SEPT8: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Septin-8''' is a [[protein]] that in humans is encoded by the ''SEPT8'' [[gene]].<ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Research | volume = 3 | issue = 5 | pages = 321–9, 341-54 | date = October 1996 | pmid = 9039502 | pmc =  | doi = 10.1093/dnares/3.5.321 }}</ref><ref name="pmid9149945">{{cite journal | vauthors = Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM | title = Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region | journal = Genome Research | volume = 7 | issue = 5 | pages = 495–512 | date = May 1997 | pmid = 9149945 | pmc = | doi = 10.1101/gr.7.5.495 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEPT8 septin 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23176| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Septin 8
| HGNCid = 16511
| Symbol = SEPT8
| AltSymbols =; SEP2; KIAA0202
| OMIM = 608418
| ECnumber = 
| Homologene = 
| MGIid = 
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23176
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_034872
    | Hs_RefseqmRNA = XM_034872
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Septin 8''', also known as '''SEPT8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEPT8 septin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23176| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SEPT8 is a member of the highly conserved [[septin]] family. Septins are 40- to 60-kD [[GTPase]]s that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking (Blaser et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SEPT8 septin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23176| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SEPT8 has been shown to [[Protein-protein interaction|interact]] with [[PFTK1]]<ref name = pmid12098780>{{cite journal | vauthors = Yang T, Gao YK, Chen JY | title = KIAA0202, a human septin family member, interacting with hPFTAIRE1 | journal = Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica | volume = 34 | issue = 4 | pages = 520–5 | date = July 2002 | pmid = 12098780 | doi =  }}</ref> and [[SEPT5]].<ref name = pmid12909369>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}</ref><ref name = pmid12023038>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ | title = Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11 | journal = Genomics | volume = 63 | issue = 3 | pages = 354–73 | date = February 2000 | pmid = 10704283 | doi = 10.1006/geno.1999.6100 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}
*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi=  }}
* {{cite journal | vauthors = Yang T, Gao YK, Chen JY | title = KIAA0202, a human septin family member, interacting with hPFTAIRE1 | journal = Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica | volume = 34 | issue = 4 | pages = 520–5 | date = July 2002 | pmid = 12098780 | doi =  }}
*{{cite journal  | author=Frazer KA, Ueda Y, Zhu Y, ''et al.'' |title=Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. |journal=Genome Res. |volume=7 |issue= 5 |pages= 495-512 |year= 1997 |pmid= 9149945 |doi=  }}
* {{cite journal | vauthors = Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B|authorlink7=Mary B. Kennedy | title = Mammalian septins nomenclature | journal = Molecular Biology of the Cell | volume = 13 | issue = 12 | pages = 4111–3 | date = December 2002 | pmid = 12475938 | pmc = 138619 | doi = 10.1091/mbc.E02-07-0438 }}
*{{cite journal | author=Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ |title=Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11. |journal=Genomics |volume=63 |issue= 3 |pages= 354-73 |year= 2000 |pmid= 10704283 |doi= 10.1006/geno.1999.6100 }}
* {{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}
*{{cite journal | author=Bläser S, Jersch K, Hainmann I, ''et al.'' |title=Human septin-septin interaction: CDCrel-1 partners with KIAA0202. |journal=FEBS Lett. |volume=519 |issue= 1-3 |pages= 169-72 |year= 2002 |pmid= 12023038 |doi= }}
* {{cite journal | vauthors = Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B | title = The novel human platelet septin SEPT8 is an interaction partner of SEPT4 | journal = Thrombosis and Haemostasis | volume = 91 | issue = 5 | pages = 959–66 | date = May 2004 | pmid = 15116257 | doi = 10.1160/TH03-09-0578 }}
*{{cite journal | author=Yang T, Gao YK, Chen JY |title=KIAA0202, a human septin family member, interacting with hPFTAIRE1. |journal=Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao |volume=34 |issue= 4 |pages= 520-5 |year= 2002 |pmid= 12098780 |doi=  }}
* {{cite journal | vauthors = Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J | title = Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol | journal = The Biochemical Journal | volume = 382 | issue = Pt 3 | pages = 783–91 | date = September 2004 | pmid = 15214843 | pmc = 1133953 | doi = 10.1042/BJ20040372 }}
*{{cite journal | author=Macara IG, Baldarelli R, Field CM, ''et al.'' |title=Mammalian septins nomenclature. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4111-3 |year= 2003 |pmid= 12475938 |doi= 10.1091/mbc.E02-07-0438 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B | title = Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5 | journal = The Journal of Pathology | volume = 210 | issue = 1 | pages = 103–10 | date = September 2006 | pmid = 16767699 | doi = 10.1002/path.2013 }}
*{{cite journal  | author=Bläser S, Jersch K, Hainmann I, ''et al.'' |title=Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202). |journal=Gene |volume=312 |issue=  |pages= 313-20 |year= 2003 |pmid= 12909369 |doi= }}
* {{cite journal | vauthors = Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P | title = Septin expression in proliferative retinal membranes | journal = The Journal of Histochemistry and Cytochemistry | volume = 55 | issue = 11 | pages = 1089–94 | date = November 2007 | pmid = 17625225 | doi = 10.1369/jhc.7A7188.2007 | pmc = 3957527 }}
*{{cite journal | author=Bläser S, Horn J, Würmell P, ''et al.'' |title=The novel human platelet septin SEPT8 is an interaction partner of SEPT4. |journal=Thromb. Haemost. |volume=91 |issue= 5 |pages= 959-66 |year= 2004 |pmid= 15116257 |doi= 10.1267/THRO04050959 }}
*{{cite journal | author=Martínez C, Sanjuan MA, Dent JA, ''et al.'' |title=Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. |journal=Biochem. J. |volume=382 |issue= Pt 3 |pages= 783-91 |year= 2005 |pmid= 15214843 |doi= 10.1042/BJ20040372 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Bläser S, Röseler S, Rempp H, ''et al.'' |title=Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5. |journal=J. Pathol. |volume=210 |issue= 1 |pages= 103-10 |year= 2006 |pmid= 16767699 |doi= 10.1002/path.2013 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Xin X, Pache M, Zieger B, ''et al.'' |title=Septin expression in proliferative retinal membranes. |journal=J. Histochem. Cytochem. |volume=55 |issue= 11 |pages= 1089-94 |year= 2007 |pmid= 17625225 |doi= 10.1369/jhc.7A7188.2007 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 10:01, 16 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.[1][2][3]

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.[3]

Interactions

SEPT8 has been shown to interact with PFTK1[4] and SEPT5.[5][6]

References

  1. ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  2. ↑ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.
  3. ↑ 3.0 3.1 "Entrez Gene: SEPT8 septin 8".
  4. ↑ Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
  5. ↑ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
  6. ↑ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038.

Further reading

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