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{{Infobox_gene}}
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'''Proto-oncogene protein Wnt-3''' is a [[protein]] that in humans is encoded by the ''WNT3'' [[gene]].<ref name="pmid8244403">{{cite journal |vauthors=Roelink H, Wang J, Black DM, Solomon E, Nusse R | title = Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene | journal = Genomics | volume = 17 | issue = 3 | pages = 790–2 |date=Dec 1993 | pmid = 8244403 | pmc =  | doi = 10.1006/geno.1993.1412 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7473| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Wingless-type MMTV integration site family, member 3
| HGNCid = 12782
| Symbol = WNT3
| AltSymbols =; INT4; MGC131950; MGC138321; MGC138323
| OMIM = 165330
| ECnumber = 
| Homologene = 22527
| MGIid = 98955
| GeneAtlas_image1 = PBB_GE_WNT3_221455_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0007223 |text = Wnt receptor signaling pathway, calcium modulating pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7473
    | Hs_Ensembl = ENSG00000108379
    | Hs_RefseqProtein = NP_110380
    | Hs_RefseqmRNA = NM_030753
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 42196863
    | Hs_GenLoc_end = 42251081
    | Hs_Uniprot = P56703
    | Mm_EntrezGene = 22415
    | Mm_Ensembl = ENSMUSG00000000125
    | Mm_RefseqmRNA = NM_009521
    | Mm_RefseqProtein = NP_033547
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 103590314
    | Mm_GenLoc_end = 103634047
    | Mm_Uniprot = Q3TQ59
  }}
}}
'''Wingless-type MMTV integration site family, member 3''', also known as '''WNT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7473| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.<ref name="entrez">{{cite web | title = Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7473| accessdate = }}</ref>
| summary_text = The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the [[Wnt signalling pathway#The canonical Wnt pathway|WNT-beta-catenin-TCF signaling pathway]]. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=tetra-amelia  GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome]
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nusse R, Brown A, Papkoff J, ''et al.'' |title=A new nomenclature for int-1 and related genes: the Wnt gene family. |journal=Cell |volume=64 |issue= 2 |pages= 231 |year= 1991 |pmid= 1846319 |doi=  }}
*{{cite journal  | author=Nusse R |title=A new nomenclature for int-1 and related genes: the Wnt gene family |journal=Cell |volume=64 |issue= 2 |pages= 231 |year= 1991 |pmid= 1846319 |doi=10.1016/0092-8674(91)90633-A  |name-list-format=vanc| author2=Brown A  | author3=Papkoff J  | display-authors=3  | last4=Scambler  | first4=P  | last5=Shackleford  | first5=G  | last6=McMahon  | first6=A  | last7=Moon  | first7=R  | last8=Varmus  | first8=H }}
*{{cite journal  | author=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface. |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267-75 |year= 1994 |pmid= 8167409 |doi=  }}
*{{cite journal  |vauthors=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi=  10.1091/mbc.4.12.1267| pmc=275763  }}
*{{cite journal  | author=Roelink H, Wang J, Black DM, ''et al.'' |title=Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. |journal=Genomics |volume=17 |issue= 3 |pages= 790-2 |year= 1993 |pmid= 8244403 |doi= 10.1006/geno.1993.1412 }}
*{{cite journal  | author=Liu P |title=Requirement for Wnt3 in vertebrate axis formation |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 361–5 |year= 1999 |pmid= 10431240 |doi= 10.1038/11932 |name-list-format=vanc| author2=Wakamiya M  | author3=Shea MJ  | display-authors=3  | last4=Wakamiya  | first4=Maki  | last5=Shea  | first5=Martin J.  | last6=Albrecht  | first6=Urs }}
*{{cite journal  | author=Liu P, Wakamiya M, Shea MJ, ''et al.'' |title=Requirement for Wnt3 in vertebrate axis formation. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 361-5 |year= 1999 |pmid= 10431240 |doi= 10.1038/11932 }}
