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{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(o) subunit alpha''' is a [[protein]] that in humans is encoded by the ''GNAO1'' [[gene]].<ref name="pmid1899283">{{cite journal |author1=Murtagh JJ Jr |author2=Eddy R |author3=Shows TB |author4=Moss J |author5=Vaughan M | title = Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16 | journal = Mol Cell Biol | volume = 11 | issue = 2 | pages = 1146–55 |date=Mar 1991 | pmid = 1899283 | pmc = 359797 | doi =  }}</ref><ref name="pmid11395521">{{cite journal |vauthors=Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S | title = Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels | journal = J Biol Chem | volume = 276 | issue = 31 | pages = 28731–8 |date=Jul 2001 | pmid = 11395521 | pmc =  | doi = 10.1074/jbc.M104806200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2775| accessdate = }}</ref>
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mutations in this gene have been shown to cause [[epileptic encephalopathy]].<ref name="pmid23993195">{{cite journal |vauthors=Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H | title = De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy | journal = Am. J. Hum. Genet. | volume = 93 | issue = 3 | pages = 496–505 |date=September 2013 | pmid = 23993195 | doi = 10.1016/j.ajhg.2013.07.014 | pmc=3769919}}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
| HGNCid = 4389
| Symbol = GNAO1
| AltSymbols =; DKFZp686O0962; G-ALPHA-o; GNAO
| OMIM = 139311
| ECnumber = 
| Homologene = 39203
| MGIid = 95775
| GeneAtlas_image1 = PBB_GE_GNAO1_204762_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNAO1_204763_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNAO1_215912_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007212 |text = dopamine receptor signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2775
    | Hs_Ensembl = ENSG00000087258
    | Hs_RefseqProtein = NP_066268
    | Hs_RefseqmRNA = NM_020988
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 54783389
    | Hs_GenLoc_end = 54948651
    | Hs_Uniprot = P09471
    | Mm_EntrezGene = 14681
    | Mm_Ensembl = ENSMUSG00000031748
    | Mm_RefseqmRNA = NM_010308
    | Mm_RefseqProtein = NP_034438
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 96699967
    | Mm_GenLoc_end = 96858351
    | Mm_Uniprot = Q543S2
  }}
}}
'''Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O''', also known as '''GNAO1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2775| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
GNAO1 has been shown to [[Protein-protein interaction|interact]] with:
| section_title =  
* [[RGS5]],<ref name = pmid9079700>{{cite journal |vauthors=Chen C, Zheng B, Han J, Lin SC | title = Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast | journal = J. Biol. Chem. | volume = 272 | issue = 13 | pages = 8679–85 | year = 1997 | pmid = 9079700 | doi = 10.1074/jbc.272.13.8679}}</ref><ref name = pmid11253162>{{cite journal |vauthors=Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S | title = Characterization of RGS5 in regulation of G protein-coupled receptor signaling | journal = Life Sci. | volume = 68 | issue = 13 | pages = 1457–69 | year = 2001 | pmid = 11253162 | doi = 10.1016/S0024-3205(01)00939-0}}</ref>
| summary_text =  
* [[RGS19]],<ref name = pmid8986788>{{cite journal |vauthors=De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 26 | pages = 15203–8 | year = 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203}}</ref><ref name = pmid10364213>{{cite journal |vauthors=Woulfe DS, Stadel JM | title = Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP | journal = J. Biol. Chem. | volume = 274 | issue = 25 | pages = 17718–24 | year = 1999 | pmid = 10364213 | doi = 10.1074/jbc.274.25.17718}}</ref>
}}
* [[RGS20]],<ref name = pmid18407463>{{cite journal |vauthors=Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R | title = Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways | journal = Cell. Signal. | volume = 20 | issue = 6 | pages = 1190–7 | year = 2008 | pmid = 18407463 | pmc = 3107604 | doi = 10.1016/j.cellsig.2008.02.008 }}</ref> and
* [[RIC8A]]<ref name = pmid12509430>{{cite journal |vauthors=Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8356–62 | year = 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Raymond JR, Mukhin YV, Gelasco A |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2–3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=10.1016/S0163-7258(01)00169-3 |display-authors=etal}}
| citations =
