Major histocompatibility complex, class I-related: Difference between revisions

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'''Major histocompatibility complex class I-related gene protein''' is a [[protein]] that in humans is encoded by the ''MR1'' [[gene]].<ref name="pmid7624800">{{cite journal |vauthors=Hashimoto K, Hirai M, Kurosawa Y | title = A gene outside the human MHC related to classical HLA class I genes | journal = Science | volume = 269 | issue = 5224 | pages = 693–5 |date=Aug 1995 | pmid = 7624800 | pmc =  | doi =10.1126/science.7624800 }}</ref><ref name="pmid9784382">{{cite journal |vauthors=Yamaguchi H, Kurosawa Y, Hashimoto K | title = Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 558–64 |date=Nov 1998 | pmid = 9784382 | pmc =  | doi = 10.1006/bbrc.1998.9353 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MR1 major histocompatibility complex, class I-related| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3140| accessdate = }}</ref> The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to [[Mucosal associated invariant T cell|mucosal associated invariant T cells]] for activation.<ref>{{Cite journal|last=Corbett|first=Alexandra J.|last2=Eckle|first2=Sidonia B. G.|last3=Birkinshaw|first3=Richard W.|last4=Liu|first4=Ligong|last5=Patel|first5=Onisha|last6=Mahony|first6=Jennifer|last7=Chen|first7=Zhenjun|last8=Reantragoon|first8=Rangsima|last9=Meehan|first9=Bronwyn|title=T-cell activation by transitory neo-antigens derived from distinct microbial pathways|url=http://www.nature.com/doifinder/10.1038/nature13160|journal=Nature|volume=509|issue=7500|pages=361–365|doi=10.1038/nature13160}}</ref><ref>{{Cite journal|last=Kjer-Nielsen|first=Lars|last2=Patel|first2=Onisha|last3=Corbett|first3=Alexandra J.|last4=Nours|first4=Jérôme Le|last5=Meehan|first5=Bronwyn|last6=Liu|first6=Ligong|last7=Bhati|first7=Mugdha|last8=Chen|first8=Zhenjun|last9=Kostenko|first9=Lyudmila|title=MR1 presents microbial vitamin B metabolites to MAIT cells|url=http://www.nature.com/doifinder/10.1038/nature11605|journal=Nature|doi=10.1038/nature11605}}</ref>
'''Major histocompatibility complex class I-related gene protein''' is a [[protein]] that in humans is encoded by the ''MR1'' [[gene]].<ref name="pmid7624800">{{cite journal | vauthors = Hashimoto K, Hirai M, Kurosawa Y | title = A gene outside the human MHC related to classical HLA class I genes | journal = Science | volume = 269 | issue = 5224 | pages = 693–5 | date = August 1995 | pmid = 7624800 | pmc =  | doi = 10.1126/science.7624800 }}</ref><ref name="pmid9784382">{{cite journal | vauthors = Yamaguchi H, Kurosawa Y, Hashimoto K | title = Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog | journal = Biochemical and Biophysical Research Communications | volume = 250 | issue = 3 | pages = 558–64 | date = September 1998 | pmid = 9784382 | pmc =  | doi = 10.1006/bbrc.1998.9353 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MR1 major histocompatibility complex, class I-related| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3140| access-date = }}</ref> Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.<ref name="UniProt">{{cite web|url=http://www.uniprot.org/uniprot/Q95460#sequences |title=UniProt, Q95460 }}</ref> The MR1 protein is able to bind to molecules derived from bacterial [[riboflavin]] [[biosynthesis]], and then present it to [[Mucosal associated invariant T cell|mucosal associated invariant T cells]] for activation.<ref>{{cite journal | vauthors = Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J | title = T-cell activation by transitory neo-antigens derived from distinct microbial pathways | journal = Nature | volume = 509 | issue = 7500 | pages = 361–5 | date = May 2014 | pmid = 24695216 | doi = 10.1038/nature13160 }}</ref><ref>{{cite journal | vauthors = Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J | title = MR1 presents microbial vitamin B metabolites to MAIT cells | journal = Nature | volume = 491 | issue = 7426 | pages = 717–23 | date = November 2012 | pmid = 23051753 | doi = 10.1038/nature11605 }}</ref> Within cells, MR1 is mostly stored inside the [[endoplasmic reticulum]], where the binding of bacterial riboflavin-related molecules to MR1 occurs, causing it to be sent to the cell surface for presentation.<ref>{{cite journal | vauthors = McWilliam HE, Eckle SB, Theodossis A, Liu L, Chen Z, Wubben JM, Fairlie DP, Strugnell RA, Mintern JD, McCluskey J, Rossjohn J, Villadangos JA | title = The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1 | journal = Nature Immunology | volume = 17 | issue = 5 | pages = 531–7 | date = May 2016 | pmid = 27043408 | doi = 10.1038/ni.3416 }}</ref>  


