Cardiac tumors causes: Difference between revisions

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{{Cardiac tumors}}
{{Cardiac tumors}}
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==Overview==
==Overview==
* Numerous genetic disorders are associated with cardiac tumors however, till now no direct causes have been identified.


==Causes==
==Causes==
*Many genetic conditions are strongly associated with a large number of heart tumors. Some of them are as follows:<ref name="pmid29214333">{{cite journal| author=Lee E, Mahani MG, Lu JC, Dorfman AL, Srinivasan A, Agarwal PP| title=Primary cardiac tumors associated with genetic syndromes: a comprehensive review. | journal=Pediatr Radiol | year= 2018 | volume= 48 | issue= 2 | pages= 156-164 | pmid=29214333 | doi=10.1007/s00247-017-4027-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29214333  }} </ref>
{| class="wikitable"
|+ Cardiac tumors genetic causes
|-
! Tumor !! Syndrome !! Gene Associated with syndrome
|-
| [[Rhabdomyoma]] || [[Tuberous Sclerosis]] || TSC1 or hamartin
TSC2 or tuberin
|-
| [[Fibroma]] || [[Gorlin Syndrome]] || PATCHED gene
|-
| [[Myxoma]] || [[Carney Complex]] || Inactivating mutation of PRKARA1A
Activating pathogenic variant of PRKACA gene
|-
| [[Paraganglioma]]|| [[Carney triad]]|| No known gene associations
|-                 
| [[Paraganglioma]]                || [[Hereditary Paraganglioma]] || Mutation of succinate dehydrogenase subunit
SDHAF2 gene, and possibly MAX gene but these mutations are rare
|-
| [[Paraganglioma]] || [[Von Hippel Lindau]] || VHL gene
|-
| [[Paraganglioma]] || [[Neurofibromatosis type 1]] || NF1 gene
|}


==References==
==References==
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Latest revision as of 16:26, 14 July 2022

Cardiac tumors Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dheeraj Makkar, M.D.[2]

Overview

  • Numerous genetic disorders are associated with cardiac tumors however, till now no direct causes have been identified.

Causes

  • Many genetic conditions are strongly associated with a large number of heart tumors. Some of them are as follows:[1]
Cardiac tumors genetic causes
Tumor Syndrome Gene Associated with syndrome
Rhabdomyoma Tuberous Sclerosis TSC1 or hamartin

TSC2 or tuberin

Fibroma Gorlin Syndrome PATCHED gene
Myxoma Carney Complex Inactivating mutation of PRKARA1A

Activating pathogenic variant of PRKACA gene

Paraganglioma Carney triad No known gene associations
Paraganglioma Hereditary Paraganglioma Mutation of succinate dehydrogenase subunit

SDHAF2 gene, and possibly MAX gene but these mutations are rare

Paraganglioma Von Hippel Lindau VHL gene
Paraganglioma Neurofibromatosis type 1 NF1 gene


References

  1. Lee E, Mahani MG, Lu JC, Dorfman AL, Srinivasan A, Agarwal PP (2018). "Primary cardiac tumors associated with genetic syndromes: a comprehensive review". Pediatr Radiol. 48 (2): 156–164. doi:10.1007/s00247-017-4027-2. PMID 29214333.

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