Fever of unknown origin overview: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{| class="infobox" style="float: right;"
{| class="infobox" style="float: right;"
| style="vertical-align: middle; padding: 5px;" align=center | [[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]]
| style="vertical-align: middle; padding: 5px;" align="center" |[[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]]
| style="vertical-align: middle; padding: 5px;" align=center | [[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
| style="vertical-align: middle; padding: 5px;" align="center" |[[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
|}
|}
{{Fever of unknown origin}}
{{Fever of unknown origin}}
Line 10: Line 10:


==Overview==
==Overview==
Fever of unknown origin (FUO) refers to a condition in which the patient has an elevated temperature but despite investigations by a physician no explanation has been found.<ref name="Mandell">
Fever of unknown origin (FUO) was formally defined for the first time by Petersdorf and Beeson: “[[fever]] above 38.3° C (100.9° F) on several occasions, persisting without diagnosis for at least three weeks in spite of at least one week’s investigation in hospital.ʺ<ref name="AuwaerterWright2020">{{cite journal|last1=Auwaerter|first1=Paul G|last2=Wright|first2=William F|title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma|journal=Open Forum Infectious Diseases|volume=7|issue=5|year=2020|issn=2328-8957|doi=10.1093/ofid/ofaa132}}</ref>
[http://www.ppidonline.com/ Mandell's Principles and Practices of Infection Diseases] 6th Edition (2004) by Gerald L. Mandell MD, MACP, John E. Bennett MD, Raphael Dolin MD, ISBN 0-443-06643-4 · Hardback · 4016 Pages Churchill Livingstone </ref><ref name="Harrison">[http://books.mcgraw-hill.com/medical/harrisons/ Harrison's Principles of Internal Medicine] 16th Edition, The McGraw-Hill Companies, ISBN 0-07-140235-7</ref><ref name="Oxford"> [http://www.oup.com/us/catalog/general/subject/Medicine/PrimaryCare/?ci=0192629220&view=usa The Oxford Textbook of Medicine] Edited by David A. Warrell, Timothy M. Cox and John D. Firth with Edward J. Benz, Fourth Edition (2003), Oxford University Press, ISBN 0-19-262922-0</ref><ref name="Cecil">
[http://www.cecilmedicine.com/buy.cfm?book=goldman Cecil Textbook of Medicine] by Lee Goldman, Dennis Ausiello, 22nd Edition (2003), W.B. Saunders Company, ISBN 0-7216-9652-X</ref><ref name="IrwinRippe"> [http://www.lww.com/product/?0-7817-3548-3 Irwin and Rippe's Intensive Care Medicine] by Irwin and Rippe, Fifth Edition (2003), Lippincott Williams & Wilkins, ISBN 0-7817-3548-3</ref>


If the cause is found it usually is a [[diagnosis of exclusion]], that is, by eliminating all possibilities until only one explanation remains, and taking this as the correct one.
Durack and Street made four different categories of fever of unknown origin in 1991:


==Pathophysiology==
#Classic FUO
The current definition requires three outpatient visits or three days in hospital or 1 week of "intelligent and invasive" ambulatory investigation.
#[[Nosocomial]] FUO
#Neutropenic FUO
#[[Human Immunodeficiency Virus (HIV)|HIV]] related FUO<ref name="AuwaerterWright20202">{{cite journal|last1=Auwaerter|first1=Paul G|last2=Wright|first2=William F|title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma|journal=Open Forum Infectious Diseases|volume=7|issue=5|year=2020|issn=2328-8957|doi=10.1093/ofid/ofaa132}}</ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Ailments of unknown etiology]]
[[Category:Ailments of unknown etiology]]

Latest revision as of 15:44, 25 January 2021

Resident
Survival
Guide

Fever of unknown origin Microchapters

Home

Patient Information

Overview

Historical perspective

Pathophysiology

Causes

Differentiating Fever of unknown origin from other Diseases

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and ultrasound

CT scan

MRI

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Fever of unknown origin overview On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Fever of unknown origin overview

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Fever of unknown origin overview

CDC on Fever of unknown origin overview

Fever of unknown origin overview in the news

Blogs on Fever of unknown origin overview

Directions to Hospitals Treating Fever of unknown origin

Risk calculators and risk factors for Fever of unknown origin overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin

Overview

Fever of unknown origin (FUO) was formally defined for the first time by Petersdorf and Beeson: “fever above 38.3° C (100.9° F) on several occasions, persisting without diagnosis for at least three weeks in spite of at least one week’s investigation in hospital.ʺ[1]

Durack and Street made four different categories of fever of unknown origin in 1991:

  1. Classic FUO
  2. Nosocomial FUO
  3. Neutropenic FUO
  4. HIV related FUO[2]

References

  1. Auwaerter, Paul G; Wright, William F (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSN 2328-8957.
  2. Auwaerter, Paul G; Wright, William F (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSN 2328-8957.