*{{cite journal  |vauthors=Coupry I, Duzic E, Lanier SM |title=Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9852–7 |year= 1992 |pmid= 1349607 |doi=  }}
*{{cite journal  | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi=  }}
*{{cite journal  |vauthors=Denker BM, Neer EJ, Schmidt CJ |title=Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6272–7 |year= 1992 |pmid= 1556134 |doi=  }}
*{{cite journal  | author=Coupry I, Duzic E, Lanier SM |title=Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9852-7 |year= 1992 |pmid= 1349607 |doi=  }}
*{{cite journal  |vauthors=Yi F, Denker BM, Neer EJ |title=Structural and functional studies of cross-linked Go protein subunits. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3900–6 |year= 1991 |pmid= 1899868 |doi=  }}
*{{cite journal  | author=Denker BM, Neer EJ, Schmidt CJ |title=Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6272-7 |year= 1992 |pmid= 1556134 |doi=  }}
*{{cite journal  |vauthors=Tsukamoto T, Toyama R, Itoh H |title=Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 8 |pages= 2974–8 |year= 1991 |pmid= 1901650 |doi=10.1073/pnas.88.8.2974 | pmc=51366  |display-authors=etal}}
*{{cite journal  | author=Murtagh JJ, Eddy R, Shows TB, ''et al.'' |title=Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16. |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1146-55 |year= 1991 |pmid= 1899283 |doi=  }}
*{{cite journal  |vauthors=Gabrion J, Brabet P, Nguyen Than Dao B |title=Ultrastructural localization of the GTP-binding protein Go in neurons. |journal=Cell. Signal. |volume=1 |issue= 1 |pages= 107–23 |year= 1990 |pmid= 2518353 |doi=10.1016/0898-6568(89)90025-9 |display-authors=etal}}
*{{cite journal  | author=Yi F, Denker BM, Neer EJ |title=Structural and functional studies of cross-linked Go protein subunits. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3900-6 |year= 1991 |pmid= 1899868 |doi=  }}
*{{cite journal  |vauthors=Lavu S, Clark J, Swarup R |title=Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 2 |pages= 811–5 |year= 1988 |pmid= 3124840 |doi=10.1016/0006-291X(88)90463-9  |display-authors=etal}}
*{{cite journal  | author=Tsukamoto T, Toyama R, Itoh H, ''et al.'' |title=Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 8 |pages= 2974-8 |year= 1991 |pmid= 1901650 |doi=  }}
*{{cite journal  |vauthors=Zumbihl R, Breuiller-Fouché M, Carrette J |title=Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. |journal=Eur. J. Pharmacol. |volume=288 |issue= 1 |pages= 9–15 |year= 1995 |pmid= 7705473 |doi=  10.1016/0922-4106(94)90004-3|display-authors=etal}}
*{{cite journal  | author=Gabrion J, Brabet P, Nguyen Than Dao B, ''et al.'' |title=Ultrastructural localization of the GTP-binding protein Go in neurons. |journal=Cell. Signal. |volume=1 |issue= 1 |pages= 107-23 |year= 1990 |pmid= 2518353 |doi= }}
*{{cite journal  |vauthors=Grassie MA, Milligan G |title=Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. |journal=Biochem. J. |volume=306 |issue= 2|pages= 525–30 |year= 1995 |pmid= 7887906 |doi= 10.1042/bj3060525| pmc=1136549 }}
*{{cite journal  | author=Lavu S, Clark J, Swarup R, ''et al.'' |title=Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 2 |pages= 811-5 |year= 1988 |pmid= 3124840 |doi=  }}
*{{cite journal  |vauthors=Wu HC, Lin CT |title=Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis. |journal=Lab. Invest. |volume=71 |issue= 2 |pages= 175–81 |year= 1994 |pmid= 8078296 |doi=  }}
*{{cite journal  | author=Zumbihl R, Breuiller-Fouché M, Carrette J, ''et al.'' |title=Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. |journal=Eur. J. Pharmacol. |volume=288 |issue= 1 |pages= 9-15 |year= 1995 |pmid= 7705473 |doi=  }}
*{{cite journal  |vauthors=Nitta K, Uchida K, Kawashima A |title=Identification of GTP-binding proteins in human glomeruli. |journal=Nippon Jinzo Gakkai shi |volume=36 |issue= 1 |pages= 9–12 |year= 1994 |pmid= 8107314 |doi=  |display-authors=etal}}
*{{cite journal  | author=Grassie MA, Milligan G |title=Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. |journal=Biochem. J. |volume=306 ( Pt 2) |issue= |pages= 525-30 |year= 1995 |pmid= 7887906 |doi=  }}
*{{cite journal  |vauthors=Georgoussi Z, Carr C, Milligan G |title=Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 62–9 |year= 1993 |pmid= 8393523 |doi=  }}
*{{cite journal  | author=Wu HC, Lin CT |title=Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis. |journal=Lab. Invest. |volume=71 |issue= 2 |pages= 175-81 |year= 1994 |pmid= 8078296 |doi=  }}
*{{cite journal  |vauthors=Laugwitz KL, Allgeier A, Offermanns S |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi=10.1073/pnas.93.1.116 | pmc=40189  |display-authors=etal}}
