Ventricular septal defect causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Leida Perez, M.D. Associate Editor(s)-In-Chief: Keri Shafer, M.D. [2], Atif Mohammad, M.D., Priyamvada Singh, MBBS

Overview

The causes of VSD are not fully known. The septal defect between the right and left ventricle can be congenital that occurs alone or with other congenital abnormalities. Genetic association suggests the involvement of chromosome band 22q11 microdeletion in the mechanism of VSD development. In adults, Heart attacks can be complicated by the development of VSD.

Causes

  • Genetics - The frequent association between arch abnormalities and significant conal VSDs suggests a common mechanism involving a chromosome band 22q11 microdeletion. Deletions in this area have not been linked with isolated supracristal VSDs.

References

  1. Spicer DE, Hsu HH, Co-Vu J, Anderson RH, Fricker FJ (2014). "Ventricular septal defect". Orphanet J Rare Dis. 9: 144. doi:10.1186/s13023-014-0144-2. PMC 4316658. PMID 25523232.

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