RAB4A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein Rab-4A''' is a [[protein]] that in humans is encoded by the ''RAB4A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB4A RAB4A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5867| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_RAB4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yu9.
| PDB = {{PDB2|1yu9}}, {{PDB2|1z0k}}, {{PDB2|2bmd}}, {{PDB2|2bme}}
| Name = RAB4A, member RAS oncogene family
| HGNCid = 9781
| Symbol = RAB4A
| AltSymbols =; RAB4
| OMIM = 179511
| ECnumber = 
| Homologene = 55834
| MGIid = 105069
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5867
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004569
    | Hs_RefseqmRNA = NM_004578
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19341
    | Mm_Ensembl = ENSMUSG00000019478
    | Mm_RefseqmRNA = NM_009003
    | Mm_RefseqProtein = NP_033029
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 126692115
    | Mm_GenLoc_end = 126721377
    | Mm_Uniprot = Q3TSQ6
  }}
}}
'''RAB4A, member RAS oncogene family''', also known as '''RAB4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB4A RAB4A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5867| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RAB4A has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[CD2AP]],<ref name = pmid12559036>{{cite journal | vauthors = Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y | title = CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl | journal = Traffic | volume = 4 | issue = 2 | pages = 97–112 | date = Feb 2003 | pmid = 12559036 | doi =  10.1034/j.1600-0854.2003.40205.x}}</ref>
| section_title =  
* [[KIF3B]],<ref name = pmid12832475>{{cite journal | vauthors = Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM | title = Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4892–900 | date = Jul 2003 | pmid = 12832475 | pmc = 162221 | doi = 10.1128/mcb.23.14.4892-4900.2003}}</ref>
| summary_text =  
* [[RAB11FIP1]],<ref name = pmid11786538>{{cite journal | vauthors = Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW | title = Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 14 | pages = 12190–9 | date = Apr 2002 | pmid = 11786538 | doi = 10.1074/jbc.M108665200 }}</ref>  
}}
* [[RABEP1]],<ref name = pmid9524117>{{cite journal | vauthors = Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M | title = Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 | journal = The EMBO Journal | volume = 17 | issue = 7 | pages = 1941–51 | date = Apr 1998 | pmid = 9524117 | pmc = 1170540 | doi = 10.1093/emboj/17.7.1941 }}</ref>  and
* [[STX4]].<ref name = pmid11063739>{{cite journal | vauthors = Li L, Omata W, Kojima I, Shibata H | title = Direct interaction of Rab4 with syntaxin 4 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5265–73 | date = Feb 2001 | pmid = 11063739 | doi = 10.1074/jbc.M003883200 }}</ref>