*{{cite journal  | author=Nitta K, Uchida K, Kawashima A, ''et al.'' |title=Identification of GTP-binding proteins in human glomeruli. |journal=Nippon Jinzo Gakkai shi |volume=36 |issue= 1 |pages= 9-12 |year= 1994 |pmid= 8107314 |doi=  }}
*{{cite journal  |vauthors=Kawano N, Ito T, Kitamura H |title=Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms. |journal=Pathol. Int. |volume=46 |issue= 6 |pages= 393–8 |year= 1997 |pmid= 8869990 |doi=10.1111/j.1440-1827.1996.tb03629.x |display-authors=etal}}
*{{cite journal  | author=Georgoussi Z, Carr C, Milligan G |title=Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 62-9 |year= 1993 |pmid= 8393523 |doi=  }}
*{{cite journal  |vauthors=De Vries L, Elenko E, Hubler L |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203–8 |year= 1997 |pmid= 8986788 |doi=10.1073/pnas.93.26.15203 | pmc=26381  |display-authors=etal}}
*{{cite journal  | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116-20 |year= 1996 |pmid= 8552586 |doi=  }}
*{{cite journal  |vauthors=Valenzuela D, Han X, Mende U |title=G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 5 |pages= 1727–32 |year= 1997 |pmid= 9050846 |doi=10.1073/pnas.94.5.1727 | pmc=19984  |display-authors=etal}}
*{{cite journal  | author=Kawano N, Ito T, Kitamura H, ''et al.'' |title=Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms. |journal=Pathol. Int. |volume=46 |issue= 6 |pages= 393-8 |year= 1997 |pmid= 8869990 |doi=  }}
*{{cite journal  |vauthors=Chen C, Zheng B, Han J, Lin SC |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8679–85 |year= 1997 |pmid= 9079700 |doi=10.1074/jbc.272.13.8679 }}
*{{cite journal  | author=De Vries L, Elenko E, Hubler L, ''et al.'' |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203-8 |year= 1997 |pmid= 8986788 |doi=  }}
*{{cite journal  |vauthors=Natochin M, Lipkin VM, Artemyev NO |title=Interaction of human retinal RGS with G-protein alpha-subunits. |journal=FEBS Lett. |volume=411 |issue= 2–3 |pages= 179–82 |year= 1997 |pmid= 9271201 |doi=10.1016/S0014-5793(97)00687-X  }}
*{{cite journal  | author=Valenzuela D, Han X, Mende U, ''et al.'' |title=G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 5 |pages= 1727-32 |year= 1997 |pmid= 9050846 |doi=  }}
*{{cite journal  |vauthors=Busconi L, Denker BM |title=Analysis of the N-terminal binding domain of Go alpha. |journal=Biochem. J. |volume=328 |issue= 1|pages= 23–31 |year= 1998 |pmid= 9359829 |doi=  | pmc=1218882 }}
*{{cite journal  | author=Chen C, Zheng B, Han J, Lin SC |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8679-85 |year= 1997 |pmid= 9079700 |doi= }}
*{{cite journal  | author=Natochin M, Lipkin VM, Artemyev NO |title=Interaction of human retinal RGS with G-protein alpha-subunits. |journal=FEBS Lett. |volume=411 |issue= 2-3 |pages= 179-82 |year= 1997 |pmid= 9271201 |doi=  }}
*{{cite journal  | author=Busconi L, Denker BM |title=Analysis of the N-terminal binding domain of Go alpha. |journal=Biochem. J. |volume=328 ( Pt 1) |issue=  |pages= 23-31 |year= 1998 |pmid= 9359829 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Intracellular signaling peptides and proteins}}
{{WikiDoc Sources}}
 
 
{{gene-16-stub}}

Latest revision as of 08:50, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.[1][2][3]

Mutations in this gene have been shown to cause epileptic encephalopathy.[4]

Interactions

GNAO1 has been shown to interact with:

References

  1. ↑ Murtagh JJ Jr; Eddy R; Shows TB; Moss J; Vaughan M (Mar 1991). "Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16". Mol Cell Biol. 11 (2): 1146–55. PMC 359797. PMID 1899283.
  2. ↑ Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (Jul 2001). "Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels". J Biol Chem. 276 (31): 28731–8. doi:10.1074/jbc.M104806200. PMID 11395521.
  3. ↑ "Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O".
  4. ↑ Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H (September 2013). "De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy". Am. J. Hum. Genet. 93 (3): 496–505. doi:10.1016/j.ajhg.2013.07.014. PMC 3769919. PMID 23993195.
  5. ↑ Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  6. ↑ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID 11253162.
  7. ↑ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  8. ↑ Woulfe DS, Stadel JM (1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
  9. ↑ Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. PMC 3107604. PMID 18407463.
  10. ↑ Tall GG, Krumins AM, Gilman AG (2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.

Further reading


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