Noncompaction cardiomyopathy biopsy: Difference between revisions
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==Overview== | ==Overview== | ||
Both skeletal and cardiac biopsies may reveal abnormal histologic findings. | |||
==Skeletal Biopsy== | |||
A skeletal biopsy can be performed which may demonstrate inclusion bodies or [[myopathic]] changes <ref>Botto, LD. Left ventricular noncompaction. Orphanet encyclopedia. http://www.orpha.net/data/patho/GB/uk-LVNC.pdf </ref>. | A skeletal biopsy can be performed which may demonstrate inclusion bodies or [[myopathic]] changes <ref>Botto, LD. Left ventricular noncompaction. Orphanet encyclopedia. http://www.orpha.net/data/patho/GB/uk-LVNC.pdf </ref>. | ||
==Cardiac Biopsy== | |||
*Interstitial [[fibrosis]] was observed in 5/5 patients with isolated noncompaction cardiomyopathy who underwent [[right ventricular biopsy]]<ref> | |||
Hamamichi Y, Ichida F, Hashimoto I, et al. Isolated noncompaction of the ventricular myocardium: ultrafast computer tomography and magnetic resonance imaging. Int J Cardiovasc Imaging. 2001; 17: 305–314.</ref> | |||
*Endomyocardial thickening and subendocardial [[fibroelastosis]] was observed in 3/5 patients who underwent [[right ventricular biopsy]]. | |||
*Myocyte [[necrosis]] has been observed in areas of trabeculation <ref>Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.</ref><ref>Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.</ref>. | |||
==References== | ==References== | ||
Latest revision as of 13:45, 6 August 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Both skeletal and cardiac biopsies may reveal abnormal histologic findings.
Skeletal Biopsy
A skeletal biopsy can be performed which may demonstrate inclusion bodies or myopathic changes [1].
Cardiac Biopsy
- Interstitial fibrosis was observed in 5/5 patients with isolated noncompaction cardiomyopathy who underwent right ventricular biopsy[2]
- Endomyocardial thickening and subendocardial fibroelastosis was observed in 3/5 patients who underwent right ventricular biopsy.
- Myocyte necrosis has been observed in areas of trabeculation [3][4].
References
- ↑ Botto, LD. Left ventricular noncompaction. Orphanet encyclopedia. http://www.orpha.net/data/patho/GB/uk-LVNC.pdf
- ↑ Hamamichi Y, Ichida F, Hashimoto I, et al. Isolated noncompaction of the ventricular myocardium: ultrafast computer tomography and magnetic resonance imaging. Int J Cardiovasc Imaging. 2001; 17: 305–314.
- ↑ Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
- ↑ Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.