Spinothalamic tract
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| Brain: Spinothalamic tract | ||
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| Spinothalamic tract is 5, in blue at right. | ||
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| Diagram of the principal fasciculi of the spinal cord. (Anterior and posterior spinothalamic fasciculus is labeled at bottom left.) | ||
| Gray's | subject #185 760 | |
| NeuroNames | ancil-114 | |
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Overview
The spinothalamic tract is a sensory pathway originating in the spinal cord that transmits information about pain, temperature, itch and crude touch to the thalamus. The pathway decussates at the level of the spinal cord, rather than in the brainstem like the posterior column-medial lemniscus pathway and corticospinal tract.
The cell bodies of neurons that make up the spinothalamic tract are located principally within the dorsal horn of the spinal cord. These neurons receive input from sensory fibers that innervate the skin and internal organs.
Tracts
There are two main parts of the spinothalamic tract (STT):
- The lateral spinothalamic tract transmits pain and temperature.
- The anterior spinothalamic tract (or ventral spinothalamic tract) transmits touch.
Information transmitted
The types of sensory information transmitted via the spinothalamic tract are described as affective sensation. This means that the sensation is accompanied by a compulsion to act. For instance, an itch is accompanied by a need to scratch, and a painful stimulus makes us want to withdraw from the pain.
Sub-systems
There are two sub-systems identified:
- Direct (for direct conscious appreciation of pain)
- Indirect (for affective and arousal impact of pain). Indirect projections include
- Spino-Reticulo-Thalamo-Cortical (part of the ascending reticular arousal system, aka ARAS)
- Spino-Mesencephalo-Limbic (for affective impact of pain).
Path of sensation
The Spinothalamic Tract, like the Dorsal Column-Medial Lemniscus Tract, use three neurons to convey sensory information from the periphery to conscious level at the cerebral cortex.
Pseudounipolar neurons (those with only one long process) in the dorsal root ganglion have axons that lead from the skin into the dorsal spinal cord where they synapse with secondary neurons in the marginal nucleus. These secondary neurons are called tract cells.
The axons of the tract cells cross over to the other side of the spinal cord via the anterior white commissure, and to the anterolateral corner of the spinal cord (hence the spinothalamic tract being part of the anterolateral system). The axons travel up the length of the spinal cord into the brainstem. Pain travels through spinothalamic tracts, and crosses over in the spinal cord at the point it enters, and then travels up contralaterally.
Traveling up the brainstem, the tract moves dorsally. The neurons ultimately synapse with third-order neurons in several nuclei of the thalamus -- including the medial dorsal, ventral posterior lateral, and ventral medial posterior nuclei. From there, signals go to the cingulate cortex, the primary somatosensory cortex, and insular cortex respectively.
Lesions
Unilateral lesion usually causes contralateral anaesthesia (loss of pain) and temperature. Anaesthesia will normally begin 1-2 segments below the level of lesion, affecting all caudal body areas. This is clinically tested by using pin pricks.
External links
- spinothalamic+tract at eMedicine Dictionary
Brain: rhombencephalon (hindbrain) | |
|---|---|
| Myelencephalon/medulla | anterior/ventral: Arcuate nucleus of medulla • Pyramid (Decussation) • Olivary body • Inferior olivary nucleus • Anterior median fissure • Ventral respiratory group posterior/dorsal: VII,IX,X: Solitary/tract • XII, X: Dorsal • IX,X,XI: Ambiguus • IX: Inferior salivatory nucleus • Gracile nucleus/Cuneate nucleus/Accessory cuneate nucleus • Area postrema • Posterior median sulcus • Dorsal respiratory group raphe/reticular: Sensory decussation • Reticular formation (Gigantocellular nucleus, Parvocellular reticular nucleus, Ventral reticular nucleus, Lateral reticular nucleus, Paramedian reticular nucleus) • Raphe nuclei (Obscurus, Magnus, Pallidus) tracts: Corticospinal tract (Lateral, Anterior) • Inferior cerebellar peduncle • Olivocerebellar tract • Spinocerebellar (Dorsal, Ventral) • Spinothalamic tract • PCML (Posterior external arcuate fibers, Internal arcuate fibers, Medial lemniscus) • Extrapyramidal (Rubrospinal tract, Vestibulospinal tract, Tectospinal tract) |
| Metencephalon/pons | anterior/ventral: Superior olivary nucleus • Basis pontis (Pontine nuclei, Middle cerebellar peduncles) posterior/dorsal: Pontine tegmentum (Trapezoid body, Superior medullary velum, Locus ceruleus, MLF, Vestibulocerebellar tract, V Principal Spinal & Motor, VI, VII, VII: Superior salivary nucleus) • VIII-c (Dorsal, Anterior)/VIII-v (Lateral, Superior, Medial, Inferior) raphe/reticular: Reticular formation (Caudal pontine reticular nucleus, Oral pontine reticular nucleus, Tegmental pontine reticular nucleus, Paramedian pontine reticular formation) • Median raphe nucleus |
| Metencephalon/cerebellum | Vermis • Flocculus • Arbor vitae • Cerebellar tonsil • Inferior medullary velum Molecular layer (Stellate cell, Basket cell, Parallel fiber) • Purkinje cell layer (Purkinje cell) • Granule cell layer (Golgi cell) • Mossy fibers • Climbing fiber |
| Fourth ventricle | apertures (Median, Lateral) • Rhomboid fossa (Vagal trigone, Hypoglossal trigone, Obex, Sulcus limitans, Facial colliculus, Medial eminence) • Lateral recess |
Nervous system, receptors: somatosensory system | |
|---|---|
| Medial lemniscus | Touch/mechanoreceptors: Pacinian corpuscles - vibration • Meissner's corpuscles - light touch • Merkel's discs - pressure • Ruffini endings • Free nerve endings - pain • Hair cells • Baroreceptor Proprioception: Golgi organ - tension/length • Muscle spindle - velocity of change (Intrafusal muscle fiber • Nuclear chain fiber • Nuclear bag fiber) |
| Spinothalamic tract | |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
