PON3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Paraoxonase 3''', also known as '''PON3''', is a [[protein]] which in humans is encoded by the ''PON3'' [[gene]].<ref name="pmid8661009">{{cite journal | vauthors = Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN | title = The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family | journal = Genomics | volume = 33 | issue = 3 | pages = 498–507 |date=May 1996 | pmid = 8661009 | doi = 10.1006/geno.1996.0225| url = | issn = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PON3 paraoxonase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Paraoxonase 3
| HGNCid = 9206
| Symbol = PON3
| AltSymbols =;
| OMIM = 602720
| ECnumber = 
| Homologene = 37371
| MGIid = 106686
| GeneAtlas_image1 = PBB_GE_PON3_213695_at_tn.png
| Function = {{GNF_GO|id=GO:0004064 |text = arylesterase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0009605 |text = response to external stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5446
    | Hs_Ensembl = ENSG00000105852
    | Hs_RefseqProtein = NP_000931
    | Hs_RefseqmRNA = NM_000940
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 94827209
    | Hs_GenLoc_end = 94863609
    | Hs_Uniprot = Q15166
    | Mm_EntrezGene = 269823
    | Mm_Ensembl = ENSMUSG00000029759
    | Mm_RefseqmRNA = NM_173006
    | Mm_RefseqProtein = NP_766594
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 5170852
    | Mm_GenLoc_end = 5206233
    | Mm_Uniprot = Q4FZK0
  }}
}}
'''[[Paraoxonase]] 3''', also known as '''PON3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PON3 paraoxonase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[paraoxonase]] family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein ([[high-density lipoprotein|HDL]]). The protein also rapidly hydrolyzes [[lactone]]s and can inhibit the oxidation of low-density lipoprotein ([[low-density lipoprotein|LDL]]), a function that is believed to slow the initiation and progression of [[atherosclerosis]]. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.<ref name="entrez">{{cite web | title = Entrez Gene: PON3 paraoxonase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Mackness B, Durrington PN, Mackness MI |title=The paraoxonase gene family and coronary heart disease. |journal=Curr. Opin. Lipidol. |volume=13 |issue= 4 |pages= 357–62 |year= 2003 |pmid= 12151850 |doi=10.1097/00041433-200208000-00002 }}
| citations =
*{{cite journal   |vauthors=Ng CJ, Shih DM, Hama SY, etal |title=The paraoxonase gene family and atherosclerosis. |journal=Free Radic. Biol. Med. |volume=38 |issue= 2 |pages= 153–63 |year= 2005 |pmid= 15607899 |doi= 10.1016/j.freeradbiomed.2004.09.035 }}
*{{cite journal  | author=Mackness B, Durrington PN, Mackness MI |title=The paraoxonase gene family and coronary heart disease. |journal=Curr. Opin. Lipidol. |volume=13 |issue= 4 |pages= 357-62 |year= 2003 |pmid= 12151850 |doi=  }}
*{{cite journal  | vauthors=Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN |title=The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. |journal=Genomics |volume=33 |issue= 3 |pages= 498–507 |year= 1996 |pmid= 8661009 |doi=10.1006/geno.1996.0225 }}
*{{cite journal | author=Ng CJ, Shih DM, Hama SY, ''et al.'' |title=The paraoxonase gene family and atherosclerosis. |journal=Free Radic. Biol. Med. |volume=38 |issue= 2 |pages= 153-63 |year= 2005 |pmid= 15607899 |doi= 10.1016/j.freeradbiomed.2004.09.035 }}
*{{cite journal  | author=La Du BN |title=Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis? |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 467–8 |year= 2001 |pmid= 11304457 |doi=  10.1161/01.ATV.21.4.467}}
*{{cite journal  | author=Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN |title=The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. |journal=Genomics |volume=33 |issue= 3 |pages= 498-507 |year= 1996 |pmid= 8661009 |doi=  }}
*{{cite journal   |vauthors=Reddy ST, Wadleigh DJ, Grijalva V, etal |title=Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 542–7 |year= 2001 |pmid= 11304470 |doi=  10.1161/01.ATV.21.4.542}}
