TRAF is an acronym that refers to a member of the TNF Receptor Associated Factor family of proteins. These proteins are primarily involved in the regulation of inflammation, antiviral responses and apoptosis.
These proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.
Cell signaling: carrier proteins: adaptor proteins
|STAT||STAT1 - STAT2 - STAT3 - STAT4 - STAT5 - STAT6|
|Interferon regulatory factors||IRF1 - IRF2 - IRF3 - IRF6|
|Growth factor receptor-bound protein||GRB2 - GRB7 - GRB10|
|other||14-3-3 (YWHAE, YWHAZ) - Caveolin - Cortactin - Death Inducing Signaling Complex - Paxillin - Myd88 - PIAS - SMAD - SOCS - TRAF|
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