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{{CMG}} {{AE}} {{AKI}}


{{Roseola}}
{{CMG}}:{{AE}}{{DAMI}}


==Overview==


==Historical Perspective==
==[[Roseola overview|Overview]]==
*In 1947, the first case of congenital varicella syndrome was reported.


==Pathophysiology==
==[[Roseola historical perspective|Historical Perspective]]==


===Pathogenesis===
==[[Roseola classification|Classification]]==
*Once a pregnant women has a primary varicella infection, transplacental transmission of the virus can take place affecting the fetus in utero.
*The risk of abortion is high when the infection in the fetus occurs before 20 weeks of gestation.


===Genetics===
==[[Roseola pathophysiology|Pathophysiology]]==
===Gross Pathology===


===Microscopic Pathology===
==[[Roseola causes|Causes]]==


==Epidemiology and Demographics==
==[[Roseola differential diagnosis|Differentiating Any Disease from other Diseases]]==


==Natural History, Prognosis and Complications==
==[[Roseola epidemiology and demographics|Epidemiology and Demographics]]==
===Prognosis===
Prognosis of infants with congenital varicella syndrome is poor, early death is due to gastroesophageal reflux and recurrent aspiration pneumonia and respiratory failure.
===Complications===
*Fetal demise
*Intrauterine growth restriction
*Hydrops
*Limb deformities
*Microcephaly


==Diagnosis==
==[[Roseola risk factors|Risk Factors]]==  


===History and Symptoms===
==[[Roseola screening|Screening]]==  


===Physical Examination===
==[[Roseola natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
Clinical manifestations suggestive of Congenital varicella syndrome include:


{| border="1"
==Diagnosis==
|-
[[Roseola history and symptoms|History and Symptoms]] | [[Roseola physical examination|Physical Examination]] | [[Roseola laboratory findings|Laboratory Findings]] | [[Roseola electrocardiogram|Electrocardiogram]] | [[Roseola chest x ray|Chest X Ray]] | [[Roseola CT|CT]] | [[Roseola MRI|MRI]] | [[Roseola echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Roseola other imaging findings|Other Imaging Findings]] | [[Roseola other diagnostic studies|Other Diagnostic Studies]]
!
!'''Clinical Manifestations in congenital varicella syndrome'''
|-
!'''Skin'''
|
*Cicatricial lesions
*Cutaneous defects
*Hypopigmentation                                                                                                               
|-
!'''Eye'''
|
*Chorioretinitis
*Cataracts
*Micropthalmia
*Anisocoria
|-
!'''Central Nervous System'''
|  
*Intrauterine encephalitis
*Cortical atrophy/porencephaly
*Seizures
*Mental retardation
*Autonomic instability
|-
!'''Musculoskeletal system'''
|  
*Limb hypoplasia
*Muscle hypoplasia
|-
!'''Gastrointestinal'''
|
*Gastrointestinal reflux
|-
!'''Systemic Manifestations'''
|
*Intrauterine growth retardation
*Developmental delay
|-
!'''Urinary Tract'''
|
*Hydroureter
*Hydronephrosis
|}
 
===Laboratory Findings===
 
===Imaging Studies===


==Treatment==
==Treatment==
[[Roseola medical therapy|Medical Therapy]] | [[Roseola surgery|Surgery]] | [[Roseola primary prevention|Primary Prevention]] | [[Roseola secondary prevention|Secondary Prevention]] | [[Roseola cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Roseola future or investigational therapies|Future or Investigational Therapies]]


===Medical Therapy===
==Case Studies==
 
[[Roseola case study one|Case #1]]
===Surgical Therapy===
 
==Prevention==
 
===Primary Prevention===
*In pregnant women with exposure to varicella, passive immunization with varicella zoster virus antibodies (VZV IgG) should be administered after 72-96hours of exposure. Passive immnuniaztion with immmunoglobulins decreases the risk of severe disease in the mother, but its efficacy in preventing the disease to the fetus is not established.
 
===Secondary Prevention===
 
==References==
{{reflist|2}}

Latest revision as of 19:04, 22 May 2017


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Overview

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Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]:Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]


Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Any Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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