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| __NOTOC__
| | #Redirect[[Nephritic syndrome#Laboratory Findings]] |
| {{Nephritic syndrome}}
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| {{CMG}}; {{AE}} [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]]
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| ==Overview==
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| Laboratory work-up must be directed to first identify the exact diagnosis of nephritic syndrome by ruling out common etiologies, and to monitor disease progression and renal function. Work-up might be different from one individual to another based on the patient's presentation and medical history and physical examination findings.
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| ==Laboratory Findings==
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| ===Initial Work-Up===
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| ====Blood Work-up====
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| *[[Complete blood count]] ([[CBC]])
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| *[[Serum electrolyte]]s
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| *[[Serum creatinine]]
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| *[[Blood urea nitrogen]] ([[BUN]])
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| *[[Erythrocyte sedimentation rate]] ([[ESR]]) and [[C-reactive protein]]
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| Findings associated with [[glomerulonephritis]] include [[anemia]], [[leukocytosis]], and electrolyte disturbances such as [[hyperkalemia]]. [[Creatinine]] and [[BUN]] are required to monitor [[renal function]], calculate e[[GFR]], and possible renal deterioration.
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| Inflammatory markers, such as [[CRP]] and [[ESR]], may or may not be elevated in acute [[glomerulonephritis]]. They may be helpful in the diagnosis of systemic illnesses, such as [[malignancies]] or [[vasculitides]].
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| ====Urinalysis====
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| A urinalysis is always recommended in acute glomerulonephritis, looking for:
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| *[[Hematuria]]
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| *[[Proteinuria]]
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| *[[RBC cast]]s
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| *[[Urine culture]]
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| ===Further Work-Up===
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| A more extensive work-up may be necessary for patients who present with symptoms of signs consistent with secondary glomerulonephritis. Work-up includes, but is not limited to:
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| *[[Complement]] levels
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| *[[Blood culture]]
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| *[[Streptozyme test]] ([[ASO titer]])
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| *[[Streptococcal antigen]]s, such as nephritis-associated protease (NAPR), [[DNase]], [[streptolysin O]], [[streptokinase]], and [[hyaluronidase]]
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| *[[ANA]] profile
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| *[[c-ANCA]] and [[p-ANCA]]
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| *[[HBV]] and [[HCV]] serologies
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| ==References==
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| {{reflist|2}}
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| {{WH}}
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| {{WS}}
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| [[Category:Needs content]]
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| [[Category:Disease]]
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| [[Category:Nephrology]]
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| [[Category:Syndromes]]
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| [[Category:Pediatrics]]
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