The WikiDoc Living Textbook of Genetics

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Click Here For A Complete Listing Of All Chapters In The Living Textbook Of Genetics In Alphabetical Order

Genomics topics

Genome project | Paleopolyploidy | Glycomics | Human Genome Project | Proteomics

Chemogenomics | Structural genomics | Pharmacogenetics | Pharmacogenomics | Toxicogenomics | Computational genomics

Bioinformatics | Cheminformatics | Systems biology

Basic Science

v • d • e Genetics: chromosomes
Karyotype - Ploidy - Meiosis Classification: Autosome - Sex chromosome Evolution: Chromosomal inversion - Chromosomal translocation - Polyploidy - Paleopolyploidy Structure: Chromatin (Euchromatin, Heterochromatin) - Nucleosome - Histone (H1, H2A, H2B, H3, H4) - Centromere - Telomere - Chromatid

v • d • e Subfields of genetics
Main subjects	Classical genetics · Conservation genetics · Ecological genetics · Immunogenetics · Molecular genetics · Population genetics · Quantitative genetics
Related topics	Geneticist · Genomics · Medical genetics · Molecular evolution · Reverse genetics

v • d • e Topics in molecular evolution
Natural selection	Background selection • Balancing selection • Directional selection • Disruptive selection • Negative selection • Stabilizing selection • Selective sweep
Models	Models of DNA evolution • Models of nucleotide substitution • Allele frequency • Ka/Ks ratio • Tajima's D
Molecular processes	Gene conversion • Gene duplication • Silent mutation • Synonymous substitution

v • d • e HLA-A serotypes
HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80

v • d • e HLA-B Serotypes and allele groups
HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14]] (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B82 - B83

v • d • e HLA-Cw Serotypes and Allelegroups
HLA-C - Cw1 (Cw11) - Cw2 - Cw3 (Cw9 - Cw10) - Cw4 - Cw5 - Cw6 - Cw7 - Cw8 - Cw12 - Cw13 - Cw14 - Cw15 - Cw16 - Cw17 - Cw*18

Disease States

v • d • e Pathology: chromosome abnormalities (Q90-Q99, 758)
Autosomal trisomies	Down syndrome (21), Edwards syndrome (18), Patau syndrome (13), Trisomy 9, Warkany syndrome 2 (8), Cat eye syndrome (22), Trisomy 22, Trisomy 16
Autosomal monosomies/deletions	Wolf-Hirschhorn syndrome (4), Cri du chat (5), Angelman syndrome/Prader-Willi syndrome (15), Miller-Dieker syndrome/Smith-Magenis syndrome (17), 22q11.2 deletion syndrome (22)
X/Y linked	Monosomy: Turner syndrome (XO) Trisomy: Triple X syndrome (XXX), Klinefelter's syndrome (XXY), XYY, Other Karyotypes: XXXX, XXYY, XXXXX, XXXXY
Translocations	Philadelphia chromosome, Burkitt's lymphoma
Other	Fragile X syndrome, Gonadal dysgenesis (Mixed gonadal dysgenesis)

Pharmacotherapy

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