Endothelin converting enzyme 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Endothelin converting enzyme 1''', also known as '''ECE1''', is an [[enzyme]] which in humans is encoded by the ''ECE1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref><ref name="pmid7805846">{{cite journal | vauthors = Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H | title = Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) | journal = FEBS Lett. | volume = 356 | issue = 2–3 | pages = 238–43 |date=December 1994 | pmid = 7805846 | doi = 10.1016/0014-5793(94)01277-6| url = http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01277-6 }}</ref><ref name="pmid7864876">{{cite journal | vauthors = Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K | title = Cloning and functional expression of human endothelin-converting enzyme cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 207 | issue = 2 | pages = 807–12 |date=February 1995 | pmid = 7864876 | doi = 10.1006/bbrc.1995.1258 | url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin converting enzyme 1
| HGNCid = 3146
| Symbol = ECE1
| AltSymbols =; ECE
| OMIM = 600423
| ECnumber = 
| Homologene = 1068
| MGIid = 1101357
| GeneAtlas_image1 = PBB_GE_ECE1_201750_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ECE1_201749_at_tn.png
| Function = {{GNF_GO|id=GO:0004245 |text = neprilysin activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016512 |text = endothelin-converting enzyme 1 activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1889
    | Hs_Ensembl = ENSG00000117298
    | Hs_RefseqProtein = NP_001388
    | Hs_RefseqmRNA = NM_001397
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 21417664
    | Hs_GenLoc_end = 21544584
    | Hs_Uniprot = P42892
    | Mm_EntrezGene = 230857
    | Mm_Ensembl = ENSMUSG00000057530
    | Mm_RefseqmRNA = XM_989734
    | Mm_RefseqProtein = XP_994828
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 137134373
    | Mm_GenLoc_end = 137237305
    | Mm_Uniprot = Q3TUZ3
  }}
}}
'''Endothelin converting enzyme 1''', also known as '''ECE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 ([[endothelin 1|EDN1]]), -2 ([[endothelin 2|EDN2]]), and -3 ([[endothelin 3|EDN3]]) to biologically active peptides.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yorimitsu K, Moroi K, Inagaki N, ''et al.'' |title=Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 721-7 |year= 1995 |pmid= 7695628 |doi=  }}
*{{cite journal  | vauthors=Yorimitsu K, Moroi K, Inagaki N |title=Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2 |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 721–7 |year= 1995 |pmid= 7695628 |doi=10.1006/bbrc.1995.1397 |display-authors=etal}}
*{{cite journal  | author=Schmidt M, Kröger B, Jacob E, ''et al.'' |title=Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). |journal=FEBS Lett. |volume=356 |issue= 2-3 |pages= 238-43 |year= 1995 |pmid= 7805846 |doi=  }}
*{{cite journal  | vauthors=Schmidt M, Kröger B, Jacob E |title=Molecular characterization of human and bovine endothelin converting enzyme (ECE-1) |journal=FEBS Lett. |volume=356 |issue= 2–3 |pages= 238–43 |year= 1995 |pmid= 7805846 |doi=10.1016/0014-5793(94)01277-6 |display-authors=etal}}
*{{cite journal  | author=Shimada K, Matsushita Y, Wakabayashi K, ''et al.'' |title=Cloning and functional expression of human endothelin-converting enzyme cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=207 |issue= 2 |pages= 807-12 |year= 1995 |pmid= 7864876 |doi= 10.1006/bbrc.1995.1258 }}
*{{cite journal  | vauthors=Shimada K, Matsushita Y, Wakabayashi K |title=Cloning and functional expression of human endothelin-converting enzyme cDNA |journal=Biochem. Biophys. Res. Commun. |volume=207 |issue= 2 |pages= 807–12 |year= 1995 |pmid= 7864876 |doi= 10.1006/bbrc.1995.1258 |display-authors=etal}}
*{{cite journal  | author=Valdenaire O, Rohrbacher E, Mattei MG |title=Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29794-8 |year= 1996 |pmid= 8530372 |doi=  }}