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== References ==
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==References==
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==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K | title = A highly conserved major histocompatibility complex class I-related gene in mammals | journal = Biochemical and Biophysical Research Communications | volume = 238 | issue = 3 | pages = 697–702 | date = September 1997 | pmid = 9325151 | doi = 10.1006/bbrc.1997.7379 }}
*{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal |vauthors=Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K |title=A highly conserved major histocompatibility complex class I-related gene in mammals. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 697–702 |year= 1997 |pmid= 9325151 |doi= 10.1006/bbrc.1997.7379 }}
* {{cite journal | vauthors = Riegert P, Wanner V, Bahram S | title = Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene | journal = Journal of Immunology | volume = 161 | issue = 8 | pages = 4066–77 | date = October 1998 | pmid = 9780177 | doi =  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Parra-Cuadrado JF, Navarro P, Mirones I, Setién F, Oteo M, Martínez-Naves E | title = A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene | journal = Tissue Antigens | volume = 56 | issue = 2 | pages = 170–2 | date = August 2000 | pmid = 11019920 | doi = 10.1034/j.1399-0039.2000.560211.x }}
*{{cite journal |vauthors=Riegert P, Wanner V, Bahram S |title=Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene. |journal=J. Immunol. |volume=161 |issue= 8 |pages= 4066–77 |year= 1998 |pmid= 9780177 |doi=  }}
* {{cite journal | vauthors = Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L | title = Biochemical features of the MHC-related protein 1 consistent with an immunological function | journal = Journal of Immunology | volume = 170 | issue = 12 | pages = 6090–8 | date = June 2003 | pmid = 12794138 | doi = 10.4049/jimmunol.170.12.6090 }}
*{{cite journal   |vauthors=Parra-Cuadrado JF, Navarro P, Mirones I, etal |title=A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene. |journal=Tissue Antigens |volume=56 |issue= 2 |pages= 170–2 |year= 2001 |pmid= 11019920 |doi=10.1034/j.1399-0039.2000.560211.x }}
* {{cite journal | vauthors = Hempelmann A, Kumar S, Muralitharan S, Sander T | title = Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia | journal = Neuroscience Letters | volume = 402 | issue = 1-2 | pages = 118–20 | date = July 2006 | pmid = 16632198 | doi = 10.1016/j.neulet.2006.03.048 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Miley MJ, Truscott SM, Yu YY, etal |title=Biochemical features of the MHC-related protein 1 consistent with an immunological function. |journal=J. Immunol. |volume=170 |issue= 12 |pages= 6090–8 |year= 2003 |pmid= 12794138 |doi= 10.4049/jimmunol.170.12.6090}}
*{{cite journal |vauthors=Hempelmann A, Kumar S, Muralitharan S, Sander T |title=Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia. |journal=Neurosci. Lett. |volume=402 |issue= 1-2 |pages= 118–20 |year= 2007 |pmid= 16632198 |doi= 10.1016/j.neulet.2006.03.048 }}
}}
{{refend}}
{{refend}}


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[[Category:Human proteins]]
[[Category:Human proteins]]


{{gene-1-stub}}
{{gene-1-stub}}

Latest revision as of 05:39, 9 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene.[1][2][3] Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.[4] The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to mucosal associated invariant T cells for activation.[5][6] Within cells, MR1 is mostly stored inside the endoplasmic reticulum, where the binding of bacterial riboflavin-related molecules to MR1 occurs, causing it to be sent to the cell surface for presentation.[7]

References

  1. ↑ Hashimoto K, Hirai M, Kurosawa Y (August 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID 7624800.
  2. ↑ Yamaguchi H, Kurosawa Y, Hashimoto K (September 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochemical and Biophysical Research Communications. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID 9784382.
  3. ↑ "Entrez Gene: MR1 major histocompatibility complex, class I-related".
  4. ↑ "UniProt, Q95460".
  5. ↑ Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J (May 2014). "T-cell activation by transitory neo-antigens derived from distinct microbial pathways". Nature. 509 (7500): 361–5. doi:10.1038/nature13160. PMID 24695216.
  6. ↑ Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J (November 2012). "MR1 presents microbial vitamin B metabolites to MAIT cells". Nature. 491 (7426): 717–23. doi:10.1038/nature11605. PMID 23051753.
  7. ↑ McWilliam HE, Eckle SB, Theodossis A, Liu L, Chen Z, Wubben JM, Fairlie DP, Strugnell RA, Mintern JD, McCluskey J, Rossjohn J, Villadangos JA (May 2016). "The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1". Nature Immunology. 17 (5): 531–7. doi:10.1038/ni.3416. PMID 27043408.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (September 1997). "A highly conserved major histocompatibility complex class I-related gene in mammals". Biochemical and Biophysical Research Communications. 238 (3): 697–702. doi:10.1006/bbrc.1997.7379. PMID 9325151.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Riegert P, Wanner V, Bahram S (October 1998). "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene". Journal of Immunology. 161 (8): 4066–77. PMID 9780177.
  • Parra-Cuadrado JF, Navarro P, Mirones I, Setién F, Oteo M, Martínez-Naves E (August 2000). "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene". Tissue Antigens. 56 (2): 170–2. doi:10.1034/j.1399-0039.2000.560211.x. PMID 11019920.
  • Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L (June 2003). "Biochemical features of the MHC-related protein 1 consistent with an immunological function". Journal of Immunology. 170 (12): 6090–8. doi:10.4049/jimmunol.170.12.6090. PMID 12794138.
  • Hempelmann A, Kumar S, Muralitharan S, Sander T (July 2006). "Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia". Neuroscience Letters. 402 (1–2): 118–20. doi:10.1016/j.neulet.2006.03.048. PMID 16632198.
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