Toxic Adenoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Patients with toxic adenomas typically present with signs and symptoms of hyperthyroidism. Common symptoms include fatigue, unintentional weight loss, heat intolerance, diaphoresis, palpitations, anxiety, and nervousness. Specific areas of focus when obtaining a history from the patient of toxic adenoma include the possibility of recent iodide exposure in any form that can provoke transient thyrotoxicosis in a pre-existing toxic nodule such as medication (e.g., amiodarone), radiocontrast dye, dietary supplements.

History

Specific areas of focus when obtaining a history from the patient of toxic adenoma include:[1]

Symptoms

Patients with toxic adenomas typically present with signs and symptoms of thyrotoxicosis. Common symptoms of toxic adenoma include:[1][2][3][4][5][6]

Less common

Rarely patients with a toxic adenoma may experience symptoms due to mass effect of adenoma itself.

Signs of thyrotoxicosis

References

  1. 1.0 1.1 Corvilain B (2003). "The natural history of thyroid autonomy and hot nodules". Ann. Endocrinol. (Paris). 64 (1): 17–22. PMID 12707627.
  2. Carlé A, Andersen SL, Boelaert K, Laurberg P (2017). "MANAGEMENT OF ENDOCRINE DISEASE: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy". Eur. J. Endocrinol. 176 (6): R325–R337. doi:10.1530/EJE-16-0276. PMID 28274949.
  3. Kravets I (2016). "Hyperthyroidism: Diagnosis and Treatment". Am Fam Physician. 93 (5): 363–70. PMID 26926973.
  4. Corrias A, Mussa A (2013). "Thyroid nodules in pediatrics: which ones can be left alone, which ones must be investigated, when and how". J Clin Res Pediatr Endocrinol. 5 Suppl 1: 57–69. doi:10.4274/jcrpe.853. PMC 3608010. PMID 23165002.
  5. Nygaard B (2008). "Hyperthyroidism (primary)". BMJ Clin Evid. 2008. PMC 2907936. PMID 19450325.
  6. Reid JR, Wheeler SF (2005). "Hyperthyroidism: diagnosis and treatment". Am Fam Physician. 72 (4): 623–30. PMID 16127951.
  7. Poppe K, Velkeniers B, Glinoer D (2007). "Thyroid disease and female reproduction". Clin. Endocrinol. (Oxf). 66 (3): 309–21. doi:10.1111/j.1365-2265.2007.02752.x. PMID 17302862.