*{{cite journal  | vauthors=Valdenaire O, Rohrbacher E, Mattei MG |title=Organization of the gene encoding the human endothelin-converting enzyme (ECE-1) |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29794–8 |year= 1996 |pmid= 8530372 |doi=10.1074/jbc.270.50.29794 }}
*{{cite journal  | author=Matsuoka R, Sawamura T, Yamada K, ''et al.'' |title=Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 4 |pages= 322-4 |year= 1996 |pmid= 8641140 |doi=  }}
*{{cite journal  | vauthors=Matsuoka R, Sawamura T, Yamada K |title=Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1 |journal=Cytogenet. Cell Genet. |volume=72 |issue= 4 |pages= 322–4 |year= 1996 |pmid= 8641140 |doi=10.1159/000134214 |display-authors=etal}}
*{{cite journal  | author=Orzechowski HD, Richter CM, Funke-Kaiser H, ''et al.'' |title=Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells. |journal=J. Mol. Med. |volume=75 |issue= 7 |pages= 512-21 |year= 1997 |pmid= 9253714 |doi=  }}
*{{cite journal  | vauthors=Orzechowski HD, Richter CM, Funke-Kaiser H |title=Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells |journal=J. Mol. Med. |volume=75 |issue= 7 |pages= 512–21 |year= 1997 |pmid= 9253714 |doi=10.1007/s001090050136 |display-authors=etal}}
*{{cite journal  | author=Schweizer A, Valdenaire O, Nelböck P, ''et al.'' |title=Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. |journal=Biochem. J. |volume=328 ( Pt 3) |issue=  |pages= 871-7 |year= 1998 |pmid= 9396733 |doi=  }}
*{{cite journal  | vauthors=Schweizer A, Valdenaire O, Nelböck P |title=Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations |journal=Biochem. J. |volume=328 ( Pt 3) |issue=  Pt 3|pages= 871–7 |year= 1998 |pmid= 9396733 |doi=  | pmc=1218999  |display-authors=etal}}
*{{cite journal  | author=Kido T, Sawamura T, Masaki T |title=The processing pathway of endothelin-1 production. |journal=J. Cardiovasc. Pharmacol. |volume=31 Suppl 1 |issue=  |pages= S13-5 |year= 1998 |pmid= 9595387 |doi=  }}
*{{cite journal  | vauthors=Kido T, Sawamura T, Masaki T |title=The processing pathway of endothelin-1 production |journal=J. Cardiovasc. Pharmacol. |volume=31 Suppl 1 |issue=  |pages= S13–5 |year= 1998 |pmid= 9595387 |doi=10.1097/00005344-199800001-00006 }}
*{{cite journal  | author=Hofstra RM, Valdenaire O, Arch E, ''et al.'' |title=A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 304-8 |year= 1999 |pmid= 9915973 |doi=  }}
*{{cite journal  | vauthors=Hofstra RM, Valdenaire O, Arch E |title=A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 304–8 |year= 1999 |pmid= 9915973 |doi=10.1086/302184 | pmc=1377732  |display-authors=etal}}
*{{cite journal  | author=Lee S, Lin M, Mele A, ''et al.'' |title=Proteolytic processing of big endothelin-3 by the kell blood group protein. |journal=Blood |volume=94 |issue= 4 |pages= 1440-50 |year= 1999 |pmid= 10438732 |doi=  }}
*{{cite journal  | vauthors=Lee S, Lin M, Mele A |title=Proteolytic processing of big endothelin-3 by the kell blood group protein |journal=Blood |volume=94 |issue= 4 |pages= 1440–50 |year= 1999 |pmid= 10438732 |doi=  |display-authors=etal}}
*{{cite journal  | author=Valdenaire O, Lepailleur-Enouf D, Egidy G, ''et al.'' |title=A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization. |journal=Eur. J. Biochem. |volume=264 |issue= 2 |pages= 341-9 |year= 1999 |pmid= 10491078 |doi=  }}
*{{cite journal  | vauthors=Valdenaire O, Lepailleur-Enouf D, Egidy G |title=A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization |journal=Eur. J. Biochem. |volume=264 |issue= 2 |pages= 341–9 |year= 1999 |pmid= 10491078 |doi=10.1046/j.1432-1327.1999.00602.x |display-authors=etal}}
*{{cite journal  | author=Fahnoe DC, Johnson GD, Herman SB, Ahn K |title=Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells. |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 385-93 |year= 2000 |pmid= 10620363 |doi= 10.1006/abbi.1999.1586 }}
