Sjögren syndrome antigen B: Difference between revisions

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Sjögren syndrome antigen B has been shown to [[Protein-protein interaction|interact]] with [[nucleolin]].<ref name=pmid12096904>{{cite journal | vauthors = Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ | title = Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes | journal = Journal of Molecular Biology | volume = 320 | issue = 3 | pages = 475–88 | date = July 2002 | pmid = 12096904 | doi = 10.1016/S0022-2836(02)00518-1 }}</ref>
Sjögren syndrome antigen B has been shown to [[Protein-protein interaction|interact]] with [[nucleolin]].<ref name=pmid12096904>{{cite journal | vauthors = Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ | title = Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes | journal = Journal of Molecular Biology | volume = 320 | issue = 3 | pages = 475–88 | date = July 2002 | pmid = 12096904 | doi = 10.1016/S0022-2836(02)00518-1 }}</ref>
== See also ==
* [[La domain]]


== References ==
== References ==

Latest revision as of 09:20, 25 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.[1]

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.[1][2]

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.[3]

See also


References

  1. 1.0 1.1 "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)".
  2. Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Molecular Cell. 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMID 16387655.
  3. Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.

Further reading