UBE1C: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
{{Infobox protein family
| update_page = yes
| Symbol = E2_bind
| require_manual_inspection = no
| Name = E2 binding domain
| update_protein_box = yes
| image = PDB 1r4n EBI.jpg
| update_summary = yes
| width =  
| update_citations = yes
| caption = appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
}}
| Pfam = PF08825
 
| Pfam_clan =   
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
| InterPro = IPR014929
{{GNF_Protein_box
| SMART =  
| image = PBB_Protein_UBE1C_image.jpg
| PROSITE =  
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r4m.
| MEROPS =  
| PDB = {{PDB2|1r4m}}, {{PDB2|1r4n}}, {{PDB2|1tt5}}, {{PDB2|1y8x}}, {{PDB2|1yov}}, {{PDB2|2nvu}}
| SCOP =  
| Name = Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
| TCDB =  
| HGNCid = 12470
| OPM family =  
| Symbol = UBE1C
| OPM protein =  
| AltSymbols =; DKFZp566J164; MGC22384; UBA3; hUba3
| CAZy =  
| OMIM = 603172
| CDD =  
| ECnumber = 
| Homologene = 2951
| MGIid = 1341217
| GeneAtlas_image1 = PBB_GE_UBE1C_209115_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004839 |text = ubiquitin activating enzyme activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000278 |text = mitotic cell cycle}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007113 |text = endomitotic cell cycle}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9039
    | Hs_Ensembl = ENSG00000144744
    | Hs_RefseqProtein = NP_003959
    | Hs_RefseqmRNA = NM_003968
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 69187278
    | Hs_GenLoc_end = 69212194
    | Hs_Uniprot = Q8TBC4
    | Mm_EntrezGene = 22200
    | Mm_Ensembl = ENSMUSG00000030061
    | Mm_RefseqmRNA = NM_011666
    | Mm_RefseqProtein = NP_035796
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 97149281
    | Mm_GenLoc_end = 97171023
    | Mm_Uniprot = Q3TG68
  }}
}}
}}
'''Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)''', also known as '''UBE1C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9039| accessdate = }}</ref>
'''NEDD8-activating enzyme E1 catalytic subunit''' is a [[protein]] that in humans is encoded by the ''UBA3'' [[gene]].<ref name="pmid9694792">{{cite journal |vauthors=Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S | title = A new NEDD8-ligating system for cullin-4A | journal = Genes Dev | volume = 12 | issue = 15 | pages = 2263–8 |date=August 1998 | pmid = 9694792 | pmc = 317039 | doi =10.1101/gad.12.15.2263  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9039| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9039| accessdate = }}</ref>
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a [[ubiquitin-like protein]], which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez"/>
}}
}}
This enzyme contains an E2 binding [[protein domain|domain]], which resembles [[ubiquitin]], and recruits the [[catalytic]] core of the E2 enzyme [[UBE2M]] (Ubc12) in a similar manner to that in which ubiquitin [[Protein-protein interaction|interact]]s with ubiquitin binding [[protein domain|domains]].<ref name="pmid15694336">{{cite journal |vauthors=Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA | title = Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 | journal = Mol. Cell | volume = 17 | issue = 3 | pages = 341–50 |date=February 2005 | pmid = 15694336 | doi = 10.1016/j.molcel.2004.12.020 | url = }}</ref>
==Interactions==
UBE1C has been shown to [[Protein-protein interaction|interact]] with [[NEDD8]],<ref name=pmid10207026>{{cite journal |doi=10.1074/jbc.274.17.12036 |last=Gong |first=L |authorlink= |author2=Yeh E T  |date=April 1999  |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway |journal=J. Biol. Chem. |volume=274 |issue=17 |pages=12036–42 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10207026 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[APPBP1]]<ref name=pmid10722740>{{cite journal |doi=10.1074/jbc.275.12.8929 |last=Chen |first=Y |authorlink= |author2=McPhie D L |author3=Hirschberg J |author4=Neve R L  |date=March 2000  |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons |journal=J. Biol. Chem. |volume=275 |issue=12 |pages=8929–35 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10722740 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[UBE2M]].<ref name="pmid15694336" />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Osaka F, Kawasaki H, Aida N, ''et al.'' |title=A new NEDD8-ligating system for cullin-4A. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2263-8 |year= 1998 |pmid= 9694792 |doi=  }}
*{{cite journal  |vauthors=Gong L, Yeh ET |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 12036–42 |year= 1999 |pmid= 10207026 |doi=10.1074/jbc.274.17.12036 }}
*{{cite journal  | author=Gong L, Yeh ET |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 12036-42 |year= 1999 |pmid= 10207026 |doi= }}
*{{cite journal  |vauthors=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168–77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855 }}
*{{cite journal  | author=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168-77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855 }}