*{{cite journal  | vauthors=Fahnoe DC, Johnson GD, Herman SB, Ahn K |title=Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 385–93 |year= 2000 |pmid= 10620363 |doi= 10.1006/abbi.1999.1586 }}
*{{cite journal  | author=López-Ongil S, Senchak V, Saura M, ''et al.'' |title=Superoxide regulation of endothelin-converting enzyme. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26423-7 |year= 2000 |pmid= 10833511 |doi= 10.1074/jbc.M000767200 }}
*{{cite journal  | vauthors=López-Ongil S, Senchak V, Saura M |title=Superoxide regulation of endothelin-converting enzyme |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26423–7 |year= 2000 |pmid= 10833511 |doi= 10.1074/jbc.M000767200 |display-authors=etal}}
*{{cite journal  | author=Hachiya A, Kobayashi T, Takema Y, Imokawa G |title=Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5395-403 |year= 2002 |pmid= 11723113 |doi= 10.1074/jbc.M105874200 }}
*{{cite journal  | vauthors=Hachiya A, Kobayashi T, Takema Y, Imokawa G |title=Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5395–403 |year= 2002 |pmid= 11723113 |doi= 10.1074/jbc.M105874200 }}
*{{cite journal  | author=Inguimbert N, Coric P, Poras H, ''et al.'' |title=Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP). |journal=J. Med. Chem. |volume=45 |issue= 7 |pages= 1477-86 |year= 2002 |pmid= 11906289 |doi=  }}
*{{cite journal  | vauthors=Inguimbert N, Coric P, Poras H |title=Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP) |journal=J. Med. Chem. |volume=45 |issue= 7 |pages= 1477–86 |year= 2002 |pmid= 11906289 |doi=10.1021/jm0005454 |display-authors=etal}}
*{{cite journal  | author=MacLeod KJ, Husain RD, Gage DA, Ahn K |title=Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46355-63 |year= 2003 |pmid= 12244060 |doi= 10.1074/jbc.M207972200 }}
*{{cite journal  | vauthors=MacLeod KJ, Husain RD, Gage DA, Ahn K |title=Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46355–63 |year= 2003 |pmid= 12244060 |doi= 10.1074/jbc.M207972200 }}
*{{cite journal  | author=Muller L, Barret A, Etienne E, ''et al.'' |title=Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 545-55 |year= 2003 |pmid= 12393864 |doi= 10.1074/jbc.M208949200 }}
*{{cite journal  | vauthors=Muller L, Barret A, Etienne E |title=Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 545–55 |year= 2003 |pmid= 12393864 |doi= 10.1074/jbc.M208949200 |display-authors=etal}}
*{{cite journal  | author=Eckman EA, Watson M, Marlow L, ''et al.'' |title=Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2081-4 |year= 2003 |pmid= 12464614 |doi= 10.1074/jbc.C200642200 }}
*{{cite journal  | vauthors=Eckman EA, Watson M, Marlow L |title=Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2081–4 |year= 2003 |pmid= 12464614 |doi= 10.1074/jbc.C200642200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Masatsugu K, Itoh H, Chun TH, ''et al.'' |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress. |journal=Regul. Pept. |volume=111 |issue= 1-3 |pages= 13-9 |year= 2003 |pmid= 12609744 |doi=  }}
*{{cite journal  | vauthors=Masatsugu K, Itoh H, Chun TH |title=Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress |journal=Regul. Pept. |volume=111 |issue= 1–3 |pages= 13–9 |year= 2003 |pmid= 12609744 |doi=10.1016/S0167-0115(02)00219-7 |display-authors=etal}}
*{{cite journal  | vauthors=Smollich M, Götte M, Yip GW |title=On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer |journal=Breast Cancer Res. Treat. |volume=106 |issue= 3 |pages= 361–9 |year= 2007 |pmid= 17295044 |doi=  10.1007/s10549-007-9516-9 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:40, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.[1][2][3]

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ECE1 endothelin converting enzyme 1".
  2. ↑ Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.
  3. ↑ Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876.

Further reading



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