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*{{cite journal | author=Fujioka Y |title=MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45137–45144 |year= 2002 |pmid= 11567024 |doi= 10.1074/jbc.M106127200 |name-list-format=vanc| author2=Taira T | author3=Maeda Y | display-authors=3 | last4=Tanaka | first4=S | last5=Nishihara | first5=H | last6=Iguchi-Ariga | first6=SM | last7=Nagashima | first7=K | last8=Ariga | first8=H }} | *{{cite journal | author=Fujioka Y |title=MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45137–45144 |year= 2002 |pmid= 11567024 |doi= 10.1074/jbc.M106127200 |name-list-format=vanc| author2=Taira T | author3=Maeda Y | display-authors=3 | last4=Tanaka | first4=S | last5=Nishihara | first5=H | last6=Iguchi-Ariga | first6=SM | last7=Nagashima | first7=K | last8=Ariga | first8=H }} | ||
*{{cite journal | author=Watanabe K |title=Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15113–15123 |year= 2002 |pmid= 11844794 |doi= 10.1074/jbc.M111281200 |name-list-format=vanc| author2=Ozaki T | author3=Nakagawa T | display-authors=3 | last4=Miyazaki | first4=K | last5=Takahashi | first5=M | last6=Hosoda | first6=M | last7=Hayashi | first7=S | last8=Todo | first8=S | last9=Nakagawara | first9=A }} | *{{cite journal | author=Watanabe K |title=Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15113–15123 |year= 2002 |pmid= 11844794 |doi= 10.1074/jbc.M111281200 |name-list-format=vanc| author2=Ozaki T | author3=Nakagawa T | display-authors=3 | last4=Miyazaki | first4=K | last5=Takahashi | first5=M | last6=Hosoda | first6=M | last7=Hayashi | first7=S | last8=Todo | first8=S | last9=Nakagawara | first9=A }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author=Simons CT |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196–4203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200 |name-list-format=vanc| author2=Staes A | author3=Rommelaere H | display-authors=3 | last4=Ampe | first4=C | last5=Lewis | first5=SA | last6=Cowan | first6=NJ }} | *{{cite journal | author=Simons CT |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196–4203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200 |name-list-format=vanc| author2=Staes A | author3=Rommelaere H | display-authors=3 | last4=Ampe | first4=C | last5=Lewis | first5=SA | last6=Cowan | first6=NJ }} | ||
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
Latest revision as of 19:41, 25 June 2018
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Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.[1][2][3]
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.[3]
Interactions
PFDN5 has been shown to interact with Myc.[2][4]
References
- ↑ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–873. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229.
- ↑ 2.0 2.1 Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (Dec 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". J Biol Chem. 273 (45): 29794–29800. doi:10.1074/jbc.273.45.29794. PMID 9792694.
- ↑ 3.0 3.1 "Entrez Gene: PFDN5 prefoldin subunit 5".
- ↑ Fujioka, Y; Taira T; Maeda Y; Tanaka S; Nishihara H; Iguchi-Ariga S M; Nagashima K; Ariga H (Nov 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". J. Biol. Chem. United States. 276 (48): 45137–45144. doi:10.1074/jbc.M106127200. ISSN 0021-9258. PMID 11567024.
Further reading
- Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins". J. Cell Biol. 145 (2): 265–277. doi:10.1083/jcb.145.2.265. PMC 2133115. PMID 10209023.
- Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–991. doi:10.1038/14870. PMID 10542082.
- Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–41028. doi:10.1074/jbc.M106591200. PMID 11535601.
- Fujioka Y, Taira T, Maeda Y, et al. (2002). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". J. Biol. Chem. 276 (48): 45137–45144. doi:10.1074/jbc.M106127200. PMID 11567024.
- Watanabe K, Ozaki T, Nakagawa T, et al. (2002). "Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function". J. Biol. Chem. 277 (17): 15113–15123. doi:10.1074/jbc.M111281200. PMID 11844794.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–4203. doi:10.1074/jbc.M306053200. PMID 14634002.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–3884. doi:10.1002/pmic.200401239. PMID 16130169.
- Hagio Y, Kimura Y, Taira T, et al. (2006). "Distinct localizations and repression activities of MM-1 isoforms toward c-Myc". J. Cell. Biochem. 97 (1): 145–155. doi:10.1002/jcb.20619. PMID 16173081.
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