Warburg hypothesis

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Warburg's hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924.[1] He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g. adenosine triphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis). This is in contrast to "healthy" cells which mainly generate energy from oxidative breakdown of pyruvate. Pyruvate is an end-product of glycolysis, and is oxidized within the mitochondria. Hence and according to Warburg, cancer should be interpreted as a mitochondrial dysfunction. Warburg reported a fundamental difference between normal and cancerous cells to be the ratio of glycolysis to respiration; this observation is also known as the Warburg effect.

It is now known that cancer is caused by mutations in the genome of the cells in a process called malignant transformation, resulting in an uncontrolled growth of cells. The metabolic differences observed by Warburg are now thought to be an adaption of cancer cells to the hypoxic (oxygen-deficient) conditions inside solid tumors, and therefore not the cause, as he claimed, but an effect of cancer.

Warburg articulated his hypothesis in a paper entitled The Prime Cause and Prevention of Cancer which he presented in lecture at the meeting of the Nobel-Laureates on June 30, 1966 at Lindau, Lake Constance, Germany. In this speech, Warburg presented evidence in support of the claim that anaerobiosis was a primary cause of cancerous cells. Put in his own words, "the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar."[2]

In recent years, Warburg's hypothesis has re-gained attention due to several discoveries linking impaired mitochondrial function as well as impaired respiration to the growth, division and expansion of tumor cells. In a study by Michael Ristow and co-workers, colon cancer lines were modified to overexpress frataxin. The results of their work suggest that an increase in oxidative metabolism induced by mitochondrion frataxin may inhibit cancer growth in mammals.[3]

Subsequent work has shown that the Warburg effect, indeed, might lead to a promising approach in the treatment of solid tumors. The drug dichloroacetic acid, which promotes respiration and the activity of mitochondria, has been shown to kill cancer cells in vitro and in some animal models.[4] The body often kills damaged cells by apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells where the mitochondria are shut down. According to one hypothesis, the reactivation of mitochondria in cancer cells might also restart their apoptosis program.[5][6]

See also

References

  1. O. Warburg, K. Posener, E. Negelein: Ueber den Stoffwechsel der Tumoren; Biochemische Zeitschrift, Vol. 152, pp. 319-344, 1924. (German). Reprinted in English in the book On metabolism of tumors by O. Warburg, Publisher: Constable, London, 1930.
  2. Otto Heinrich Warburg (June 30, 1966). "The Prime Cause and Prevention of Cancer".
  3. Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, Pfeiffer AF, Ristow M. (January 13, 2006). "Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.". Journal of Biological Chemistry 281 (2): 977 - 981. doi:10.1074/jbc.M511064200. PMID 16263703.
  4. Bonnet S, Archer S, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee C, Lopaschuk G, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter C, Andrade M, Thebaud B, Michelakis E (2007). "A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth". Cancer Cell 11 (1): 37-51. PMID 17222789.
  5. Jerry Adler. "A New Way to Fight Cancer?", Newsweek, 23 Jan 2007. 
  6. Pedersen, Peter L (2007-02). "The cancer cell's "power plants" as promising therapeutic targets: an overview". Journal of bioenergetics and biomembranes 39 (1): 1-12. ISSN 0145479.

Further reading


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