HEXIM1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein HEXIM1''' is a [[protein]] that in humans is encoded by the ''HEXIM1'' [[gene]].<ref name="pmid12119119">{{cite journal | vauthors = Huang F, Wagner M, Siddiqui MA | title = Structure, expression, and functional characterization of the mouse CLP-1 gene | journal = Gene | volume = 292 | issue = 1–2 | pages = 245–59 | date = Jul 2002 | pmid = 12119119 | pmc =  | doi = 10.1016/S0378-1119(02)00596-6 }}</ref><ref name="pmid12832472">{{cite journal | vauthors = Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O | title = MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner | journal = Mol Cell Biol | volume = 23 | issue = 14 | pages = 4859–69 | date = Jun 2003 | pmid = 12832472 | pmc = 162212 | doi = 10.1128/MCB.23.14.4859-4869.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10614| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Hexamethylene bis-acetamide inducible 1
| HGNCid = 24953
| Symbol = HEXIM1
| AltSymbols =; EDG1; HIS1; CLP1; FLJ13562; MAQ1
| OMIM = 607328
| ECnumber = 
| Homologene = 31382
| MGIid = 2385923
| GeneAtlas_image1 = PBB_GE_HEXIM1_202814_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HEXIM1_202815_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0017069 |text = snRNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10614
    | Hs_Ensembl = ENSG00000186834
    | Hs_RefseqProtein = NP_006451
    | Hs_RefseqmRNA = NM_006460
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 40580467
    | Hs_GenLoc_end = 40585251
    | Hs_Uniprot = 
    | Mm_EntrezGene = 192231
    | Mm_Ensembl = ENSMUSG00000048878
    | Mm_RefseqmRNA = NM_138753
    | Mm_RefseqProtein = NP_620092
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102932415
    | Mm_GenLoc_end = 102935815
    | Mm_Uniprot = 
  }}
}}
'''Hexamethylene bis-acetamide inducible 1''', also known as '''HEXIM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10614| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
HEXIM1 has been shown to [[Protein-protein interaction|interact]] with [[Cyclin T1]]<ref name=pmid12832472 /> and [[Cdk9]]<ref name="pmid27791144">{{cite journal | vauthors = Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O | title = An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb | journal = Proc Natl Acad Sci U S A | volume = 113 | issue = 45 | pages = 12721-6 | date = October 2016 | pmid =     27791144 | doi = 10.1073/pnas.1612331113}}</ref>
{{PBB_Summary
| section_title =  
| summary_text = Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.<ref name="entrez">{{cite web | title = Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10614| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 7 | pages = 3491–6 | year = 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491}}
| citations =
*{{cite journal | vauthors = Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H | title = Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells | journal = Genes Cells | volume = 8 | issue = 2 | pages = 95–107 | year = 2003 | pmid = 12581153 | doi = 10.1046/j.1365-2443.2003.00618.x}}
*{{cite journal | author=Wolff A |title=[Problem of occupational disability hazards] |journal=Lebensversicherungs Medizin |volume=28 |issue= 3 |pages= 76-7 |year= 1976 |pmid= 9544 |doi=  }}
*{{cite journal | vauthors = Wittmann BM, Wang N, Montano MM | title = Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors | journal = Cancer Res. | volume = 63 | issue = 16 | pages = 5151–8 | year = 2003 | pmid = 12941847}}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal | vauthors = Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q | title = Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA | journal = Mol. Cell | volume = 12 | issue = 4 | pages = 971–82 | year = 2003 | pmid = 14580347 | doi = 10.1016/S1097-2765(03)00388-5}}
*{{cite journal | author=Huang F, Wagner M, Siddiqui MA |title=Structure, expression, and functional characterization of the mouse CLP-1 gene. |journal=Gene |volume=292 |issue= 1-2 |pages= 245-59 |year= 2002 |pmid= 12119119 |doi= }}
*{{cite journal | vauthors = Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR | title = Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation | journal = Cell | volume = 117 | issue = 3 | pages = 311–21 | year = 2004 | pmid = 15109492 | doi = 10.1016/S0092-8674(04)00342-3}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q | title = A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb | journal = Mol. Cell. Biol. | volume = 24 | issue = 12 | pages = 5094–105 | year = 2004 | pmid = 15169877 | pmc = 419863 | doi = 10.1128/MCB.24.12.5094-5105.2004}}
*{{cite journal | author=Ouchida R, Kusuhara M, Shimizu N, ''et al.'' |title=Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. |journal=Genes Cells |volume=8 |issue= 2 |pages= 95-107 |year= 2003 |pmid= 12581153 |doi= }}
*{{cite journal | vauthors = Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O | title = Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor | journal = EMBO J. | volume = 23 | issue = 13 | pages = 2608–19 | year = 2005 | pmid = 15201869 | pmc = 449783 | doi = 10.1038/sj.emboj.7600275}}
*{{cite journal | author=Michels AA, Nguyen VT, Fraldi A, ''et al.'' |title=MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. |journal=Mol. Cell. Biol. |volume=23 |issue= 14 |pages= 4859-69 |year= 2003 |pmid= 12832472 |doi= }}
*{{cite journal | vauthors = Yik JH, Chen R, Pezda AC, Zhou Q | title = Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription | journal = J. Biol. Chem. | volume = 280 | issue = 16 | pages = 16368–76 | year = 2005 | pmid = 15713661 | doi = 10.1074/jbc.M500912200 }}
