Niclosamide: Difference between revisions

Latest revision as of 21:13, 6 January 2014

Niclosamide
YOMESAN^® Package Insert
Clinical Pharmacology
Indications
Contraindications
Side Effects
Overdosage
Dosage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niclosamide is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans.

It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.

It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.

Niclosamide molecules are lethal to tapeworms upon contact.

US Brand Names

NICLOCIDE^®, YOMESAN^® (DISCONTINUED)

FDA Package Insert

Mechanism of Action

Niclosamide uncouples oxidative phosphorylation in the tapeworm.^[1]

References

↑ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[pmid-1] Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[1]

@@ Line 1: / Line 1: @@
-{{Drugbox|
+__NOTOC__
-|IUPAC_name =
+{{Niclosamide}}
-| image = Niclosamide.png
+{{CMG}}
-| CAS_number=50-65-7
-| ATC_prefix=P02
-| ATC_suffix=DA01
-| ATC_supplemental=
-| PubChem=4477
-| DrugBank=
-| C=13 | H=8 | Cl=2 | N=2 | O=4
-| molecular_weight = 327.119 g/mol
-| bioavailability=
-| metabolism =
-| elimination_half-life=
-| excretion =
-| pregnancy_category =
-| legal_status =
-| routes_of_administration=
-}}
-'''Niclosamide''' (trade name '''Niclocide''') is a [[teniacide]] ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans. It is also used as a [[piscicide]].
-It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat [[tapeworms]] and is not effective against worms such as [[pinworms]] or [[roundworms]].
+==Overview==
-It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
+Niclosamide is a teniacide ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans.
-Niclosamide molecules are lethal to tapeworms upon contact.
+It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat [[tapeworms]] and is not effective against worms such as [[pinworms]] or [[roundworms]].
-== Side effects ==
+It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
-The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis.  Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.
+Niclosamide molecules are lethal to tapeworms upon contact.
-== Mechanism of action ==
+==Category==
-According to an article in Nature,<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation |journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref> niclosamide uncouples oxidative phosphorylation in the tapeworm.
+Anthelmintic
-== References ==
+==US Brand Names==
-<references/>
-* {{cite book |author=Taber, Clarence Wilbur; Venes, Donald; Thomas, Clayton L. |title=Taber's cyclopedic medical dictionary |publisher=F.A.Davis Co |location=Philadelphia |year=2001 |pages= |isbn= |oclc= |doi=}}
-*Additional Medication Information:[http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/.html Medline]
-*http://www.drugs.com/cons/Niclosamide.html
+NICLOCIDE<sup>®</sup>, YOMESAN<sup>®</sup> (''DISCONTINUED'')
-{{Pharma-stub}}
+==FDA Package Insert==
-{{Anthelmintics}}
-[[nl:niclosamide]]
+'''  [[Niclosamide clinical pharmacology|Clinical Pharmacology]]'''
-[[Category:Anthelmintics]]
+'''| [[Niclosamide indications|Indications]]'''
-{{WikiDoc Sources}}
+'''| [[Niclosamide contraindications|Contraindications]]'''
+'''| [[Niclosamide side effects|Side Effects]]'''
+'''| [[Niclosamide overdosage|Overdosage]]'''
+'''| [[Niclosamide dosage|Dosage]]'''
+==Mechanism of Action==
+Niclosamide uncouples oxidative phosphorylation in the tapeworm.<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation|journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref>
+==References==
+{{Reflist|2}}
+[[Category:Antibiotics]]
+[[Category:Wikinfect]]