*{{cite journal  | author=Gazit A |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response |journal=Oncogene |volume=18 |issue= 44 |pages= 5959–66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985 |name-list-format=vanc| author2=Yaniv A  | author3=Bafico A  | display-authors=3  | last4=Pramila  | first4=Tata  | last5=Igarashi  | first5=Makoto  | last6=Kitajewski  | first6=Jan  | last7=Aaronson  | first7=Stuart A }}
*{{cite journal  | author=Gazit A, Yaniv A, Bafico A, ''et al.'' |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. |journal=Oncogene |volume=18 |issue= 44 |pages= 5959-66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Katoh M |title=Molecular cloning and characterization of human WNT3 |journal=Int. J. Oncol. |volume=19 |issue= 5 |pages= 977–82 |year= 2002 |pmid= 11604997 |doi=  10.3892/ijo.19.5.977}}
*{{cite journal  | author=Katoh M |title=Molecular cloning and characterization of human WNT3. |journal=Int. J. Oncol. |volume=19 |issue= 5 |pages= 977-82 |year= 2002 |pmid= 11604997 |doi=  }}
*{{cite journal  | author=Katoh M |title=Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45 |journal=Int. J. Oncol. |volume=20 |issue= 2 |pages= 373–7 |year= 2002 |pmid= 11788904 |doi=  10.3892/ijo.20.2.373}}
*{{cite journal  | author=Katoh M |title=Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. |journal=Int. J. Oncol. |volume=20 |issue= 2 |pages= 373-7 |year= 2002 |pmid= 11788904 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Niemann S |title=Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 558–63 |year= 2004 |pmid= 14872406 |doi= 10.1086/382196 | pmc=1182269  |name-list-format=vanc| author2=Zhao C  | author3=Pascu F  | display-authors=3  | last4=Stahl  | first4=U  | last5=Aulepp  | first5=U  | last6=Niswander  | first6=L  | last7=Weber  | first7=J  | last8=Muller  | first8=U }}
*{{cite journal  | author=Niemann S, Zhao C, Pascu F, ''et al.'' |title=Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 558-63 |year= 2004 |pmid= 14872406 |doi= 10.1086/382196 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chiba H |title=Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells |journal=Exp. Hematol. |volume=32 |issue= 12 |pages= 1194–203 |year= 2005 |pmid= 15588944 |doi= 10.1016/j.exphem.2004.08.010 |name-list-format=vanc| author2=Kobune M  | author3=Kato J  | display-authors=3  | last4=Kawano  | first4=Yutaka  | last5=Ito  | first5=Yoshinori  | last6=Nakamura  | first6=Kiminori  | last7=Asakura  | first7=Sumiyo  | last8=Hamada  | first8=Hirofumi  | last9=Niitsu  | first9=Yoshiro }}
*{{cite journal  | author=Chiba H, Kobune M, Kato J, ''et al.'' |title=Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. |journal=Exp. Hematol. |volume=32 |issue= 12 |pages= 1194-203 |year= 2005 |pmid= 15588944 |doi= 10.1016/j.exphem.2004.08.010 }}
*{{cite journal  |vauthors=Yamamoto H, Komekado H, Kikuchi A |title=Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin |journal=Dev. Cell |volume=11 |issue= 2 |pages= 213–23 |year= 2006 |pmid= 16890161 |doi= 10.1016/j.devcel.2006.07.003 }}
*{{cite journal  | author=Yamamoto H, Komekado H, Kikuchi A |title=Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. |journal=Dev. Cell |volume=11 |issue= 2 |pages= 213-23 |year= 2006 |pmid= 16890161 |doi= 10.1016/j.devcel.2006.07.003 }}
}}
}}
{{refend}}
{{refend}}


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{{Wnt signaling pathway}}
 
 
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Latest revision as of 22:45, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[2]

References

  1. ↑ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
  2. ↑ 2.0 2.1 "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

Further reading



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