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Stibbs HH, Seed JR |title=Short-term metabolism of (14-C) tryptophan in rats infected with Trypanosoma brucei gambiense. |journal=J. Infect. Dis. |volume=131 |issue= 4 |pages= 459-62 |year= 1975 |pmid= 1117200 |doi=  }}
*{{cite journal  | author=van der Sluijs P, Hull M, Huber LA, ''et al.'' |title=Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle. |journal=EMBO J. |volume=11 |issue= 12 |pages= 4379-89 |year= 1992 |pmid= 1425574 |doi=  }}
*{{cite journal  | author=Bailly E, McCaffrey M, Touchot N, ''et al.'' |title=Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. |journal=Nature |volume=350 |issue= 6320 |pages= 715-8 |year= 1991 |pmid= 1902553 |doi= 10.1038/350715a0 }}
*{{cite journal  | author=Rousseau-Merck MF, Zahraoui A, Touchot N, ''et al.'' |title=Chromosome assignment of four RAS-related RAB genes. |journal=Hum. Genet. |volume=86 |issue= 4 |pages= 350-4 |year= 1991 |pmid= 1999336 |doi=  }}
*{{cite journal  | author=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394-401 |year= 1989 |pmid= 2501306 |doi=  }}
*{{cite journal  | author=Cormont M, Tanti JF, Zahraoui A, ''et al.'' |title=Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1. |journal=Eur. J. Biochem. |volume=219 |issue= 3 |pages= 1081-5 |year= 1994 |pmid= 8112321 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Karniguian A, Zahraoui A, Tavitian A |title=Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7647-51 |year= 1993 |pmid= 8356066 |doi=  }}
*{{cite journal  | author=Valentijn JA, LaCivita DQ, Gumkowski FD, Jamieson JD |title=Rab4 associates with the actin terminal web in developing rat pancreatic acinar cells. |journal=Eur. J. Cell Biol. |volume=72 |issue= 1 |pages= 1-8 |year= 1997 |pmid= 9013719 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Vitale G, Rybin V, Christoforidis S, ''et al.'' |title=Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5. |journal=EMBO J. |volume=17 |issue= 7 |pages= 1941-51 |year= 1998 |pmid= 9524117 |doi= 10.1093/emboj/17.7.1941 }}
*{{cite journal  | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
*{{cite journal  | author=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711-21 |year= 1999 |pmid= 10512627 |doi=  }}
*{{cite journal  | author=Nagelkerken B, Van Anken E, Van Raak M, ''et al.'' |title=Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles. |journal=Biochem. J. |volume=346 Pt 3 |issue=  |pages= 593-601 |year= 2000 |pmid= 10698684 |doi=  }}
*{{cite journal  | author=Gerez L, Mohrmann K, van Raak M, ''et al.'' |title=Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis. |journal=Mol. Biol. Cell |volume=11 |issue= 7 |pages= 2201-11 |year= 2000 |pmid= 10888662 |doi=  }}
*{{cite journal  | author=Li L, Omata W, Kojima I, Shibata H |title=Direct interaction of Rab4 with syntaxin 4. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5265-73 |year= 2001 |pmid= 11063739 |doi= 10.1074/jbc.M003883200 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Cormont M, Mari M, Galmiche A, ''et al.'' |title=A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1637-42 |year= 2001 |pmid= 11172003 |doi= 10.1073/pnas.031586998 }}
*{{cite journal  | author=Bielli A, Thörnqvist PO, Hendrick AG, ''et al.'' |title=The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1141-53 |year= 2001 |pmid= 11243854 |doi= 10.1006/bbrc.2001.4468 }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Stibbs HH, Seed JR | title = Short-term metabolism of (14-C) tryptophan in rats infected with Trypanosoma brucei gambiense | journal = The Journal of Infectious Diseases | volume = 131 | issue = 4 | pages = 459–62 | date = Apr 1975 | pmid = 1117200 | doi = 10.1093/infdis/131.4.459 }}
* {{cite journal | vauthors = van der Sluijs P, Hull M, Huber LA, Mâle P, Goud B, Mellman I | title = Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle | journal = The EMBO Journal | volume = 11 | issue = 12 | pages = 4379–89 | date = Dec 1992 | pmid = 1425574 | pmc = 557012 | doi =  }}
* {{cite journal | vauthors = Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M | title = Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2 | journal = Nature | volume = 350 | issue = 6320 | pages = 715–8 | date = Apr 1991 | pmid = 1902553 | doi = 10.1038/350715a0 }}
* {{cite journal | vauthors = Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R | title = Chromosome assignment of four RAS-related RAB genes | journal = Human Genetics | volume = 86 | issue = 4 | pages = 350–4 | date = Feb 1991 | pmid = 1999336 | doi = 10.1007/BF00201831 }}
* {{cite journal | vauthors = Zahraoui A, Touchot N, Chardin P, Tavitian A | title = The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion | journal = The Journal of Biological Chemistry | volume = 264 | issue = 21 | pages = 12394–401 | date = Jul 1989 | pmid = 2501306 | doi =  }}
* {{cite journal | vauthors = Cormont M, Tanti JF, Zahraoui A, Van Obberghen E, Le Marchand-Brustel Y | title = Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1 | journal = European Journal of Biochemistry / FEBS | volume = 219 | issue = 3 | pages = 1081–5 | date = Feb 1994 | pmid = 8112321 | doi = 10.1111/j.1432-1033.1994.tb18591.x }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Karniguian A, Zahraoui A, Tavitian A | title = Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 16 | pages = 7647–51 | date = Aug 1993 | pmid = 8356066 | pmc = 47199 | doi = 10.1073/pnas.90.16.7647 }}
* {{cite journal | vauthors = Valentijn JA, LaCivita DQ, Gumkowski FD, Jamieson JD | title = Rab4 associates with the actin terminal web in developing rat pancreatic acinar cells | journal = European Journal of Cell Biology | volume = 72 | issue = 1 | pages = 1–8 | date = Jan 1997 | pmid = 9013719 | doi =  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M | title = Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 | journal = The EMBO Journal | volume = 17 | issue = 7 | pages = 1941–51 | date = Apr 1998 | pmid = 9524117 | pmc = 1170540 | doi = 10.1093/emboj/17.7.1941 }}
* {{cite journal | vauthors = Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB | title = Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 3 | pages = 657–62 | date = May 1999 | pmid = 10329441 | doi = 10.1006/bbrc.1999.0651 }}
* {{cite journal | vauthors = Shisheva A, Chinni SR, DeMarco C | title = General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications | journal = Biochemistry | volume = 38 | issue = 36 | pages = 11711–21 | date = Sep 1999 | pmid = 10512627 | doi = 10.1021/bi990200r }}
* {{cite journal | vauthors = Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P | title = Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles | journal = The Biochemical Journal | volume = 346 Pt 3 | issue = 3 | pages = 593–601 | date = Mar 2000 | pmid = 10698684 | pmc = 1220890 | doi = 10.1042/0264-6021:3460593 }}
* {{cite journal | vauthors = Gerez L, Mohrmann K, van Raak M, Jongeneelen M, Zhou XZ, Lu KP, van Der Sluijs P | title = Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis | journal = Molecular Biology of the Cell | volume = 11 | issue = 7 | pages = 2201–11 | date = Jul 2000 | pmid = 10888662 | pmc = 14913 | doi = 10.1091/mbc.11.7.2201 }}
* {{cite journal | vauthors = Li L, Omata W, Kojima I, Shibata H | title = Direct interaction of Rab4 with syntaxin 4 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5265–73 | date = Feb 2001 | pmid = 11063739 | doi = 10.1074/jbc.M003883200 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y | title = A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 4 | pages = 1637–42 | date = Feb 2001 | pmid = 11172003 | pmc = 29309 | doi = 10.1073/pnas.031586998 }}
* {{cite journal | vauthors = Bielli A, Thörnqvist PO, Hendrick AG, Finn R, Fitzgerald K, McCaffrey MW | title = The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1 | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 5 | pages = 1141–53 | date = Mar 2001 | pmid = 11243854 | doi = 10.1006/bbrc.2001.4468 }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
{{Refend}}
 
{{PDB Gallery|geneid=5867}}
 
{{Protein-stub}}

Latest revision as of 08:47, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.[1]

Interactions

RAB4A has been shown to interact with:

References

  1. ↑ "Entrez Gene: RAB4A RAB4A, member RAS oncogene family".
  2. ↑ Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic. 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
  3. ↑ Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (Jul 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Molecular and Cellular Biology. 23 (14): 4892–900. doi:10.1128/mcb.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
  4. ↑ Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
  5. ↑ Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117.
  6. ↑ Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=RAB4A&oldid=1410907"