=Xu J, Paquet M, Lau AG, etal |title=beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41310–7 |year= 2001 |pmid= 11526121 |doi= 10.1074/jbc.M107480200 }}
*{{cite journal | author=Ide N, Hata Y, Deguchi M, ''et al.'' |title=Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 456-61 |year= 1999 |pmid= 10080919 |doi= 10.1006/bbrc.1999.0364 }}
*{{cite journal   |vauthors=Vazquez F, Grossman SR, Takahashi Y, etal |title=Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48627–30 |year= 2002 |pmid= 11707428 |doi= 10.1074/jbc.C100556200 }}
*{{cite journal | author=Shoji H, Tsuchida K, Kishi H, ''et al.'' |title=Identification and characterization of a PDZ protein that interacts with activin type II receptors. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5485-92 |year= 2000 |pmid= 10681527 |doi=  }}
*{{cite journal   |vauthors=Nishimura W, Yao I, Iida J, etal |title=Interaction of synaptic scaffolding molecule and Beta -catenin. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 757–65 |year= 2002 |pmid= 11826105 |doi=  }}
*{{cite journal  | author=Wu X, Hepner K, Castelino-Prabhu S, ''et al.'' |title=Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4233-8 |year= 2000 |pmid= 10760291 |doi=  }}
*{{cite journal  |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal | author=Xu J, Paquet M, Lau AG, ''et al.'' |title=beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41310-7 |year= 2001 |pmid= 11526121 |doi= 10.1074/jbc.M107480200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Vazquez F, Grossman SR, Takahashi Y, ''et al.'' |title=Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48627-30 |year= 2002 |pmid= 11707428 |doi= 10.1074/jbc.C100556200 }}
*{{cite journal   |vauthors=Yap CC, Muto Y, Kishida H, etal |title=PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 4 |pages= 1122–8 |year= 2003 |pmid= 12589829 |doi=10.1016/S0006-291X(03)00070-6 }}
*{{cite journal | author=Nishimura W, Yao I, Iida J, ''et al.'' |title=Interaction of synaptic scaffolding molecule and Beta -catenin. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 757-65 |year= 2002 |pmid= 11826105 |doi=  }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |bibcode=2003Sci...300..767S }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Evgrafov OV, Mersiyanova I, Irobi J, etal |title=Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 602–6 |year= 2004 |pmid= 15122254 |doi= 10.1038/ng1354 }}
*{{cite journal | author=Yap CC, Muto Y, Kishida H, ''et al.'' |title=PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 4 |pages= 1122-8 |year= 2003 |pmid= 12589829 |doi=  }}
*{{cite journal   |vauthors=Franklin JL, Yoshiura K, Dempsey PJ, etal |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457–70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Hu Y, Li Z, Guo L, etal |title=MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. |journal=Arch. Biochem. Biophys. |volume=467 |issue= 1 |pages= 1–9 |year= 2007 |pmid= 17880912 |doi= 10.1016/j.abb.2007.07.027 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Evgrafov OV, Mersiyanova I, Irobi J, ''et al.'' |title=Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 602-6 |year= 2004 |pmid= 15122254 |doi= 10.1038/ng1354 }}
*{{cite journal | author=Franklin JL, Yoshiura K, Dempsey PJ, ''et al.'' |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457-70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }}
*{{cite journal | author=Hu Y, Li Z, Guo L, ''et al.'' |title=MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. |journal=Arch. Biochem. Biophys. |volume=467 |issue= 1 |pages= 1-9 |year= 2007 |pmid= 17880912 |doi= 10.1016/j.abb.2007.07.027 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9863}}


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{{WikiDoc Sources}}

Latest revision as of 03:36, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.[1][2][3]

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[3]

Interactions

MAGI2 has been shown to interact with ATN1[4] and PTEN (gene).

References

  1. ↑ Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H (Mar 2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors". J Biol Chem. 275 (8): 5485–92. doi:10.1074/jbc.275.8.5485. PMID 10681527.
  2. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  3. ↑ 3.0 3.1 "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2".
  4. ↑ Wood, J D; Yuan J; Margolis R L; Colomer V; Duan K; Kushi J; Kaminsky Z; Kleiderlein J J; Sharp A H; Ross C A (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. UNITED STATES. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. ISSN 1044-7431. PMID 9647693.

Further reading


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