*{{cite journal  |vauthors=Chen Y, McPhie DL, Hirschberg J, Neve RL |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8929–35 |year= 2000 |pmid= 10722740 |doi=10.1074/jbc.275.12.8929  }}
*{{cite journal  | author=Chen Y, McPhie DL, Hirschberg J, Neve RL |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8929-35 |year= 2000 |pmid= 10722740 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Walden H, Podgorski MS, Schulman BA |title=Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. |journal=Nature |volume=422 |issue= 6929 |pages= 330–4 |year= 2003 |pmid= 12646924 |doi= 10.1038/nature01456 |bibcode=2003Natur.422..330W }}
*{{cite journal  | author=Walden H, Podgorski MS, Schulman BA |title=Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. |journal=Nature |volume=422 |issue= 6929 |pages= 330-4 |year= 2003 |pmid= 12646924 |doi= 10.1038/nature01456 }}
*{{cite journal  |vauthors=Bohnsack RN, Haas AL |title=Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26823–30 |year= 2003 |pmid= 12740388 |doi= 10.1074/jbc.M303177200 }}
*{{cite journal | author=Bohnsack RN, Haas AL |title=Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26823-30 |year= 2003 |pmid= 12740388 |doi= 10.1074/jbc.M303177200 }}
*{{cite journal   |vauthors=Walden H, Podgorski MS, Huang DT, etal |title=The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1427–37 |year= 2004 |pmid= 14690597 |doi=10.1016/S1097-2765(03)00452-0  }}
*{{cite journal | author=Walden H, Podgorski MS, Huang DT, ''et al.'' |title=The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1427-37 |year= 2004 |pmid= 14690597 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Huang DT, Miller DW, Mathew R, etal |title=A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 927–35 |year= 2004 |pmid= 15361859 |doi= 10.1038/nsmb826  | pmc=2862556 }}
*{{cite journal | author=Huang DT, Miller DW, Mathew R, ''et al.'' |title=A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 927-35 |year= 2004 |pmid= 15361859 |doi= 10.1038/nsmb826 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Huang DT, Paydar A, Zhuang M, etal |title=Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 341–50 |year= 2005 |pmid= 15694336 |doi= 10.1016/j.molcel.2004.12.020 }}
*{{cite journal | author=Huang DT, Paydar A, Zhuang M, ''et al.'' |title=Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 341-50 |year= 2005 |pmid= 15694336 |doi= 10.1016/j.molcel.2004.12.020 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Hiller M, Huse K, Szafranski K, etal |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 | pmc=1380236 }}
*{{cite journal | author=Hiller M, Huse K, Szafranski K, ''et al.'' |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291-302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 }}
*{{cite journal  |vauthors=Norman JA, Shiekhattar R |title=Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. |journal=Biochemistry |volume=45 |issue= 9 |pages= 3014–9 |year= 2006 |pmid= 16503656 |doi= 10.1021/bi052435a }}
*{{cite journal  | author=Norman JA, Shiekhattar R |title=Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. |journal=Biochemistry |volume=45 |issue= 9 |pages= 3014-9 |year= 2006 |pmid= 16503656 |doi= 10.1021/bi052435a }}
*{{cite journal   |vauthors=Li T, Santockyte R, Shen RF, etal |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70–4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002 }}
*{{cite journal | author=Li T, Santockyte R, Shen RF, ''et al.'' |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70-4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9039}}
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{{InterPro content|IPR014929}}
[[Category:Protein domains]]


{{protein-stub}}
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Latest revision as of 08:50, 11 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
E2 binding domain
File:PDB 1r4n EBI.jpg
appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
Identifiers
SymbolE2_bind
PfamPF08825
InterProIPR014929

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.[3]

Interactions

UBE1C has been shown to interact with NEDD8,[4] APPBP1[5] and UBE2M.[3]

References

  1. ↑ Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (August 1998). "A new NEDD8-ligating system for cullin-4A". Genes Dev. 12 (15): 2263–8. doi:10.1101/gad.12.15.2263. PMC 317039. PMID 9694792.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)".
  3. ↑ 3.0 3.1 Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1". Mol. Cell. 17 (3): 341–50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336.
  4. ↑ Gong, L; Yeh E T (April 1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway". J. Biol. Chem. UNITED STATES. 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. ISSN 0021-9258. PMID 10207026.
  5. ↑ Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. UNITED STATES. 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740.

Further reading


This article incorporates text from the public domain Pfam and InterPro: IPR014929


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