Niclosamide: Difference between revisions

Latest revision as of 21:13, 6 January 2014

Niclosamide
YOMESAN^® Package Insert
Clinical Pharmacology
Indications
Contraindications
Side Effects
Overdosage
Dosage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niclosamide is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans.

It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.

It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.

Niclosamide molecules are lethal to tapeworms upon contact.

US Brand Names

NICLOCIDE^®, YOMESAN^® (DISCONTINUED)

FDA Package Insert

Mechanism of Action

Niclosamide uncouples oxidative phosphorylation in the tapeworm.^[1]

References

↑ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[pmid-1] Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[1]

@@ Line 5: / Line 5: @@
 ==Overview==
-'''Niclosamide''' (trade name '''Niclocide''') is a [[teniacide]] ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans. It is also used as a [[piscicide]].
+Niclosamide is a teniacide ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans.
 It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat [[tapeworms]] and is not effective against worms such as [[pinworms]] or [[roundworms]].
@@ Line 19: / Line 19: @@
 ==US Brand Names==
-NICLOCIDE, YOMESAN (DISCONTINUED)
+NICLOCIDE<sup>®</sup>, YOMESAN<sup>®</sup> (''DISCONTINUED'')
 ==FDA Package Insert==
-'''  [[Niclosamide description|Description]]'''
+'''  [[Niclosamide clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Niclosamide clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Niclosamide indications|Indications]]'''
-'''| [[Niclosamide microbiology|Microbiology]]'''
-'''| [[Niclosamide indications and usage|Indications and Usage]]'''
 '''| [[Niclosamide contraindications|Contraindications]]'''
-'''| [[Niclosamide warnings and precautions|Warnings and Precautions]]'''
+'''| [[Niclosamide side effects|Side Effects]]'''
-'''| [[Niclosamide adverse reactions|Adverse Reactions]]'''
-'''| [[Niclosamide drug interactions|Drug Interactions]]'''
 '''| [[Niclosamide overdosage|Overdosage]]'''
-'''| [[Niclosamide clinical studies|Clinical Studies]]'''
+'''| [[Niclosamide dosage|Dosage]]'''
-'''| [[Niclosamide dosage and administration|Dosage and Administration]]'''
-'''| [[Niclosamide how supplied|How Supplied]]'''
-'''| [[Niclosamide labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
-According to an article in Nature,<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation |journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref> niclosamide uncouples oxidative phosphorylation in the tapeworm.
+Niclosamide uncouples oxidative phosphorylation in the tapeworm.<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation|journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref>
 ==References==