*{{cite journal  | author=La Du BN |title=Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis? |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 467-8 |year= 2001 |pmid= 11304457 |doi=  }}
*{{cite journal   |vauthors=Xu XR, Huang J, Xu ZG, etal |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 | pmc=64988 }}
*{{cite journal | author=Reddy ST, Wadleigh DJ, Grijalva V, ''et al.'' |title=Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 542-7 |year= 2001 |pmid= 11304470 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Xu XR, Huang J, Xu ZG, ''et al.'' |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089-94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Aharoni A, Gaidukov L, Yagur S, etal |title=Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 2 |pages= 482–7 |year= 2004 |pmid= 14695884 |doi= 10.1073/pnas.2536901100 | pmc=327173 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Aharoni A, Gaidukov L, Yagur S, ''et al.'' |title=Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 2 |pages= 482-7 |year= 2004 |pmid= 14695884 |doi= 10.1073/pnas.2536901100 }}
*{{cite journal   |vauthors=Jin P, Fu GK, Wilson AD, etal |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Jin P, Fu GK, Wilson AD, ''et al.'' |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566-71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 }}
*{{cite journal   |vauthors=Draganov DI, Teiber JF, Speelman A, etal |title=Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. |journal=J. Lipid Res. |volume=46 |issue= 6 |pages= 1239–47 |year= 2005 |pmid= 15772423 |doi= 10.1194/jlr.M400511-JLR200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Shamir R, Hartman C, Karry R, etal |title=Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2. |journal=Free Radic. Biol. Med. |volume=39 |issue= 3 |pages= 336–44 |year= 2005 |pmid= 15993332 |doi= 10.1016/j.freeradbiomed.2005.03.016 }}
*{{cite journal | author=Draganov DI, Teiber JF, Speelman A, ''et al.'' |title=Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. |journal=J. Lipid Res. |volume=46 |issue= 6 |pages= 1239-47 |year= 2005 |pmid= 15772423 |doi= 10.1194/jlr.M400511-JLR200 }}
*{{cite journal   |vauthors=Lu H, Zhu J, Zang Y, etal |title=Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product. |journal=Biochem. Pharmacol. |volume=70 |issue= 7 |pages= 1019–25 |year= 2005 |pmid= 16099434 |doi= 10.1016/j.bcp.2005.07.004 }}
*{{cite journal | author=Shamir R, Hartman C, Karry R, ''et al.'' |title=Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2. |journal=Free Radic. Biol. Med. |volume=39 |issue= 3 |pages= 336-44 |year= 2005 |pmid= 15993332 |doi= 10.1016/j.freeradbiomed.2005.03.016 }}
*{{cite journal   |vauthors=Lu H, Zhu J, Zang Y, etal |title=Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization. |journal=Protein Expr. Purif. |volume=46 |issue= 1 |pages= 92–9 |year= 2006 |pmid= 16139510 |doi= 10.1016/j.pep.2005.07.021 }}
*{{cite journal | author=Lu H, Zhu J, Zang Y, ''et al.'' |title=Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product. |journal=Biochem. Pharmacol. |volume=70 |issue= 7 |pages= 1019-25 |year= 2005 |pmid= 16099434 |doi= 10.1016/j.bcp.2005.07.004 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Lu H, Zhu J, Zang Y, ''et al.'' |title=Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization. |journal=Protein Expr. Purif. |volume=46 |issue= 1 |pages= 92-9 |year= 2006 |pmid= 16139510 |doi= 10.1016/j.pep.2005.07.021 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
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Latest revision as of 18:27, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.[1][2]

Function

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[2]

References

  1. ↑ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
  2. ↑ 2.0 2.1 "Entrez Gene: PON3 paraoxonase 3".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=PON3&oldid=1421572"