View source for Ristocetin induced platelet agglutination

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The '''ristocetin induced platelet aggregation''' (RIPA) is an in vitro assay for [[von Willebrand factor]] activity used to diagnose [[von Willebrand disease]]. It has the benefit over the ristocetin cofactor activity in that it can diagnose type 2B vWD and [[Bernard-Soulier syndrome]].

In an unknown fashion, the antibiotic [[ristocetin]] causes von Willebrand factor to bind the platelet receptor [[glycoprotein Ib]] (GpIb), so when ristocetin is added to normal blood, it causes agglutination. In von Willebrand disease, where von Willebrand factor is absent or defective, abnormal agglutination occurs:

* In type 1 vWD: no agglutination occurs
* In type 2A vWD: no agglutination occurs
* In type 2B vWD: hyperactive agglutination occurs
* In type 2N vWD: normal agglutination occurs
* In type 3 vWD: no agglutination occurs



[[Category:Blood tests]]

[[pl:Aglutynacja płytek indukowana ristocetyną]]


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