*{{cite journal | author=Yik JH, Chen R, Nishimura R, ''et al.'' |title=Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. |journal=Mol. Cell |volume=12 |issue= 4 |pages= 971-82 |year= 2003 |pmid= 14580347 |doi= }}
*{{cite journal | vauthors = Byers SA, Price JP, Cooper JJ, Li Q, Price DH | title = HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK | journal = J. Biol. Chem. | volume = 280 | issue = 16 | pages = 16360–7 | year = 2005 | pmid = 15713662 | doi = 10.1074/jbc.M500424200}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | vauthors = Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blazek D, Peterlin BM, Geyer M | title = Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat | journal = J. Biol. Chem. | volume = 280 | issue = 26 | pages = 24968–77 | year = 2005 | pmid = 15855166 | doi = 10.1074/jbc.M501431200}}
*{{cite journal  | author=Paushkin SV, Patel M, Furia BS, ''et al.'' |title=Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. |journal=Cell |volume=117 |issue= 3 |pages= 311-21 |year= 2004 |pmid= 15109492 |doi= }}
*{{cite journal | vauthors = Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM | title = The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1 | journal = Oncogene | volume = 24 | issue = 36 | pages = 5576–88 | year = 2005 | pmid = 15940264 | doi = 10.1038/sj.onc.1208728}}
*{{cite journal | author=Yik JH, Chen R, Pezda AC, ''et al.'' |title=A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5094-105 |year= 2004 |pmid= 15169877 |doi= 10.1128/MCB.24.12.5094-5105.2004 }}
*{{cite journal | vauthors = Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H | title = HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 24 | pages = 8555–60 | year = 2005 | pmid = 15941832 | pmc = 1150813 | doi = 10.1073/pnas.0409863102}}
*{{cite journal | author=Michels AA, Fraldi A, Li Q, ''et al.'' |title=Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. |journal=EMBO J. |volume=23 |issue= 13 |pages= 2608-19 |year= 2005 |pmid= 15201869 |doi= 10.1038/sj.emboj.7600275 }}
*{{cite journal | vauthors = Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH | title = Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186 | journal = J. Biol. Chem. | volume = 280 | issue = 31 | pages = 28819–26 | year = 2005 | pmid = 15965233 | doi = 10.1074/jbc.M502712200}}
*{{cite journal | author=Yik JH, Chen R, Pezda AC, Zhou Q |title=Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 16368-76 |year= 2005 |pmid= 15713661 |doi= 10.1074/jbc.M500912200 }}
*{{cite journal | vauthors = Fraldi A, Varrone F, Napolitano G, Michels AA, Majello B, Bensaude O, Lania L | title = Inhibition of Tat activity by the HEXIM1 protein | journal = Retrovirology | volume = 2 | issue = | pages = 42 | year = 2006 | pmid = 15992410 | pmc = 1183248 | doi = 10.1186/1742-4690-2-42}}
*{{cite journal | author=Byers SA, Price JP, Cooper JJ, ''et al.'' |title=HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 16360-7 |year= 2005 |pmid= 15713662 |doi= 10.1074/jbc.M500424200 }}
*{{cite journal | vauthors = Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O | title = Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer | journal = J. Biol. Chem. | volume = 280 | issue = 34 | pages = 30619–29 | year = 2005 | pmid = 15994294 | doi = 10.1074/jbc.M502471200}}
*{{cite journal | author=Schulte A, Czudnochowski N, Barboric M, ''et al.'' |title=Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24968-77 |year= 2005 |pmid= 15855166 |doi= 10.1074/jbc.M501431200 }}
*{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209}}
*{{cite journal | author=Wittmann BM, Fujinaga K, Deng H, ''et al.'' |title=The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. |journal=Oncogene |volume=24 |issue= 36 |pages= 5576-88 |year= 2005 |pmid= 15940264 |doi= 10.1038/sj.onc.1208728 }}
*{{cite journal | author=Shimizu N, Ouchida R, Yoshikawa N, ''et al.'' |title=HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 24 |pages= 8555-60 |year= 2005 |pmid= 15941832 |doi= 10.1073/pnas.0409863102 }}
*{{cite journal | author=Li Q, Price JP, Byers SA, ''et al.'' |title=Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28819-26 |year= 2005 |pmid= 15965233 |doi= 10.1074/jbc.M502712200 }}
*{{cite journal  | author=Fraldi A, Varrone F, Napolitano G, ''et al.'' |title=Inhibition of Tat activity by the HEXIM1 protein. |journal=Retrovirology |volume=2 |issue=  |pages= 42 |year= 2006 |pmid= 15992410 |doi= 10.1186/1742-4690-2-42 }}
*{{cite journal  | author=Dulac C, Michels AA, Fraldi A, ''et al.'' |title=Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. |journal=J. Biol. Chem. |volume=280 |issue= 34 |pages= 30619-29 |year= 2005 |pmid= 15994294 |doi= 10.1074/jbc.M502471200 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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Latest revision as of 15:35, 20 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.[1][2][3]

Interactions

HEXIM1 has been shown to interact with Cyclin T1[2] and Cdk9[4]

References

  1. ↑ Huang F, Wagner M, Siddiqui MA (Jul 2002). "Structure, expression, and functional characterization of the mouse CLP-1 gene". Gene. 292 (1–2): 245–59. doi:10.1016/S0378-1119(02)00596-6. PMID 12119119.
  2. ↑ 2.0 2.1 Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
  3. ↑ "Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1".
  4. ↑ Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O (October 2016). "An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb". Proc Natl Acad Sci U S A. 113 (45): 12721–6. doi:10.1073/pnas.1612331113. PMID 27791144.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=HEXIM1&oldid=1529168"