Congenital syphilis other diagnostic studies: Difference between revisions

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{{Congenital syphilis}}
{{Congenital syphilis}}
{{CMG}}; {{AE}} {{ADI}}{{AKI}}
==Overview==
Pathologic examination of the [[placenta]] or [[umbilical cord]] by using specific fluorescent antitreponemal antibody staining and CSF analysis can be done.
==Other Diagnostic Findings==
===CSF Analysis===
'''Indications : ''' [[Lumbar puncture]] is indicated in the following situations.<ref name="Phiske2014">{{cite journal|last1=Phiske|first1=MeghanaMadhukar|title=Current trends in congenital syphilis|journal=Indian Journal of Sexually Transmitted Diseases and AIDS|volume=35|issue=1|year=2014|pages=12|issn=0253-7184|doi=10.4103/0253-7184.132404}}</ref>
*If the [[infant]] or [[child]] has [[signs]] and [[symptoms]] of [[congenital Syphilis]].
*If there is no documentation of treatment for [[maternal]] infection during the period of [[gestation]].
*If the mother was treated within 4 weeks of [[delivery]].
*If the mother was inadequately treated or documentation of the treatment is incomplete.
*A four-fold decline in [[titer]] following therapy in the mother is not documented.
'''CSF Findings:'''
*Reactive [[CSF]] [[VDRL]]. <ref name="pmid26042815">{{cite journal| author=Workowski KA, Bolan GA, Centers for Disease Control and Prevention| title=Sexually transmitted diseases treatment guidelines, 2015. | journal=MMWR Recomm Rep | year= 2015 | volume= 64 | issue= RR-03 | pages= 1-137 | pmid=26042815 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26042815  }} </ref>
*[[CSF pleocytosis]](>25 white blood cells [WBC]/microL for infants <1 month)
*Elevated [[CSF]] [[protein]] (>150 mg/dL in term infants <1 month of age and >170 mg/dL in preterm infants <1 month of age)
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Disease]]
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Latest revision as of 21:04, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]Aravind Kuchkuntla, M.B.B.S[3]

Overview

Pathologic examination of the placenta or umbilical cord by using specific fluorescent antitreponemal antibody staining and CSF analysis can be done.

Other Diagnostic Findings

CSF Analysis

Indications : Lumbar puncture is indicated in the following situations.[1]

  • If the infant or child has signs and symptoms of congenital Syphilis.
  • If there is no documentation of treatment for maternal infection during the period of gestation.
  • If the mother was treated within 4 weeks of delivery.
  • If the mother was inadequately treated or documentation of the treatment is incomplete.
  • A four-fold decline in titer following therapy in the mother is not documented.

CSF Findings:

  • Reactive CSF VDRL. [2]
  • CSF pleocytosis(>25 white blood cells [WBC]/microL for infants <1 month)
  • Elevated CSF protein (>150 mg/dL in term infants <1 month of age and >170 mg/dL in preterm infants <1 month of age)


References

  1. Phiske, MeghanaMadhukar (2014). "Current trends in congenital syphilis". Indian Journal of Sexually Transmitted Diseases and AIDS. 35 (1): 12. doi:10.4103/0253-7184.132404. ISSN 0253-7184.
  2. Workowski KA, Bolan GA, Centers for Disease Control and Prevention (2015). "Sexually transmitted diseases treatment guidelines, 2015". MMWR Recomm Rep. 64 (RR-03): 1–137. PMID 26042815.

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