Wolcott-Rallison syndrome

Wolcott-Rallison syndrome
Classification and external resources
OMIM	226980

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Evidence Based Medicine
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Clinical Trials
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Commentary
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Definitions
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Patient Resources / Community
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Healthcare Provider Resources
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Wolcott-Rallison syndrome abbreviated as WRS is a rare, autosomal recessive disorder with infancy-onset diabetes mellitus, multiple epiphyseal dysplasia, osteopenia, mental retardation or developmental delay, and hepatic and renal dysfunction as main clinical findings. Patients with WRS have mutations in the EIF2AK3 gene, which encodes the pancreatic eukaryotic translation initiation factor 2-alpha kinase 3.