Xist

WikiDoc Resources for Xist
Articles
Most recent articles on Xist Most cited articles on Xist Review articles on Xist Articles on Xist in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Xist Images of Xist Photos of Xist Podcasts & MP3s on Xist Videos on Xist
Evidence Based Medicine
Cochrane Collaboration on Xist Bandolier on Xist TRIP on Xist
Clinical Trials
Ongoing Trials on Xist at Clinical Trials.gov Trial results on Xist Clinical Trials on Xist at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Xist NICE Guidance on Xist NHS PRODIGY Guidance FDA on Xist CDC on Xist
Books
Books on Xist
News
Xist in the news Be alerted to news on Xist News trends on Xist
Commentary
Blogs on Xist
Definitions
Definitions of Xist
Patient Resources / Community
Patient resources on Xist Discussion groups on Xist Patient Handouts on Xist Directions to Hospitals Treating Xist Risk calculators and risk factors for Xist
Healthcare Provider Resources
Symptoms of Xist Causes & Risk Factors for Xist Diagnostic studies for Xist Treatment of Xist
Continuing Medical Education (CME)
CME Programs on Xist
International
Xist en Espanol Xist en Francais
Business
Xist in the Marketplace Patents on Xist
Experimental / Informatics
List of terms related to Xist

Overview

Xist is an RNA gene on the X chromosome of the placental mammals that acts as major effector of the X inactivation process.

The Xist RNA, a large (18 kb) transcript, is expressed on the inactive chromosome and not on the active one. It is processed similarly to mRNAs, through splicing and polyadenylation, however, it remains untranslated. It has been suggested that this RNA gene evolved at least partly from a protein coding gene that became a pseudogene.

The inactive X is coated with this transcript, which is essential for the inactivation. X lacking Xist will not be inactivated, while duplication of the Xist gene on another chromosome causes inactivation of that chromosome.

External links

• Xist page of Strauss lab